Eye Health Research Articles

Astragaloside IV attenuates ferroptosis and protects against iron overload-induced retinal injury

Retinal injury may be exacerbated by iron overload. Astragaloside IV (AS-IV) has potential applications in the food and healthcare industry to promote eye health. We sought to determine the mechanisms responsible for the protective effects of AS-IV on photoreceptor and retinal pigment epithelium cell death induced by iron overload. We conducted in vitro and in vivo experiments involving AS-IV pretreatment. We tested AS-IV for its ability to protect iron-overload mice from retinal injury. In particular, we analyzed the effects of AS-IV on iron overload-induced ferroptosis in 661W and ARPE-19 cells. AS-IV not only attenuated iron deposition and retinal injury in iron-overload mice but also effectively reduced iron overload-induced ferroptotic cell death in 661W and ARPE-19 cells. AS-IV effectively prevented ferroptosis by inhibiting iron accumulation and lipid peroxidation. In addition, inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2) eliminated the protective effect of AS-IV against ferroptosis. The results suggest that ferroptosis might be a significant cause of retinal cell death associated with iron overload. AS-IV provides protection from iron overload-induced ferroptosis, partly by activating the Nrf2 signaling pathway.

A qualitative study of the ASPECT Patient Engagement Program designed to teach storytelling and advocacy skills to individuals with visual impairments and allies.

This study examined the impact of the ASPECT (Advocacy, Support, Perspective, Empowerment, Communication, and Training) Patient Engagement Program on its alumni in order to understand how they used the storytelling and advocacy skills they learned, determine the strengths of the program, and identify recommendations for strengthening the program. In spring 2023, eight focus groups and one interview were conducted with ASPECT Program alumni. Inductive coding was used to identify themes. Eight themes emerged and included: (a) reasons alumni joined the ASPECT Program, (b) value of combining persons with visual impairments and allies in one cohort, (c) reflections on personal growth, (d) developing and telling one's story, (e) networking with others, (f) advocacy activities, (g) strengths of the ASPECT Program, and (h) recommendations for improving the ASPECT Program. The ASPECT Program provided alumni the opportunity to better understand their own eye health and/or the eye health of others, learn to impactfully tell their story to diverse stakeholders, develop their advocacy skills, and network with others. The use of a training program that includes those with visual impairments and allies is an effective method for providing high-quality training to a diverse group. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Multi-objective optimization of daylighting performance and energy consumption of educational buildings in different climatic zones of China

With the implementation of China's “Healthy Building” and “Dual Carbon” strategies, daylight health and energy-saving carbon reduction in buildings have become key research areas. In educational buildings, early design decisions significantly impact students' eye health and energy consumption reduction, making it crucial to balance these concerns. Studies indicate that sufficient and continuous daylight can significantly improve students' eye health, mood and sleep. To maximize the UDI level at the eye level (seated) and minimize EUI and DGP, this study used the multi-objective optimization tool Wallacei based on NSGA-II (Non-dominated Sorting Genetic Algorithm II) for genetic optimization. This study uses the Shiji Building of Central South University in Changsha, Hunan, as a reference model to provide optimal classroom designs for China's five major thermal design zones: severe cold, cold, hot summer and warm winter, hot summer and cold winter, and mild. The results indicate that optimizing the classroom's deflection angle, length, width, height, and WWR significantly improves energy efficiency and daylighting performance. Specific data shows that an orientation 5° east or 5° west of south helps balance energy consumption and daylighting performance in both large and small classrooms. The length and width of the classrooms vary greatly, but the height generally converges to 3.2 m. Increasing the WWR to 0.5–0.7 demonstrates good energy efficiency and daylighting performance in both large and small classrooms in hot climate zones. In all climate zones, compared to the initial scheme, the Knee solutions reduced the EUI of both types of classrooms by up to 19.0 %, reduced DGP by up to 56.4 %, and increased UDI by up to 19.0 %.

Bacterial, fungal pathogens, and antimicrobial resistance patterns in ocular infections: Insights from a tertiary care hospital, North Karnataka

Background: Ocular infections, including conjunctivitis, keratitis, and endophthalmitis, significantly impact eye health, leading to morbidity, visual impairment, and blindness if not treated. Aims and Objectives: This study focuses on reviewing and analyzing the prevalence of bacterial and fungal pathogens in ocular infections and assessing their antimicrobial susceptibility patterns at Vijayanagar Institute of Medical Sciences, Ballari. Materials and Methods: A cross-sectional study was conducted by collecting ocular infection samples from January 01, 2022, to December 31, 2022. Samples, including corneal scrapings and conjunctival swabs, underwent initial procedures such as Gram staining and were inoculated on various agars. Antimicrobial susceptibility testing was performed using the Kirby–Bauer disk diffusion method. Results: Out of 404 evaluated samples, corneal scrapings were predominant, with a significant incidence of fungal and bacterial growth. Aspergillus spp. and Pseudomonas spp. were the most common fungal and bacterial isolates, respectively. Antimicrobial susceptibility testing revealed that Gram-negative bacilli showed more susceptibility to gentamycin, ceftriaxone, and ciprofloxacin, whereas Gram-positive cocci were more susceptible to tetracycline and doxycycline. Conclusion: The study highlights the cornea as the most common source of ocular infections, with Aspergillus and Pseudomonas spp. being the predominant fungal and bacterial pathogens, respectively. Identifying the prevalent species in this geographical area aids in early diagnosis and treatment, thereby preventing morbidity and improving patient outcomes. The antimicrobial susceptibility pattern observed suggests effective options for treatment, emphasizing the need for ongoing surveillance to adapt to resistance patterns.

Multimodal Eye Imaging, Retina Characteristics, and Psychological Assessment Dataset

The eyes provide insights into psychology, potentially offering a distinctive perspective for psychological health profiles. However, there exist a notable deficiency in datasets that simultaneously encompass eye features and psychological assessments. To address this gap, our study presents a dataset that included Fundus Photography, Psychological Assessment, Retina Characteristics, and Multimodal Imaging (FPRM). FPRM dataset comprise fundus images at different wavelengths (548 nm and 605 nm), image of oxygen saturation for the retina and 8 specific retinal vessels, videos of retinal blood flow and pupillary light reflex, along with 61 items of multimodal quantitative measurement from 384 participants. Additionally, it features psychological assessments across five dimensions (geriatric depression, generalized anxiety disorder, insomnia, activities of daily living, and deterioration), accompanied by fundus photographs and 6 items of retina characteristics from 1683 participants. FPRM dataset is the first to integrate multimodal ophthalmic data and psychological assessments, not only advancing the development of machine learning applications but also facilitating in-depth research into the relationship between eye health and psychological health profiles.

Case Finding and Management of Childhood Cataracts: The Role of a Child Eye Health Programme in Kaduna State, Nigeria

Abstract Objective: To evaluate the output of a child eye health programme in terms of identification, referral, and volume of paediatric cataract surgeries in Kaduna State, Nigeria. Materials and Methods: This was a retrospective review of the North-West Nigeria Child Eye Health Initiative programme referral registers at primary, secondary and tertiary hospitals in Kaduna State. Theatre registers of children 0–16 years who had cataract surgery at National Eye Centre Kaduna between 2016 and 2019 were also reviewed. Information on numbers of children, age, sex, laterality of cataract and programme status were summarised as frequencies, percentages and mean ± standard deviation. The initial 2 years of the programme (2018–2019) were compared with the 2 years (2016–2017) preceding them. Results: Between January 2018 and December 2019; primary health workers screened 41,552 children and referred 2,316 (5.6%). Of those referred 1772 (76.5%) presented at one of three zonal secondary hospitals where nurses identified 492 (27.8%) with leukocoria using torchlights and referred them to the tertiary hospital. At the tertiary hospital, 364 (74.0% of 492) attended and 262 (72.0% of 364) were confirmed to have operable cataracts after dilated slit lamp examination by ophthalmologists. Between 2016 and 2017 (pre-programme years), 201 children had cataract surgery compared to 352 in 2018 and 2019 (programme years) of whom 239 (67.9% of 352) were beneficiaries of the programme. The proportion of girls who had cataract surgery declined from 39.8% to 35.0%, while mean age increased from 5.7 ± 4.2 years to 7.5 ± 4.1 over 4 years. More children with unilateral cataracts (214 [60.8%]) presented during the programme years (Fishers exact test, P = 0.004), whereas unilateral cataract (207 [60.2%]) was significantly more common in males than females (Fisher’s exact P = 0.017). Conclusion: The programme has resulted in improved case detection of childhood leukocoria at primary eye care level. additionally, the eye health referral system in Kaduna State has been strengthened with increasing numbers of children accessing services: majority boys, older children, and unilateral cataracts.

Utilisation of eye health services and compliance with spectacles wear among community school adolescents: a mixed-methods study from Bagmati province of Nepal

ObjectivesThis study aims to determine the factors influencing eye care service utilisation and compliance with spectacles wear among school students.DesignMixed-methods study.Setting27 community schools from 6 districts of Bagmati province of...

Metabolic Deficits in the Retina of a Familial Dysautonomia Mouse Model.

Neurodegenerative retinal diseases such as glaucoma, diabetic retinopathy, Leber's hereditary optic neuropathy (LHON), and dominant optic atrophy (DOA) are marked by progressive death of retinal ganglion cells (RGC). This decline is promoted by structural and functional mitochondrial deficits, including electron transport chain (ETC) impairments, increased oxidative stress, and reduced energy (ATP) production. These cellular mechanisms associated with progressive optic nerve atrophy have been similarly observed in familial dysautonomia (FD) patients, who experience gradual loss of visual acuity due to the degeneration of RGCs, which is thought to be caused by a breakdown of mitochondrial structures, and a disruption in ETC function. Retinal metabolism plays a crucial role in meeting the elevated energetic demands of this tissue, and recent characterizations of FD patients' serum and stool metabolomes have indicated alterations in central metabolic processes and potential systemic deficits of taurine, a small molecule essential for retina and overall eye health. The present study sought to elucidate metabolic alterations that contribute to the progressive degeneration of RGCs observed in FD. Additionally, a critical subpopulation of retinal interneurons, the dopaminergic amacrine cells, mediate the integration and modulation of visual information in a time-dependent manner to RGCs. As these cells have been associated with RGC loss in the neurodegenerative disease Parkinson's, which shares hallmarks with FD, a targeted analysis of the dopaminergic amacrine cells and their product, dopamine, was also undertaken. One dimensional (1D) proton (1H) nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and retinal histology methods were employed to characterize retinae from the retina-specific Elp1 conditional knockout (CKO) FD mouse model (Pax6-Cre; Elp1LoxP/LoxP). Metabolite alterations correlated temporally with progressive RGC degeneration and were associated with reduced mitochondrial function, alterations in ATP production through the Cahill and mini-Krebs cycles, and phospholipid metabolism. Dopaminergic amacrine cell populations were reduced at timepoints P30-P90, and dopamine levels were 25-35% lower in CKO retinae compared to control retinae at P60. Overall, this study has expanded upon our current understanding of retina pathology in FD. This knowledge may apply to other retinal diseases that share hallmark features with FD and may help guide new avenues for novel non-invasive therapeutics to mitigate the progressive optic neuropathy in FD.

A Comparative Study of Eye and Mental Health Based on Physical Activity of Single-Person Households

A Comparative Study of Eye and Mental Health Based on Physical Activity of Single-Person Households

Assessing the cataract surgical rate and gender equity in cataract services in south-east Nigeria

BackgroundIn 2020, almost 100 million people were blind or visually impaired from cataract. Cataract surgery is a cost-effective treatment for cataracts. In Nigeria, twice as many women are cataract blind...

PATHOPHYSIOLOGICAL FACTORS THAT PREDISPOSE PEOPLE TO GLAUCOMA AND MEASURES OF PREVENTION OF GLAUCOMA AMONG THE PATIENTS RECEIVING EYE CARE SERVICES IN THE EYE CLINIC AT JINJA REGIONAL REFERRAL HOSPITAL. A CROSS-SECTIONAL STUDY.

Background Glaucoma is a group of disorders characterized by progressive optic neuropathy resulting in a characteristic appearance of the optic disc and a specific pattern of irreversible visual field defects. The study aims to assess the pathophysiological factors that predispose people to glaucoma and measures of prevention of glaucoma. Methodology A cross-sectional quantitative study was conducted because data was collected at one point in time. A non-probability convenient sampling process was used since a specific group of patients with glaucoma was required among patients above 40 years of age receiving eye health services at JRRH. Results Most of the respondents 78% were above 40 years, 10% were 0 to 19 years with a percentage of 10%, 8.33% were 30 to 39 years and 3.33% were 20 to 29 years. Raised IOP contributed the highest percentage of 58% followed by systemic hypertension with a percentage of 16% then genetics and family history with a percentage of 12% followed medication-related IOP elevation with a percentage of 8% and finally myopia, systemic hypotension, and pseudoexfoliation syndrome all contributing to a percentage of 2% respectively. Early eye checkups turned out to be the most effective means for preventing glaucoma with the highest percentage of 34% followed by drug adherence with a percentage of 28% then reduction on steroid medication with a percentage of 12%. Conclusion Raised IOP and systemic hypertension were the significant factors in glaucoma while early checkups drug adherence and reduction of steroid medications were the significant prevention measures for glaucoma. Recommendation The Ministry of Health should equip all hospitals and health centers with the necessary equipment to enable eye health workers to diagnose glaucoma.

Influencing factors for pediatric eye disorders and health related quality of life: a cross-sectional study in Shanghai, China.

Myopia, strabismus, and ptosis are common pediatric eye diseases, which have a negative impact on children and adolescents in terms of visual function, mental health, and health-related quality of life (HRQoL). Therefore, this study focused on those pediatric eye diseases by analyzing their risk factors and HRQoL for the comprehensive management of myopia, strabismus, and ptosis. A total of 363 participants (2-18 years old) were included in this study for risk factors analysis of myopia, strabismus, and ptosis. We collected demographic characteristics, lifestyle habits and eye care habits of these children and analyzed them by using univariable and multivariable logistic regression. In addition, we applied the Chinese version of Pediatric Quality of Life Inventory-Version 4.0 (PedsQL 4.0) to assess HRQoL in 256 children with strabismus and ptosis. Univariable and multivariable linear regression models were applied to evaluate potential influencing factors of HRQoL. Of all the participants, 140 had myopia, 127 had strabismus, and 145 had ptosis. Based on the multivariable logistic regression analysis model, we found that the history of parental myopia and daily average near-distance eye usage time were risk factors for myopia, and increased body mass index (BMI) was identified as a risk factor for strabismus and ptosis. Individuals with ptosis possessed decreased HRQoL. The multivariable linear regression model suggested that daily average near-distance eye usage time, light intensity during visual tasks, and daily average sleep duration had potential influences on HRQoL. This is the first study to assess the risk factors and HRQoL of myopia, strabismus, and ptosis together. We identified risk factors for these common pediatric eye diseases to help doctors, parents, and teachers better manage them. Our study discovered that children with eye disorders exhibit a notably diminished HRQoL. Consequently, it emphasizes the necessity for increased social attention and mental health assistance for these children.

A detailed survey of the murine limbus, its stem cell distribution, and its boundaries with the cornea and conjunctiva.

The narrow intersection between the cornea and conjunctiva, otherwise known as the limbus, is purported to harbor stem cells (SCs) that replenish the ocular surface epithelium throughout life. Damage to this site or depletion of its SCs can have dire consequences for eye health and vision. To date, various SC and keratin proteins have been used to identify the limbus, however, none could definitively mark its boundaries. Herein, we use the mouse as a model system to investigate whether structural and phenotypic features can be used to define the limbus and its boundaries with adjacent tissues. We demonstrate that differentially aligned blood and lymphatic vessels, intraepithelial nerves, and basal epithelial cellular and nuclei dimensions can be used as structural landmarks of the limbus. Identification of these features enabled approximation of the limbal expanse, which varied across distinct ocular surface quadrants, with the superior nasal and inferior temporal limbus being the widest and narrowest, respectively. Moreover, label-retaining SCs were unevenly distributed across the ocular circumference, with increased numbers in the superior temporal and inferior temporal moieties. These findings will heighten our current understanding of the SC niche, be beneficial for accurately predicting SC distribution to improve their isolation and devising efficacious cell therapies, and importantly, aid the ongoing search for novel SC markers.

A comprehensive review of binocular vision in myopia control

Myopia is a growing problem worldwide and is particularly common among young people. Myopia is a disease that affects the retina responsible for detail in the middle eye and can lead to permanent vision loss. Myopia, a prevalent refractive error causing distant objects to appear blurred, is increasingly affecting global populations, particularly children. By 2050, it's projected that half the world's population will be myopic, largely due to genetic predispositions and environmental factors like excessive near work and limited outdoor activities. A promising approach to managing myopia is binocular vision training, which involves using both eyes to create a single, clear image, potentially slowing myopia progression. Understanding the benefits of this method is critical as we move forward, especially considering the surge in myopia cases during the COVID-19 pandemic due to increased digital device use. Research underscores the importance of addressing lifestyle and promoting outdoor activities and mitigating the impact of near work can help manage myopia progression and associated binocular vision disorders. Binocular vision training shows promise for myopia control by enhancing eye coordination, potentially slowing progression. Key factors include accommodation, AC/A ratios, and phoria, which are essential for effective diagnostics and therapy. Recent research emphasizes a holistic assessment of these elements for precise management of myopia and related binocular vision disorders in children. Understanding the mechanisms and innovative approaches of binocular vision in controlling myopia, highlighting the significance of continuous research and patient education in improving eye health.

Optopreneurship for a competitive and sustainable optometry practice in South Africa

Background: Optopreneurship entails the entrepreneurial activities within the optometry industry. The term is new and derived from optometry and entrepreneurship. Optometrists are professionals who are responsible for screening, examining, diagnosing, treating and managing vision and eye health problems through the provision of optical devices and therapies. Optometry business and entrepreneurship have been poorly studied.Aim: To provide an overview of optopreneurship and optopreneurial activities for competitiveness and sustainability in optometry practice from a South African perspective.Method: Literature was reviewed from Google Scholar, PubMed and ScienceDirect databases using key terms such as entrepreneurship, health entrepreneurship, optometry entrepreneurship and optometry business used.Results: Thirty-four scholarly articles were found to be relevant for the review. Fourteen articles were on entrepreneurship, 13 on eyecare and optometry, 2 on optometry business and 5 on healthcare entrepreneurship. Additionally, 24 websites were reviewed to provide evidence on entrepreneurship and optometry business. Though optometry business has higher revenue turnover potential, conglomerates exhibit superior business acumen over individual practitioners. Optometrists should enhance their business acumen and entrepreneurial agency by identifying underserviced areas such as to stay competitive.Conclusion: Engaging in optopreneurial activities will help optometrists to develop competitive advantage. There is a need to develop and collate optometrists’ business acumen and clinical skills. More research is required in optopreneurship.Contribution: This article seeks to highlight the overview of entrepreneurial activities and opportunities for optometrists in South Africa, and the need to develop a business acumen and entrepreneurial mindset to gain a competitive advantage.

Analysis of human resources governance system in the framework of increasing the business of PT. Rumah Sakit Mata Pekanbaru

The Pekanbaru Eye Hospital Eye Center (PBEC) is one of the Eye Hospitals that is quite famous in the city of PekanBaru in particular and in Riau Province in general. It is a tertiary hospital located in the northern part of Indonesia. The eye hospital industry has a great impact on the quality of eye health services. This study aims to investigate how HR at PBEC Eye Hospital is managed to achieve high productivity and positive outcomes, such as consumer satisfaction and hospital business performance, positing that effective HR governance leads to better results, while poor governance has negative impacts. This research has two primary objectives: to fulfill a graduation requirement at Bina Nusantara University, Jakarta, and to offer insights to eye hospital managers on the role of Human Resource Governance in hospital development, particularly at the eye hospital. The findings of this study will provide an in-depth understanding of how HR governance can support the progress of the hospital's business, as well as strategic steps to improve HR governance that have the potential to improve hospital performance. The suggestions submitted include improving the process and quality of HR governance through improving SOPs, training, consulting, and technology.

Improving Access to Specialist Eye Care for Indigenous Australians via Telehealth: An Observational Cohort Study.

Background: Indigenous people are often neglected in eye health research and service delivery programs, despite having a greater burden of vision loss, most of which is avoidable. The objective of this work was to improve access to specialist eye care for Indigenous Australians living in rural and remote areas, by providing direct access to expert diagnostic services based in metropolitan areas through a tele-ophthalmology system. Methods: Over a four-year study period, 13 remote communities in Queensland and the Northern Territory were identified that had limited or no access to eye screening services. Relationships with health service providers in the communities were established to codesign a sustainable model of service delivery and referral pathways to ensure that patients identified with eye issues received appropriate treatment. Results: Over the course of the study, screening records from 378 patients were uploaded to a web-based telehealth system and diagnosed by ophthalmologists. From these examinations, 64 new cases of diabetic retinopathy (DR) were identified (including 2 cases of proliferative DR and 4 cases of severe nonproliferative DR), and diabetic macular edema was noted in 18 patients. The majority of participants screened had no eye problems, which enables the removal of these patients from the queues of overwhelmed specialist lists, improving service efficiency. The study also demonstrates capacity building of healthcare workers to perform eye screening and improved patient health awareness where the retinal cameras were used as an educational tool. Conclusions: A valuable screening service has been established in the target areas, where access to ophthalmic services has been improved for residents of the study screening locations. Routine eye examination (instead of opportunistic eye examination) is feasible for early detection of some eye diseases for remote and rural patients.

Eye disorders associated with selective serotonin reuptake inhibitors: a real-world disproportionality analysis of FDA adverse event reporting system

ABSTRACT Background Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression and other psychiatric disorders. Despite their efficacy, there is a growing concern about the risk of eye disorders. This study aims to explore the potential correlation between eye disorders and SSRIs utilizing real-world data. Research design and methods The data were extracted from the US FDA Adverse Event Reporting System database from 2004Q1 to 2023Q3. The analysis focused on the clinical characteristics, the ranking of adverse reactions, the time-to-onset, and the severity proportion of SSRI-related eye disorders. Results Our analysis revealed that SSRIs were significantly associated with eye disorders, with a higher risk of vision blurred with escitalopram, angle closure glaucoma with citalopram, and photopsia with paroxetine. The most common eye disorders were vision blurred, visual impairment, mydriasis, etc. Most of these adverse events occurred within the first 30 days of treatment. The reported incidence of severe eye disorders was 38.6% for SSRIs, with fluoxetine exhibiting the highest rate at 45.9%. Conclusion Our study demonstrates a significant association between SSRIs and the risk of eye disorders. These findings provide crucial insights for clinicians when prescribing SSRIs and underscore the need to monitor eye health in patients receiving these medications.

Gene Therapy for Retinitis Pigmentosa: Current Challenges and New Progress.

Retinitis pigmentosa (RP) poses a significant threat to eye health worldwide, with prevalence rates of 1 in 5000 worldwide. This genetically diverse retinopathy is characterized by the loss of photoreceptor cells and atrophy of the retinal pigment epithelium. Despite the involvement of more than 3000 mutations across approximately 90 genes in its onset, finding an effective treatment has been challenging for a considerable time. However, advancements in scientific research, especially in gene therapy, are significantly expanding treatment options for this most prevalent inherited eye disease, with the discovery of new compounds, gene-editing techniques, and gene loci offering hope for more effective treatments. Gene therapy, a promising technology, utilizes viral or non-viral vectors to correct genetic defects by either replacing or silencing disease-causing genes, potentially leading to complete recovery. In this review, we primarily focus on the latest applications of gene editing research in RP. We delve into the most prevalent genes associated with RP and discuss advancements in genome-editing strategies currently employed to correct various disease-causing mutations.

Quality of Life Analysis of Primary Glaucoma Patients Based on Glaucoma Quality of Life-15 Score at Dr. Moewardi Hospital Surakarta

<p class="Default"><strong>Introduction: </strong>Visual acuity is vital for human's daily life. Glaucoma is a disease that affects visual acuity. In Indonesia, the number of glaucoma cases is quite high and its therapy focuses on eye health indicators. Whereas, Many studies have demonstrated that the quality of life of glaucoma patients diminishes. This research aimed to determine the quality of life of primary glaucoma patients in Dr. Moewardi hospital.</p><p class="Default"><strong>Method: </strong>This research was conducted using observational analytic method with cross sectional approach. Sampling process uses probability sampling with purposive sampling method. The subjects of this study were primary glaucoma patients in Dr. Moewardi hospital from July to November 2022. The sample size obtained from the formula was 38 people. Data were analyzed with independent t-test and one-way ANOVA. </p><p class="Default"><strong>Result: </strong>From the data analysis of GQL-15<strong> </strong>questionnaire's answer, it was found that there was a decrease in quality of life marked by higher GQL-15 questionnaire score in older patients, longer duration of diagnosis, partially or totally blind and no history of surgery. There was no increase in GQL-15 questionnaire result on patients with higher level of education. GQL-15 score in patients with longer duration of diagnosis (p-value = 0.011) and lower visual acuity (p-value = 0,000) was statistically significant.</p><p class="Default"><strong>Conclusion: </strong>Older patient groups, patients with longer duration of diagnosis, blind patients (unilateral or bilateral), and those who had not undergone glaucoma surgery has a worse quality of life. Patients’ visual acuity and duration of diagnosis are significantly correlated with their quality of life.</p>