Monopile foundations are known as the most common foundation solution for offshore wind turbines (OWTs). However, the state of practice for designing monopile foundations in high seismicity areas is still limited. In particular, the impact of soil liquefaction on the seismic soil-foundation-OWT interaction is not yet well understood. In this paper, three-dimensional (3D), fully-coupled, nonlinear finite-element analyses performed in the OpenSees numerical platform were used to evaluate the seismic performance of a series of hypothetical 5 MW OWTs on monopile foundations in layered, liquefiable sites. A suite of earthquake recordings with and without strong velocity pulses (i.e., near fault, pulse-like and ordinary motions, respectively) was used to investigate the impact of ground motion characteristics on the seismic response of the OWT system. Also, the influence of soil-structure interaction and earthquake shaking coupled with extreme environmental loading (i.e., wind and wave loads) on the seismic performance of soil-OWT systems was evaluated. The numerical results showed pile movements induced by extreme climate loading led to a bias in permanent settlement accumulation across the foundation area and accumulation of soil deformations in the proximity of the pile. Ground motion velocity pulses increased the cyclic stress demand in soil and, therefore, the potential for the occurrence of soil liquefaction. A subsequent, limited numerical sensitivity study showed that the foundation rotations of the OWT system were influenced by ground motion characteristics such as polarity and velocity pulses, and the presence of the wind and wave loads. The cumulative absolute velocity (CAV) was identified as the optimum ground motion intensity measure for permanent foundation settlement and tilt as well as for peak transient foundation tilt of the OWT system under extreme environmental loadings. The net outcome of these factors determined the magnitude and orientation of the foundation rotations at the end of shaking. This study highlights the importance of considering the effects of extreme loadings and pulse-like motions in the design and performance of OWT systems.