It is imperative to address the critical problem of water scarcity in sub-Saharan Africa, especially in light of the aggravating effects of climate change brought on by the extraction of fossil fuels. In order to ensure the availability of drinkable water in these places, this research proposes integrating concentrated solar power (CSP) with desalination systems (DS). Present research is focused on identifying and evaluating potential locations for DS/CSP implementation within Mauritania by employing a comprehensive, multi-criteria decision-making framework. This framework synthesizes mathematical approaches from multi-criteria analysis with geospatial analysis techniques, considering a range of factors including environmental impact, economic viability, demographic demands, and climatic conditions. Research findings reveal that 10% of the Mauritanian, approximately 103070 km2, presents optimal conditions for the deployment of DS/CSP facilities. The study delineates the coastal regions as prime candidates for seawater desalination plants, while the densely populated southeastern areas are identified as suitable for brackish water desalination systems. Conversely, the less inhabited northern territories hold the potential for decentralized brackish water desalination plants. Hence this study provides a holistic approach for DS/CSP systems installation to manage water scarcity as well as energy security issues in Mauritania. And also provides basis for formulating future policies in the region.