Objectives: Salt sensitivity is important cardiovascular risk factor. Commonly salt sensitivity detection methods include acute saline load test and chronic saline load test. Paolo Castiglioni assess the reliability of an easier approach based on data from 24-hour ambulatory blood pressure monitoring performed in hypertensive subjects during daily-life conditions and habitual diet. Our aim was to verify whether it is equally applicable to assess salt sensitivity in patients with hypertension in northeast China. Methods: We enrolled 17 mild to moderate hypertensive subjects in northeast China who underwent 24-hour ambulatory blood pressure monitoring during usual sodium intake. Patients were divided into 3 classes of sodium sensitivity risk on the basis of ambulatory blood pressure monitoring data: low risk if dippers and a 24-hour heart rate 70 bpm; high risk if nondippers and a 24-hour heart rate of 70 bpm; intermediate risk with the remaining combinations (dippers with heart rate 70 bpm or nondippers with heart rate 70 bpm). Then patients underwent a salt sensitivity test with rapid extracellular volume expansion with intravenous fluids and volume and sodium depletion induced by diuretic administration. Results: 9 sodium-sensitive patients were founded. The prevalence of sodium-sensitive patients increased significantly from the low-risk class (33%) to the intermediate-risk (50%) and high-risk (75%) classes. Conclusion: This easier protocol for assessing salt sensitivity is likely to be applicable to hypertensive patients in northeast China, if there is more data.