Helicobacter pylori (HP) infection is one of the most prevalent infections worldwide, contributing to inflammation of the gastric mucosa which is of great interest given its involvement in many gastroduodenal pathologies and some extra-digestive diseases. Aim of the Study: Report the incidence of HP from the endoscopy and anatomopathology register. Methods: This is a descriptive retrospective study performed during a period from January 2019 to November 2022, based on data from the endoscopy and anatomopathology register. We included all patients over 16 years of age who underwent esophago-gastroduodenal fibroscopy (EGD) with gastric biopsies performed according to the Sydney protocol. Results: 903 patients were included in our study. The incidence of HP infection was 60% (n=541).The average age was 50 years [17-90], the Sex Ratio W/M: 1.3, the most frequent symptom was represented by epigastralgia. The esophago-gastroduodenal fibroscopy had objectified an erythemato-congestive gastric mucosa in 481 (89%) of the cases, erythemato-whitish in 27 (5%), nodular in 16 (3%) and it was normal in 16 (3%) of the cases. On anatomopathological study, the gastritis was antro-fundal, antral and fundal in respectively 487 (90%), 43 (8%) and 11 (2%) of the cases. The intensity of gastritis was mild in 6.8%, moderate in 92% and severe in 1.2% of patients. Gastritis activity was absent in 6 (1.1%), mild in 74 (13.8%), moderate in 455 (84.1%) and severe in 5 (1%) cases. The density of HP was mild in 75 (14%), moderate in 437 (80.8%), and severe in 28 (5.2%) cases. Intestinal metaplasia was observed in only 9 cases (1.7%), as for dysplasia, it was not identified in any of our patients. Adenocarcinoma was revealed in 9 (1.7%) patients. Conclusion: The results of our study indicate an incidence of 60% (n=541). The association of chronic gastritis was important. Its pathogenic role has been revealed in many gastroduodenal pathologies in particular gastric cancer objectified in our series in 1.7% of cases, hence the interest in researching HP infection and its eradication.