Abstract The spiral-wound heat exchanger is a key equipment in the liquefied natural gas application, but the flow and heat transfer mechanisms remain unclarified. In this study, a three-dimensional numerical model is created, focusing on exploring the impact of four crucial structural parameters on the flow and heat transfer performance of natural gas, including the external diameter of tubes, the diameter of the core cylinder, the longitudinal pitch of tubes in the same layer, and the radial pitch of tube bundles between the adjacent layer. It was found that the tube diameter, core cylinder diameter, and radial pitch had significant effects on Nu and Δp m. The optimal Nu on the shell side was obtained at medium core cylinder size. The longitudinal pitch had a weak effect on the performance of both sides, and the longitudinal pitch corresponding to the maximum values of Nu and Δp m on both sides increased with the increase in the inlet Reynolds number. Under the effect of centrifugal force, a shifted tendency was shown by the velocity and temperature fields.