Abnormal vibration often occurs in the liquid oxygen kerosene transmission pipe- line of rocket engines, seriously threatening the safety of rocket engines. Improper handling will result in rocket launch failure and enormous economic losses. Therefore, the vibration of the transmission pipeline must be studied. In this paper, a three-dimensional high-pressure transmission pipeline model comprising a corrugated pipe, a multi-section bending pipe, and other auxiliary structures is established. Using the two-way fluid–solid coupling method, vibration analysis is performed on the pipeline under external pressure pulse excitation. The accuracy of the computation results is verified by a thermal test. Two vibration reduction strategies are presented and validated by simulation in accordance with the findings of the vibration study. The main conclusions are as follows: (1) At the same frequency, the amplitude distribution of vibration acceleration significantly correlates with the flow field pressure, indicating that fluid pressure fluctuation is the root cause of the abnormal vibration of the pipeline, and the vibration of the pipeline increases with the average pressure. (2) The time-average value and fluctuation amplitude of the larger stress and strain are mainly concentrated in the two supports, namely, the inside of the elbow and the bellows, which is different from the distribution of vibration acceleration. Such places are prone to structural failure and should be given attention. (3) The guide plate and the support enhancement method can reduce the vibration, but the support enhancement method has a better effect, reducing the vibration velocity and acceleration by 86.4% and 93%, respectively.