Objectives: 1) Develop simple cadaveric flow/pressure analysis system for experimental use for nasal procedure simulation. 2) Assess changes in nasal airway resistance in simulated inferior turbinate (IT) hypertrophy, normal state, and reduced, out-fractured conditions. Methods: An open thermodynamic nasal cavity experimental cadaveric model was created using an Omega HHP-103 digital manometer and oxygen flow regulator. For pressure testing, one pressure measurement catheter was placed at the internal nasal valve, isolating the nasal cavity from external nasal valve resistance. The second pressure measurement catheter was placed at the choana of the tested side, and the position was confirmed endoscopically. Repeatability was tested among nasal cavities, specimens, and repeat setups. Pressure measurements were taken incrementally between 0 and 25 liters per minute (Lpm) at each of three conditions: 1) control state, without augmentation, 2) simulated IT hypertrophy with 20% benzocaine topical anesthetic gel filler placed within sub-periosteal flap, and 3) out-fractured, reduced inferior turbinates. Results: The experimental system was simple to set up and repeatable. Experimentally, nasal airway resistance measurements revealed decreased resistance under control and out-fractured configuration versus hypertrophied turbinates. Initial studies trended, under all conditions, to have exponential growth of pressure as flow rate increased. Conclusions: The physiologically isolated test system allows anatomic manipulation and measurement of resulting pressure-flow relationships. IT alterations resulted in expected pressure-flow changes, indicating future analysis at other anatomic locations, such as olfactory epithelium, septum, or middle turbinate, is feasible.