External Fluctuations Research Articles

Gradient sensing by a bistable regulatory motif enhances signal amplification but decreases accuracy in individual cells

Many vital eukaryotic cellular functions require the cell to respond to a directional gradient of a signaling molecule. The first two steps in any eukaryotic chemotactic/chemotropic pathway are gradient detection and cell polarization. Like many processes, such chemotactic and chemotropic decisions are made using a relatively small number of molecules and are thus susceptible to internal and external fluctuations during signal transduction. Large cell-to-cell variations in the magnitude and direction of a response are therefore possible and do, in fact, occur in natural systems. In this work we use three-dimensional probabilistic modeling of a simple gradient sensing pathway to study the capacity for individual cells to accurately determine the direction of a gradient, despite fluctuations. We include a stochastic external gradient in our simulations using a novel gradient boundary condition modeling a point emitter a short distance away. We compare and contrast three different variants of the pathway, one monostable and two bistable. The simulation data show that an architecture combining bistability with spatial positive feedback permits the cell to both accurately detect and internally amplify an external gradient. We observe strong polarization in all individual cells, but in a distribution of directions centered on the gradient. Polarization accuracy in our study was strongly dependent upon a spatial positive feedback term that allows the pathway to trade accuracy for polarization strength. Finally, we show that additional feedback links providing information about the gradient to multiple levels in the pathway can help the cell to refine initial inaccuracy in the polarization direction.

The Effects of High Steady State Auxin Levels on Root Cell Elongation in Brachypodium

The long-standing Acid Growth Theory of plant cell elongation posits that auxin promotes cell elongation by stimulating cell wall acidification and thus expansin action. To date, the paucity of pertinent genetic materials has precluded thorough analysis of the importance of this concept in roots. The recent isolation of mutants of the model grass species Brachypodium distachyon with dramatically enhanced root cell elongation due to increased cellular auxin levels has allowed us to address this question. We found that the primary transcriptomic effect associated with elevated steady state auxin concentration in elongating root cells is upregulation of cell wall remodeling factors, notably expansins, while plant hormone signaling pathways maintain remarkable homeostasis. These changes are specifically accompanied by reduced cell wall arabinogalactan complexity but not by increased proton excretion. On the contrary, we observed a tendency for decreased rather than increased proton extrusion from root elongation zones with higher cellular auxin levels. Moreover, similar to Brachypodium, root cell elongation is, in general, robustly buffered against external pH fluctuation in Arabidopsis thaliana. However, forced acidification through artificial proton pump activation inhibits root cell elongation. Thus, the interplay between auxin, proton pump activation, and expansin action may be more flexible in roots than in shoots.

The Effects of High Steady State Auxin Levels on Root Cell Elongation in Brachypodium.

The long-standing Acid Growth Theory of plant cell elongation posits that auxin promotes cell elongation by stimulating cell wall acidification and thus expansin action. To date, the paucity of pertinent genetic materials has precluded thorough analysis of the importance of this concept in roots. The recent isolation of mutants of the model grass species Brachypodium distachyon with dramatically enhanced root cell elongation due to increased cellular auxin levels has allowed us to address this question. We found that the primary transcriptomic effect associated with elevated steady state auxin concentration in elongating root cells is upregulation of cell wall remodeling factors, notably expansins, while plant hormone signaling pathways maintain remarkable homeostasis. These changes are specifically accompanied by reduced cell wall arabinogalactan complexity but not by increased proton excretion. On the contrary, we observed a tendency for decreased rather than increased proton extrusion from root elongation zones with higher cellular auxin levels. Moreover, similar to Brachypodium, root cell elongation is, in general, robustly buffered against external pH fluctuation in Arabidopsis thaliana However, forced acidification through artificial proton pump activation inhibits root cell elongation. Thus, the interplay between auxin, proton pump activation, and expansin action may be more flexible in roots than in shoots.

Is fiscal devaluation welfare enhancing?

Due to the experience of large external imbalances and misaligned real exchange rates within the euro area, the concept of fiscal devaluation has gained increasing attention, which mimics the effects of external devaluation in the absence of flexible nominal exchange rates and an independent monetary policy. This paper uses a small open economy model with nominal wage and price rigidities to analyse the welfare effects of fiscal devaluation, understood as budgetary-neutral tax shift from employers' social security contributions towards consumption tax. The paper finds that fiscal devaluation can support external rebalancing by accelerating real exchange rate adjustments and regaining price competitiveness. From a household welfare perspective, internal devaluation with its concomitant worsening of the terms of trade tends to induce welfare losses. The overall welfare effects are pro-cyclical in the sense that the stronger the tax shift, the higher the welfare losses for the average household. The losses increase with the openness of the economy and the relative size of the tradable sector. In the presence of supply shocks, however, fiscal devaluation can imply small welfare gains. A scenario with flexible nominal exchange rates and autonomous monetary policy performs better in terms of household welfare, but implies stronger external fluctuations in the short run.

Channel based generating function approach to the stochastic Hodgkin-Huxley neuronal system.

Internal and external fluctuations, such as channel noise and synaptic noise, contribute to the generation of spontaneous action potentials in neurons. Many different Langevin approaches have been proposed to speed up the computation but with waning accuracy especially at small channel numbers. We apply a generating function approach to the master equation for the ion channel dynamics and further propose two accelerating algorithms, with an accuracy close to the Gillespie algorithm but with much higher efficiency, opening the door for expedited simulation of noisy action potential propagating along axons or other types of noisy signal transduction.

Experimental comparison of a wind-turbine and of an actuator-disc near wake

The actuator disc (AD) model is commonly used to simplify the simulation of horizontal-axis wind-turbine aerodynamics. The limitations of this approach in reproducing the wake losses in wind farm simulations have been proven by a previous research. The present study is aimed at providing an experimental analysis of the near-wake turbulent flow of a wind turbine (WT) and a porous disc, emulating the actuator disc numerical model. The general purpose is to highlight the similarities and to quantify the differences of the two models in the near-wake region, characterised by the largest discrepancies. The velocity fields in the wake of a wind turbine model and a porous disc (emulation of the actuator disc numerical model) have been measured in a wind tunnel using stereo particle image velocimetry. The study has been conducted at low turbulence intensity in order to separate the problems of the flow mixing caused by the external turbulence and the one caused by the turbulence induced directly by the AD or the WT presence. The analysis, as such, showed the intrinsic differences and similarities between the flows in the two wakes, solely due to the wake-induced flow, with no influence of external flow fluctuations. The data analysis provided the time-average three-component velocity and turbulence intensity fields, pressure fields, rotor and disc loading, vorticity fields, stagnation enthalpy distribution, and mean-flow kinetic-energy fluxes in the shear layer at the border of the wake. The properties have been compared in the wakes of the two models. Even in the absence of turbulence, the results show a good match in the thrust and energy coefficient, velocity, pressure, and enthalpy fields between wind turbine and actuator disc. However, the results show a different turbulence intensity and turbulent mixing. The results suggest the possibility to extend the use of the actuator disc model in numerical simulation until the very near wake, provided that the turbulent mixing is correctly represented.

Dynamic Analysis of Wind Turbine Gearbox Components

This paper studies the dynamic response of a wind turbine gearbox under different excitation conditions. The proposed 4 degree-of-freedom (DOF) dynamic model takes into account the key factors such as the time-varying mesh stiffness, bearing stiffness, damping, static transmission error and gear backlash. Both the external excitation due to wind and the internal excitation due to the static transmission error are included to represent the gearbox excitation conditions. With the help of the time history and frequency spectrum, the dynamic responses of wind turbine gearbox components are investigated by using the numerical integration method. This paper explains under which conditions the fretting corrosion, as one of the wind turbine gearbox failure modes, may occur. Furthermore, it is observed that the external excitation fluctuation has large influence on the dynamic responses of both the gears and bearings.

Common property organisations as actors in rural development: a case study of a mountain area in Italy

The Consorzi Vicinali are common property organisations (CPOs) located in a mountain area of Friuli Venezia Giulia region, in North East Italy. These CPOs have a long history of mutual assistance and collective use and management of local resources, thus contributing to a balanced development of the local community and territory. The research aimed at investigating whether these historical CPOs still have a relevant role to play in the development of local rural areas, and how they deal with the present needs and opportunities of these areas. Specifically, the robustness and viability of these organisations were analysed. The survey revealed some strengths and weaknesses of the Consorzi Vicinali. According to Ostrom’s design principles, the robustness is quite high. Nevertheless, this ability to maintain some desired characteristics despite internal and external fluctuations does not always match with a high viability, in terms of natural resource management, internal participation, creation of job opportunities especially for young people, and capacity to attract financial support. In fact, some Consorzi still act effectively in terms of the collective stewardship of rural resources. Whereas, others have the potential to adapt to new challenges and emerging needs, due to the deep rootedness and the sense of belonging of the local community to its territory. These are the strengths of all the Consorzi. The robustness and viability analyses used in a complementary way have been effective here in giving a more comprehensive description of CPOs and their (potential) role in rural development.

Design verification of large time constant thermal shields for optical reference cavities.

In order to achieve high frequency stability in ultra-stable lasers, the Fabry-Pérot reference cavities shall be put inside vacuum chambers with large thermal time constants to reduce the sensitivity to external temperature fluctuations. Currently, the determination of thermal time constants of vacuum chambers is based either on theoretical calculation or time-consuming experiments. The first method can only apply to simple system, while the second method will take a lot of time to try out different designs. To overcome these limitations, we present thermal time constant simulation using finite element analysis (FEA) based on complete vacuum chamber models and verify the results with measured time constants. We measure the thermal time constants using ultrastable laser systems and a frequency comb. The thermal expansion coefficients of optical reference cavities are precisely measured to reduce the measurement error of time constants. The simulation results and the experimental results agree very well. With this knowledge, we simulate several simplified design models using FEA to obtain larger vacuum thermal time constants at room temperature, taking into account vacuum pressure, shielding layers, and support structure. We adopt the Taguchi method for shielding layer optimization and demonstrate that layer material and layer number dominate the contributions to the thermal time constant, compared with layer thickness and layer spacing.

Universal evolution of a viscous–capillary spreading drop

The rate of spreading or retraction of a drop on a flat substrate is determined through a balance of surface tension and hydrodynamic flow. While asymptotic regimes are known, no general rate equation has hitherto been available. Here, we revisit this classic problem, in a regime governed by capillary and viscous forces, by performing an exhaustive numerical study of drop evolution as a function of the contact angle with the substrate. Our study reveals a universal evolution of the drop radius parameterised only by the substrate wettability. Two limits of this evolution recover the familiar exponential and algebraic regimes. Our results show quantitative comparison with the evolution derived from lubrication theory, indicating that dissipation at the contact line is the key determinant in drop evolution. Our work, both numerical and theoretical, provides a foundation for studying the full temporal dynamics of droplet evolution under the influence of external fields and thermal fluctuations, which are of importance in nanofluidics.

''DOUBLE-HUMPED EFFECT'' IN THE TURBULENT COLLISION MAGNETIZED PLASMA

Statistical moments of the spatial power spectrum of multiple scattered ordinary and extraordinary waves in the turbulent collision magnetized plasma with aligned anisotropic electron density irregularities are investigated using modify smooth perturbation method taking into account diffraction effects. Correlation function and variances of the phase fluctuations are obtained for arbitrary correlation function of the electron density fluctuations. Double-humped Effect is investigated analytically and numerically using the anisotropic Gaussian spectral function of electron density irregularities for the polar ionospheric F-region applying the experimental data. Investigation of the anisotropy of the F layer irregularities is of great interest in ionospheric physics. It is well known that the irregularities are elongated in the direction of the geomagnetic field of lines, but especially at high latitudes they are also found to be anisotropic in the plane perpendicular to the external magnetic field vector. The anisotropy is usually investigated by correlation analysis of radio signals from satellites, observed by space receiver on the ground. The fluctuations in amplitude and phase (scintillations) of radio waves passing through the ionosphere are caused by spatial irregularities in the electron density. The spatial fluctuations in phase cause fluctuations of the angle of arrival at the observation points. Broadening of the spatial power spectrum (SPS) of scattered electromagnetic (EM) waves in the turbulent collision magnetized plasma for both power-law and anisotropic Gaussian correlation functions of electron density fluctuations was analyzed in (1) using the complex ray (-optics) approximation. Double-humped Effect, the features of the SPS, spectral width and shift of its maximum of multiple scattered EM waves in the turbulent collisionless magnetized plasma were considered in (2, 3). The influence of the collision frequency between plasma particles on the statistical characteristics of scattered EM waves in the turbulent magnetized plasma with both electron density and external magnetic field fluctuations was investigated in (4). The present paper reports the results of an analysis of the SPS, which is related to fluctuations of the radio refractive index in the F region. Analytical expressions of the correlation function of phase fluctuations of scattered both ordinary and extraordinary waves are obtained for the arbitrary correlation functions of electron density fluctuation using modify smooth perturbation method taking into account the diffraction effects. The Double-humped Effect in the collision magnetized plasma with elongated electron density irregularities is considered for the first time. Formation of a gap in the SPS of scattered radiation is analyzed numerically for the polar ionospheric F -region using the anisotropic Gaussian spectral function of electron density fluctuations. This spectrum contains angle of aligned plasma irregularities to the direction of an external magnetic field and anisotropy factor. The numerical calculation is computed based on experimental data. Finally, paper concludes the obtained results and their significance.

On the transmission of waves at discrete frequencies from the solar wind to the magnetosphere and ground: A case study

AbstractWe analyze a case event in which several fluctuations at discrete frequencies (f ≈ 1.3–1.5, 3.3–3.6, 4.4–4.6, and 5.9–6.2 mHz; i.e., close to the “CMS” frequencies) were observed in the magnetosphere, after the impact of a sharp shock wave that, in the interplanetary medium, was followed by intense fluctuations in the solar wind parameters. The comparison between interplanetary, geosynchronous, and ground‐based observations revealed that following the Sudden Impulse, magnetospheric modes at the same discrete frequencies were detected at geostationary orbit by spacecraft located in the morning and the dawn sector, and, ubiquitously, at ground‐based stations: all of them revealed a one‐to‐one correspondence with those ultimately identified in the high‐velocity stream following the shock wave. It reveals that the occurrence of such global modes is directly related to the transmission of external fluctuations and the observed geomagnetic fluctuations might be interpreted as the ground magnetic response to magnetospheric compressional modes forced by oscillations of the solar wind pressure at the same frequencies. By contrast, we did not find any evidence for magnetospheric oscillations possibly related to other mechanisms such as the velocity shear, the impact of the shock wave itself, etc.

ANALISIS SEKTOR-SEKTOR UNGGULAN DALAM MENGGERAKKAN SEKTOR RIIL

External fluctuation happened on global economy could be anticipated by Indonesia Government through a good coordination between fiscal and monetary policy. It is reflected from the Indonesia's positive economic growth on 2009 which reached 4,5 percent. But Indonesia's economic growth acceleration still retained by the low activity on real sector, so worried about the creation ofsustainable economic growth. Regarding that, it needs priority sharpening for sectors which has superiority on motivating the economy.To answer the problem, this article seek to identify business sectors which has superiority within economy and to formulate the policy needed to develop those sectors. The analysis is done by using Input Output table with baclcward linkage and forward linkage approach. Because of the limited data source, the analysis only from year 2000 until 2005.The output shows that there are 6 (six) sectors which has superiority within economy, that is Chemical Industry, Pesticide Fertilizer Industiy, Other Food industry, Rubber and Pesticide Industry, All-kind of Flour Industry, and Water, Gas and Electricity. For those superior sectors needs to be done a priority program thorugh budget spending policy.

Two-dimensional motion of Brownian swimmers in linear flows.

The motion of viruses and bacteria and even synthetic microswimmers can be affected by thermal fluctuations and by external flows. In this work, we study the effect of linear external flows and thermal fluctuations on the diffusion of those swimmers modeled as spherical active (self-propelled) particles moving in two dimensions. General formulae for their mean-square displacement under a general linear flow are presented. We also provide, at short and long times, explicit expressions for the mean-square displacement of a swimmer immersed in three canonical flows, namely, solid-body rotation, shear and extensional flows. These expressions can now be used to estimate the effect of external flows on the displacement of Brownian microswimmers. Finally, our theoretical results are validated by using Brownian dynamics simulations.

Electron dynamical response in InP semiconductors driven by fluctuating electric fields

The complexity of electron dynamics in low-doped n-type InP crystals operating under fluctuating electric fields is deeply explored and discussed. In this study, we employ a multi-particle Monte Carlo approach to simulate the non-linear transport of electrons inside the semiconductor bulk. All possible scattering events of hot electrons in the medium, the main details of the band structure, as well as the heating effects, are taken into account. The results presented in this study derive from numerical simulations of the electron dynamical response to the application of a sub-Thz electric field, fluctuating for the superimposition of an external source of Gaussian correlated noise. The electronic noise features are statistically investigated by computing the correlation function of the velocity fluctuations, its spectral density and the variance, i.e. the total noise power, for different values of amplitude and frequency of the driving field. Our results show the presence of a cooperative non-linear behavior of electrons, whose dynamics is strongly affected by the field fluctuations. Moreover, the electrons self-organize among different valleys, giving rise to the reduction of the intrinsic noise. This counterintuitive effect critically depends on the relationship among the characteristic times of the external fluctuations and the temporal scales of complex phenomena involved in the electron dynamical response. In particular, the correlation time of the electric field fluctuations appears to be crucial both for the noise reduction effect and the appearance of an anomalous diffusion effect.

LANGMUIR WAVE DECAY IN INHOMOGENEOUS SOLAR WIND PLASMAS: SIMULATION RESULTS

Langmuir turbulence excited by electron flows in solar wind plasmas is studied on the basis of numerical simulations. In particular, nonlinear wave decay processes involving ion-sound (IS) waves are considered in order to understand their dependence on external long-wavelength plasma density fluctuations. In the presence of inhomogeneities, it is shown that the decay processes are localized in space and, due to the differences between the group velocities of Langmuir and IS waves, their duration is limited so that a full nonlinear saturation cannot be achieved. The reflection and the scattering of Langmuir wave packets on the ambient and randomly varying density fluctuations lead to crucial effects impacting the development of the IS wave spectrum. Notably, beatings between forward propagating Langmuir waves and reflected ones result in the parametric generation of waves of noticeable amplitudes and in the amplification of IS waves. These processes, repeated at different space locations, form a series of cascades of wave energy transfer, similar to those studied in the frame of weak turbulence theory. The dynamics of such a cascading mechanism and its influence on the acceleration of the most energetic part of the electron beam are studied. Finally, the role of the decay processes in the shaping of the profiles of the Langmuir wave packets is discussed, and the waveforms calculated are compared with those observed recently on board the spacecraft Solar TErrestrial RElations Observatory and WIND

Mechanical fluctuations suppress the threshold of soft-glassy solids: The secular drift scenario

We propose a dynamical mechanism leading to the fluidization by external mechanical fluctuations of soft-glassy amorphous material driven below the yield stress. The model is based on the combination of memory effect and nonlinearity, leading to an accumulation of tiny effects over a long term. We test this scenario on a granular packing driven mechanically below the Coulomb threshold. We provide evidence for an effective viscous response directly related to small stress modulations in agreement with the theoretical prediction of a generic secular drift. We propose to extend this result more generally to a large class of glassy systems.

Spatial and temporal fluctuations of the abundance of Neotropical cave-dwelling moth Hypena sp. (Noctuidae, Lepidoptera) influenced by temperature and humidity

The present study evaluated the seasonal variation of a population of Hypena sp. in the Gruta Taboa (Sete Lagoas, Minas Gerais, Brazil), in relation to changes in temperature and humidity during the dry (July 1999 and July 2000) and rainy (January 2000 and January 2001) seasons. The Hypena sp. population responded to external seasonality, being distributed closer to the cave entrance during the rainy season, in which temperature and humidity fluctuated around 21 °C and 85%, respectively. During the dry season abundance was higher in sections farther from the entrance (deeper sections) (19.2 °C temperature and 80% humidity). The results showed that this species is influenced by external environmental factors, even in a tropical region where the external climate fluctuations are lower compared to temperate regions.

Mathematical model of thermal shields for long-term stability optical resonators.

Modern experiments aiming at tests of fundamental physics, like measuring gravitational waves or testing Lorentz Invariance with unprecedented accuracy, require thermal environments that are highly stable over long times. To achieve such a stability, the experiment including typically an optical resonator is nested in a thermal enclosure, which passively attenuates external temperature fluctuations to acceptable levels. These thermal shields are usually designed using tedious numerical simulations or with simple analytical models. In this paper, we propose an accurate analytical method to estimate the performance of passive thermal shields in the frequency domain, which allows for fast evaluation and optimization. The model analysis has also unveiled interesting properties of the shields, such as dips in the transfer function for some frequencies under certain combinations of materials and geometries. We validate the results by comparing them to numerical simulations performed with commercial software based on finite element methods.

Resonance Frequency of Bubble Pulsations (Approximate Solution)

The problem of bubble pulsations in a volume of a quiescent liquid with periodic external pressure fluctuations has been considered in a linear approximation. The incorrectness of the use of a polytropic approximation is shown. An approximate analytical solution for the resonance frequency of pulsations has been obtained.