Lamy and Maroteaux (9) recently reported 3 cases of a generalized osseous developmental anomaly, comprising dwarfism, clubfoot deformity, and scoliosis. They collected 11 similar cases from the literature, in some of which deformity of the external ears and cleft palate were also present. From their review of the 14 cases, they concluded that these were examples of the same disease, a distinct entity which should be differentiated from achondroplasia and other osseous dysplasias. They chose the term “nanisme diastrophique” (tortuous dwarfism) because of the clubfoot deformity and scoliosis. This report presents the histories of 2 sisters with clinical and roentgenographic findings similar to those described by Lamy and Maroteaux. Case Histories Case I: Minnie P., a 7-year-old white girl of European extraction, was born at full term after an uneventful pregnancy. Delivery was normal. The birth weight was 3,890 gm. and the height 46 cm. Immediately after birth, cleft palate, cavernous hemangioma of the right external ear, short extremities, and foot deformities were noted. At five weeks of age, radiotherapy was given to the right ear. The patient was slow in physical growth and development. She could not turn over until fourteen months of age and did not walk until she was about twenty-six months old. Toilet training was delayed because of her inability to sit up properly. Though the child was intelligent, her speech was poor because of the cleft palate. Deformity of the hips and feet was progressive, and a gradual increase in the posterior and upward tilting of the buttocks and flexion of the knees made her gait difficult. Admission to Children's Memorial Hospital was on Jan. 25, 1961, for correction of the cleft palate. Multiple deformities of the trunk and extremities were noted, and the diagnosis of arthrogryposis or achondroplasia was clinically entertained. Physical Examination and Laboratory Findings: The patient was a short, stocky girl (Fig. 1) with obviously short extremities, who walked on her toes with knees and hips in a semiflexed position. Her weight was 18 kg., her height 94 cm.; the head circumference was 54.5 cm. The right external ear was deformed and was the site of previous radiotherapy. The left external ear appeared to be normal. The soft and hard palates were almost completely absent. Dental malocclusion was present. All joints showed limitation of range of motion to a moderate degree. This was most marked in the hands, hips, knees, and feet. The elbows, the hips, and the knees were in semiflexion and could not be completely extended. The tendons at the joint regions appeared to be short, resistant to passive motion beyond certain limits, and tense. The distal phalanges of the hands were in slight flexion and could not be fully extended. The feet were small and in equinovarus position. Hemoglobin was 13.8 gm., serum calcium was 11 mg. per cent, and serum phosphorus was 4.4 mg. per cent.