To evaluate the safety and efficacy of thermotherapy combined radical radiotherapy concurrent chemotherapy for Ib2, IIa and local advanced cervical cancer. 30 patients diagnosed with cervical cancer from Jan 1, 2016 to Dec 31, 2017 were retrospectively studied. Among the patients, 1 pathologic diagnosed adenocarcinoma and 29 of squamous cell carcinoma; FIGO stage Ib2 10 patients and IIa-IVa 20 patients. All patients underwent radical chemotherapy concurrent radiotherapy (CCRT). Radiation composed of pelvic external beam radiation (EBRT) (50.4Gy/1.8Gy/28f 5f/w, EQD2=45Gy) and brachytherapy ( 6Gy/f 5f 2f/w, EQD2=40Gy) concurrent chemotherapy of DDP 40mg/m2 weekly, 6 weeks, total 55 days of treatment procedure. Hyperthermia (SR 1000 RF applicator, Xianke medical equipment co. LTD, Shenzhen ,China) were applied for these group of patients during the CCRT . Deep heating through the thermode to the tumor location 40.5~41°C 60 minutes twice a week, longer than 72hours interval. The temperature were read by the sensor which placed into the vagina. Objective response rate (ORR), time to progression (TTP) and side effects were analyzed. 30 patients median age 53 years old (39- 83y). Median follow up time was 16.5 months (9- 28ms). Mean maximum tumor diameter of primary cervical cancer was 4.37±0.28cm (2-8.3cm). ORR of end of EBRT before brachytherapy is 73% (CR+PR,22/30) and 4 patients CR; ORR of 1 months later after completion of CCRT is 96% (CR+PR,29/30) and 17 patients CR; ORR of 6 months later after completion of CCRT is 96% (CR+PR,29/30) and 20 patients CR. Mean local control time is 24.2±1.54 months (95% Confidence Interval 21.2ms-27.3ms), Median TTP was 15 months (3- 28ms), 1y and 2y local control rate was 83.3%. By the end of follow-up, 5 patients relapse in pelvic, 2 patients died because of distant metastasis. Early side effects of grade 1/2 myelosuppression was seen in 28 patients ( 93%), grade 4 myelosuppression was seen in 2 patients (7%). There were no grade 3/4 rectitis and grade 3/4 urethritis were observed. Thermotherapy Combined Radical CCRT for bulky Local Advanced Cervical Cancer is safe and effective and still need further investigation.