External Agents Research Articles

Hyper-Cross-Linked Porous Polymer Featuring B-N Covalent Bonds (HCP-BNs): A Stable and Efficient Metal-Free Heterogeneous Photocatalyst.

The first example of a porous polymer containing B-N covalent bonds, prepared from a tetraphene B-N monomer and biphenyl as a comonomer, is reported. It was prepared using the solvent knitting strategy, which allows the connection between the aromatic rings of the two monomers through methylene groups provided by an external cross-linking agent. The new polymer exhibited micromeso porosity with an SBET of 612 m2/g, high thermal stability, and potential properties as a heterogeneous photocatalyst, since it is very active in the aza-Henry coupling reaction (>98% of conversion and selectivity). After the first run, the catalyst improves its photocatalytic activity, shortening the reaction time to only 2 h and maintaining this activity in successive runs. The presence of a radical in this structure that remains stable with successive runs makes it a new type of material with potential applications as a highly stable and efficient photocatalyst.

Transparent Figures: Researching and Preserving Objects of Cellulose Acetate

In 1935, the Deutsches Hygiene-Museum Dresden began to produce the so-called Transparent Figures, which became icons of the 20th century. This study aims to explore the effects of external agents such as humidity and temperature on the aging mechanism of the materials of the Transparent Figures and to slow it down through preventive measures. The focus is on cellulose acetate (CA), which was used for the outer skin of the Transparent Figures. The original objects were investigated using FTIR, Raman, and GC–MS. On some Transparent Figures, liquid leakage of additives occurs when the relative humidity rises above 50–60% RH and is accompanied by a release of acetic acid. Based on these findings, original CA used for the production of the Transparent Figures was artificially re-aged at 70 °C while varying the relative humidity. The specimens were analyzed with colorimetry and GC–MS. Additive content, degree of substitution and degree of polymerization were determined. The results showed that the degradation is slowed down at 30% RH compared to aging at 50% RH or 70% RH. Thus, lowering the relative humidity seems effective in slowing down the degradation of the CA of the Transparent Figures. A relative humidity of 30% RH and a temperature of 15 °C are recommended.

P-229 Prospective comparative study between two commercial heavy oils for culture using sibling donor oocytes collected

Abstract Study question To compare embryo development and clinical outcomes between two commercial heavy oils using sibling donor oocytes collected. Summary answer Our study suggests that both commercial heavy oils achieve similar embryo development and clinical outcomes rates. What is known already Current tendencies in IVF laboratories, such as extending the embryo culture uninterruptedly until day 6/7 or the use of dry time-lapse incubators, have enhanced the importance to use good quality oils supporting human embryo culture in vitro. The coating of the culture dishes with oil is highly important to maintain the ideal conditions that embryos need for an optimal development. Specifically, oil plays an essential role in maintaining a stable temperature, provides a barrier against external agents and contributes preventing the media evaporation, and thus, to the maintenance of an optimal pH and osmolality for the correct embryo development. Study design, size, duration This is a single-centre prospective study performed between February and November 2022 that included 180 donors and 213 recipients. Donors were randomized using a computer-generated randomization list. Each case was processed and cultured with a commercial single medium coated with a layer of the commercial heavy oil assigned, a mineral oil (A) or a paraffin oil (B). Participants/materials, setting, methods Oocytes were injected by ICSI and then cultured in 16-well dishes (EmbryoSlide+®, EmbryoScope+™,Vitrolife) prepared with each heavy oil (1700µl oil/dish). These were cultured in a time-lapse incubator (EmbryoScope+™,Vitrolife) at 37.29 ± 0.05 °C in an atmosphere of 6.5% CO2 and 5% O2. These parameters were controlled periodically (T+Button,BrightSentinel and G100,Geotech). Laboratory conditions, such as temperature, humidity and volatile organic compounds levels were monitored continuously (Octax Log&Guard™,Vitrolife) during the study period, and pH was measured in a weekly basis. Main results and the role of chance A total of 2554 MII oocytes were injected by ICSI (oil A, n = 1304 and oil B, n = 1250). The proportion of fertilized oocytes was identical between the two oils (A:80.00% vs B:80.53%), as well as, abnormal fertilized oocyte rate (A:6.85% vs B:5.62%) and oocyte degeneration rate post-ICSI (A:6.14% vs B:6.00%). The mean number of embryos that reached the blastocyst stage and the proportion of blastocysts suitable for clinical use (transferred or cryopreserved) was almost the same independently of the oil used (A:69.84% vs B:67.15% and A:62.39% vs B:60.71%, respectively). Statistical data analysis was performed without referring to statistical significance (p > 0,05). 205 patients had an embryo transfer on day 5/6 with either fresh or cryopreserved blastocysts cultured coated with a layer of oil A (n = 101) or B (n = 104), with a mean number of 1.42 ± 0,55 and 1.33 ± 0,53 blastocysts transferred/patient in each group, respectively. No differences were found in terms of clinical pregnancy (A:69.30% vs B:67.31%) or implantation rates (A:62.37% vs B:61.53%) between both groups. Miscarriage rates were similar between group A (11.88%) and group B (12.62%). The pH average value during the study was 7.26 ± 0.06. The mean values of the room temperature, humidity and VOCs were stable at 21.7 ± 0.4 °C, 66.7 ± 6.9% and 0.098 ± 0.01ppm, respectively. Limitations, reasons for caution Although heavy oils are the most competent in keeping optimal culture conditions over time, there are several culture oils with different features available in IVF market. Thus, further studies should be performed comparing among them. Future research is also needed to compare peroxidation rates of our culture oils studied. Wider implications of the findings The present study suggests that both commercial heavy oils used in a continuous approach may provide similar in vitro fertilization rates regarding fertilization, blastocysts suitable for clinical use or clinical pregnancy. Heavy oil features, laboratory conditions and the culture environment should be properly validated independently on each IVF center. Trial registration number not applicable

Leveraging Artificial Intelligence for Targeted Response in Allergic Rhinitis

One step further to Bioinformatics is Artificial intelligence (AI) and data analysis, one would wonder how we can apply AI in the area of aeroallergens’ interactions in Allergic rhinitis (AR). Allergic rhinitis, also known as hay fever, is a common condition that affects millions of people worldwide. It is characterized by the inflammation of the nasal passages due to an immune response triggered by allergens such as pollen, dust mites, and animal dander and many more aeroallergens. Allergic rhinitis is a growing public health, medical and economic problem worldwide. The treatment of allergic rhinitis involves the use of drugs, such as antihistamines, decongestants, and corticosteroids, which can interact with genes and affect the way they work. For example, drug metabolism can be influenced by polymorphic genes which are the first line of action to an external agent like drugs. Some people may metabolize drugs faster or slower than others due to their genetic make-up. While some people may have a genetic variant that makes them less able to metabolize antihistamines, which can lead to side effects such as drowsiness and dry mouth as it happens in AR. While traditional treatments exist, the emergence of artificial intelligence (AI) offers new opportunities for targeted and personalized interventions. This article explores the potential applications of AI in the management of allergic rhinitis and how it can improve patient outcomes. The symptoms of allergic rhinitis can significantly impact a person's quality of life, leading to sneezing, congestion, itching, and nasal discharge and affecting their daily routine.

Diseño y elaboración de un sérum facial con <em>Lactobacillus fermentum</em> CECT 5716

Introduction: The skin is of all the organs of the body that is directly and constantly exposed to external agents. Hence the importance of providing all the necessary nutrients to keep it healthy, cared for and hydrated. When this does not happen, the skin begins to lose water, becomes dehydrated, and can be seriously injured. With this intention, a moisturizing serum with natural active ingredients has been designed and developed. It has been developed and characterized through various studies. In addition, it includes a strain of the probiotic species Lactobacillus fermentum CECT 5716, as an innovation, to enhance the synergistic effect of the product. Method: The cited product is characterized by pH, conductivity, and viscosity measurements to test its stability. Besides it is studied to probiotic viability and consumers’ perception of the product’s efficacy. Results: Data extracted from pH and conductivity measurements assure that the topical application of our serum is safe, as it does the consumers’ perception of the product’s efficacy study, offering it a better appearance in terms of smoothness and luminosity. This research has revealed the serum’s pseudoplastic characteristics, optimal for its purpose. Lastly, it has been seen that probiotic viability decreases with time. Conclusions: Based on the results we obtained; it can be affirmed that our moisturizing serum is safe and effective in skin hydration, due to the properties of the raw materials incorporated and the competitive mechanism of the probiotics included.

AMERICAN POLICY OF INTERVENTIONISM: AN OVERVIEW

Interventionism lacks any proper definition. It is a broad term used for non-defensive proactive policy undertaken by any nation-state to manipulate an economy or society. The most common applications of the term are for economic intervention when a state intervenes in its own economy, or for foreign intervention when a state intervenes in the affairs of another nation as part of its foreign policy. Ever since the Westphalian order of 1644, which accepted the concept of the sovereignty of nation-states on their territory, with no role for external agents in domestic structures, sovereignty has never truly been violable, but in early 20th century the social purpose of the use of force began to expand and marked a new idealism in the use of war. It produced mixed opinions of critics and generated a wide discourse on whether it is a ‘mask’ to some surreptitious motives, or is a ‘Just Intent’in real world terms

Evolution of YacG to safeguard DNA gyrase from external perturbation

Cells have evolved strategies to safeguard their genome integrity. We describe a mechanism to counter double strand breaks in the chromosome that involves the protection of an essential housekeeping enzyme from external agents. YacG is a DNA gyrase inhibitory protein from Escherichia coli that protects the bacterium from the cytotoxic effects of catalytic inhibitors as well as cleavage-complex stabilizers of DNA gyrase. By virtue of blocking the primary DNA binding site of the enzyme, YacG prevents the accumulation of double strand breaks induced by gyrase poisons. It also enables the bacterium to resist the growth-inhibitory property of novobiocin. Gyrase poison-induced oxidative stress upregulates YacG production, probably as a cellular response to counter DNA damage. YacG-mediated protection of the genome is specific for gyrase targeting agents as the protection is not observed from the action of general DNA damaging agents. YacG also intensifies the transcription stress induced by rifampicin substantiating the importance of gyrase activity during transcription. Although essential for bacterial survival, DNA gyrase often gets entrapped by external inhibitors and poisons, resulting in cell death. The existence of YacG to specifically protect an essential housekeeping enzyme might be a strategy adopted by bacteria for competitive fitness advantage.

Particle interaction strengths modified by magnetic fields

AbstractMagnetic fields are everywhere in the Universe and in our everyday life and many processes are affected by their presence, generating a rich phenomenology that depends also on other possible external agents. We review here some results, both from our workgroup and from other research groups, about the effect of magnetic fields on particles interaction processes, focusing mainly on recent results, but without losing sight on early seminal works on this topic. A vast assortment of physical situations and of analytical and numerical approaches can be found in the literature in this subject, making the comparison between them not straightforward. Our aim is to focus attention on differences and similarities between the different situations and approaches, looking for a systematization scheme that could be predictive, once the role played by each physical ingredient could be understood. The main purpose of this work is to find some physical explanations of the ongoing processes.

Influence of an innovative, biodegradable active packaging on the quality of sunflower oil and “pesto” sauce during storage

The aim of this research was to produce an innovative, biodegradable multilayer active packaging solution, with excellent oxygen barrier properties, to extend shelf- life of oily foods. In fact, one of the main drawbacks of biodegradable films is the low barrier they offer against external agents that can thus easily accelerate the foods degradation during shelf-life. In this study, a multilayer material obtained by the adhesion of two polylactic acid (PLA) films with cold plasma application, in place of synthetic adhesives, was realized. Moreover, cold plasma treatment was employed to immobilize the oxygen scavenger agent (ascorbic acid), chosen for the activation of the packaging material. Preliminary studies on activated PLA pouches filled with sunflower oil, used as model system, were performed. Model systems were stored at 35 °C to accelerate oil oxidation phenomenon and analysed for PV and colour during 64 days of storage. After that, different samples of “Genovese pesto”, were tested as real food, stored at 25 and 45 °C and analysed for PV, water activity, rheological parameters and microbiological loads during 41 days of storage. Obtained results showed the greater ability of the new active packaging to decrease the oxidation kinetics of “pesto”, mainly when stored at 25 °C. Moreover, all samples packed in the activated biodegradable pouches (both sunflower oils stored at 35 °C and pesto stored at 25 °C) showed better and more stable quality characteristics, in terms of colorimetric, microbiological and textural parameters when compared with the respective control samples. Overall obtained results highlighted the potentiality of the new biodegradable material, activated with the oxygen scavenger, to be applied successfully in food industry, to extend food products shelf-life and/or maintain high quality levels during storage.

Finite Reservoirs Corrections to Hamiltonian Systems Statistics and Time Symmetry Breaking

We consider several Hamiltonian systems perturbed by external agents that preserve their Hamiltonian structure. We investigate the corrections to the canonical statistics resulting from coupling such systems with possibly large but finite reservoirs and from the onset of processes breaking the time-reversal symmetry. We analyze exactly solvable oscillator systems and perform simulations of relatively more complex ones. This indicates that the standard statistical mechanical formalism needs to be adjusted in the ever more investigated nano-scale science and technology. In particular, the hypothesis that heat reservoirs be considered infinite and be described by the classical ensembles is found to be critical when exponential quantities are considered since the large size limit may not coincide with the infinite size canonical result. Furthermore, process-dependent emergent irreversibility affects ensemble averages, effectively frustrating, on a statistical level, the time reversal invariance of Hamiltonian dynamics that are used to obtain numerous results.

The agency of community groups in health and climate change adaptation governance and policy in SIDS: The case of in Toco, Trinidad and Tobago

Important development partners encouraged and supported the development of Caribbean islands’ recent action plans and targets on climate change and health. These developments are part of larger global trends around mainstreaming climate change adaptation into national health policy. Including community voices is crucial, yet the responsiveness of regional and national processes around climate change adaptation and health governance to local community concerns is poorly understood. This case study in rural Trinidad and Tobago sought to contribute to better understanding community led action on health and climate change adaptation by investigating community groups’ perceptions of the challenges faced and addressed by their community. The study contributes to climate change adaptation and health debates in three main ways. First, it develops a conceptual framework around agency in the context of health and climate change adaptation in community groups and local spaces. Second, it fills a gap in the literature by registering the voices and perspectives of coastal community groups regarding their development priorities in the context of climate change adaptation and health. Third, using the lens of agency, it highlights the disconnect between local voices and the urgency around the mainstreaming of climate change adaptation and health into regional and national climate change adaptation policies. This study contributes to wider debates around the power of external agents to shape local discourses and policy. The results contrast dominant global narratives underlying recent regional and national policies and suggest that this area is still one where there may be a disconnect between local development priorities and international policy.

Determinants and mechanisms of inorganic nanoparticle translocation across mammalian biological barriers.

Biological barriers protect delicate internal tissues from exposures to and interactions with hazardous materials. Primary anatomical barriers prevent external agents from reaching systemic circulation and include the pulmonary, gastrointestinal, and dermal barriers. Secondary barriers include the blood-brain, blood-testis, and placental barriers. The tissues protected by secondary barriers are particularly sensitive to agents in systemic circulation. Neurons of the brain cannot regenerate and therefore must have limited interaction with cytotoxic agents. In the testis, the delicate process of spermatogenesis requires a specific milieu distinct from the blood. The placenta protects the developing fetus from compounds in the maternal circulation that would impair limb or organ development. Many biological barriers are semi-permeable, allowing only materials or chemicals, with a specific set of properties, that easily pass through or between cells. Nanoparticles (particles less than 100nm) have recently drawn specific concern due to the possibility of biological barrier translocation and contact with distal tissues. Current evidence suggests that nanoparticles translocate across both primary and secondary barriers. It is known that the physicochemical properties of nanoparticles can affect biological interactions, and it has been shown that nanoparticles can breach primary and some secondary barriers. However, the mechanism by which nanoparticles cross biological barriers has yet to be determined. Therefore, the purpose of this review is to summarize how different nanoparticle physicochemical properties interact with biological barriers and barrier products to govern translocation.

Fabrication of the hyper-crosslinked polymers chemically functionalized by 8-hydroxyquinoline and their efficient adsorptive removal of 2-naphthol from water

Hyper-crosslinked polymers (HCPs) chemically functionalized with plentiful heteroatoms are of great importance for the adsorptive removal of polar aromatic substances from water, while their facile fabrication is of great challenge, and the adsorptive removal of the 2-naphthol from water remains a bottleneck. Herein, 8-hydroxyquinoline (HQ) was employed as the chemical modifier and firstly uploaded on the polymers according to the nucleophilic substitution, thereafter several external crosslinking agents were employed and the Friedel-Crafts alkylation was performed for the intermediate polymer, and hence the HCPs chemically functionalized by HQ, namely, PS-HQ-HCPs, were successfully fabricated. The nucleophilic substitution supplied the intermediate polymer with plentiful ether oxygen (O, 4.81%) and pyridine nitrogen (N, 6.39%). The Friedel-Crafts alkylation constructed predominant micro-porosity and meso-porosity for the final polymers with high Brunauer-Emmett-Teller (BET) surface area (SBET, 384–618 m2/g) and pore volume (Vtotal, 0.36–0.63 cm3/g). 2-Naphthol was utilized as the adsorbate to investigate the batch adsorption, and the predicted maximum capacity (qmax) on the final polymer, namely, PS-HQ-DCX was 828 mg/g at 318 K, higher than most synthetic materials. Meanwhile, the adsorption attained the equilibrium within 360 min, and the kinetic data can be described by the micro-pore diffusion model. As the initial 39.5 mg/L of 2-naphthol was fed for the adsorption, the final concentration reduced to 1.9 mg/L, less than the discharge standard in China (GB 8978–19962, mg/L). The dynamic adsorption revealed that the saturated capacity was 632 mg/g, approaching to the fitted qmax (688 mg/g) by the Langmuir model, and 232 mL anhydrous ethanol completely desorbed 2-naphthol from the polymers. This universal synthetic protocol is of great importance for the fabrication of some other functionalized HCPs, and this strategy was universal for some other phenolic compounds and external cross-linking agents.

Selective control of donor-acceptor Stenhouse adduct populations with non-selective stimuli

Selective control of donor-acceptor Stenhouse adduct populations with non-selective stimuli

A multifunctional hybrid extrinsic–intrinsic self-healing laminated composites

Damage healing in fiber reinforced thermoset polymer composites has been generally divided into intrinsic healing by the polymer itself and extrinsic healing by incorporation of external healing agent. In this study, we propose to use a hybrid extrinsic-intrinsic self-healing strategy to heal delamination in laminated composite induced by low velocity impact. Especially, we propose to use an intrinsic self-healing thermoset vitrimer as an external healing agent, to heal delamination in laminated thermoset polymer composites. To this purpose, we designed and synthesized a new vitrimer, machined it into powders, and strategically sprayed a layer of vitrimer powders at the interface between the laminas during manufacturing. Also, a thermoset shape memory polymer with fire-proof property was used as the matrix. As a result, incorporation of about 3% by volume of vitrimer powders made the laminate exhibit multifunctionalities such as repeated delamination healing, excellent shape memory effect, improved toughness and impact tolerance, and decent fire-proof properties. In particular, the novel vitrimer powder imparted the laminate with first cycle and second cycle delamination healing efficiencies of 98.06% and 85.93%, respectively. The laminate also exhibited high recovery stress of 65.6 MPa. This multifunctional composite laminate has a great potential in various engineering applications, for example, actuators, robotics, deployable structures, and smart fire-proof structures.

Management of Trauma of the Male External Genitalia: A Case Report from the Markala Reference Health Center

Trauma of the external genitalia is defined as a set of local lesions, involving tissues and organs, caused by an external agent following various mechanisms. The objective of our work was to write the management of two cases of trauma of the external genitalia at the Csréf of Markala.

Cell disruption and permeabilization methods for obtaining yeast bioproducts

Yeasts are used to produce several bioproducts, including functional bio-molecules, enzymes, biofuels, lipids, pigments, vitamins, organic acids, and other value-added bioproducts. When the production of the bioproduct occurs intracellularly, methods of disruption are traditionally used (mechanical and non-mechanical), which promote the release of bioproducts, but also the total degradation of the cell wall with consequent loss of yeast viability. As an alternative, cell permeabilization methods can be used through the use of external agents (chemical or physical), which form pores that increase the transfer of the product through the membrane, facilitating the separation of material, increasing the production of metabolites and also acting as an effective way of maintaining cellular viability - at least partially. In this review, we summarize the advances in yeast cell wall permeabilization compared to traditional methods of cell rupture. We also present the methods available for evaluating cell disruption and yeast permeabilization for yeast.

Concrete Bridge Deck Reinforced with Textured and Nontextured Epoxy-Coated Bars

The deterioration of bridge decks is a problem typically associated with the corrosion of reinforcing steel bars. This issue is partially controlled with the incorporation of epoxy-coating protection on the bars. However, later research demonstrated that the smooth surface resulting from the epoxy-coating application reduces most of the friction between the deformed rebars (with a manufactured pattern of surface ridges) and the surrounding concrete. Consequently, forces acting on the ribs of the rebars are reconfigured such that the radial components increase, triggering the early development of cracks. To mitigate both the reduction of bonding and the formation of cracks, the Illinois Department of Transportation proposed a new type of coated bars: textured epoxy-coated (TEC) bars. This study is a continuation of the research efforts aimed to evaluate the bond behavior of TEC rebars. The experimental program aims to explore and compare the impact of drying shrinkage, thermal, and flexural demands on the performance of two large-scale bridge deck specimens reinforced, individually, with TEC and standard epoxy-coated (EC) bars. The data collected from both specimens using digital image correlation and strain gauges make it possible to interpret the spatial distribution of strain during the performance of different tests. Precisely, from the shrinkage test, the results suggest that TEC rebars more actively resist the stress induced by the shrinking action. Regarding the thermal effect test, more but finer cracks develop in the specimen that incorporated the TEC bars. This observation implies an overall reduction of the reinforcement exposure to external agents. Ultimately, the results of the flexural test demonstrate that the TEC bars possess a higher resistance to slip and crack widening. The EC specimen, in contrast, demonstrates a lower stiffness under flexural demands, which can be related to the inferior engagement of the rebars to the concrete matrix.

Factors influencing decisions people with motor neuron disease make about gastrostomy placement and ventilation: A qualitative evidence synthesis.

People with motor neuron disease (pwMND) are routinelyoffered gastrostomy feeding tube placement and (non-invasive and invasive) ventilation to manage the functional decline associated with the disease. This study aimed to synthesise the findings from the qualitative literature to understand how individual, clinical team and organisational factors influence pwMND decisions about these interventions. The study design was guided by the enhancing transparency in reporting the synthesis of qualitative research (ENTREC) statement. The search of five bibliography databases and an extensive supplementary search strategy identified 27 papers that included qualitative accounts of pwMND, caregivers and healthcare professionals' (HCPs) experiences of making decisions about gastrostomy and ventilation. The findings from each study were included in a thematic synthesis. Making decisions about interventions is an emotional rather than simply a functional issue for pwMND. The interventions can signal an end to normality, and increasing dependence, where pwMND consider the balance between quality of life and extending survival. Interactions with multiple HCPs and caregivers can influence the process of decision-making and the decisions made. These interactions contribute to the autonomy pwMND are able to exert during decision-making. HCPs can both promote and threaten pwMND perceived agency over decisions through how they approach discussions about these interventions. Though there is uncertainty over the timing of interventions, pwMND who agree to interventions report reaching a tipping point where they accept the need for change. Discussion of gastrostomy and ventilation options generate an emotional response in pwMND. Decisions are the consequence of interactions with multiple external agents, including HCPs treading a complex ethical path when trying to improve health outcomes while respecting pwMND right to autonomy. Future decision support interventions that address the emotional response and seek to support autonomy have the potential to enable pwMND to make informed and timely decisions about gastrostomy placement and ventilation. The lead author collaborated with several patient and participant involvement (PPI) groups with regards to the conceptualisation and design of this project. Decisions that have been influenced by discussions with multiple PPI panels include widening the scope of decisions about ventilation in addition to gastrostomy placement and the perceptions of all stakeholders involved (i.e., pwMND, caregivers and HCPs).

Designing antimicrobial biomembranes via clustering amino-modified cellulose nanocrystals on silk fibroin β-sheets

The continuous rising of infections caused by multidrug-resistant pathogens is becoming a global healthcare concern. Developing new bio-based materials with unique chemical and structural features that allow efficient interaction with bacteria is thus important for fighting this phenomenon. To address this issue, we report an antimicrobial biomaterial that results from clustering local facial amphiphilicity from amino-modified cellulose on silk fibroin β-sheets, by simply blending the two components through casting technology. A simple but effective method for creating a membrane that is antibacterial and non-cytotoxic. Amino-modified cellulose nanocrystals (CNC-NH2) were mixed with proteinaceous silk fibroin (SF) which resulted in a material with improved crystallinity, higher β-sheet content, and exposed amino-groups at its surface features, proven by Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS), that does not occur when the components are individually assembled. The resulting material possesses important antibacterial activity inducing >3 CFU log10 reduction of Escherichia coli and Staphylococcus epidermidis, while the pristine membranes show no antibacterial effect. The chemical interactions occurring between SF and CNC-NH2 during casting, exposing the amino moieties at the surface of the material, are proposed as the main reason for this antimicrobial activity. Importantly, the membranes are non-cytotoxic, showing their potential to be used as a new bioinspired material with intrinsic antibacterial activity for biomedical applications. Those may include coatings for medical devices for the control of healthcare-associated infections, with no need for including external antimicrobial agents in the material.