Climate change-driven sea level rise has intensified salinity intrusion (SI) in deltas worldwide, posing significant threats to the exploitation of freshwater resources. In the Vietnamese Mekong Delta (VMD), the third largest delta globally, SI is a recurring challenge along the coastline, degrading freshwater resources for agricultural and domestic use and affecting socio-economic development. In this paper, we investigate the spatiotemporal extent of salinity intrusion in the Ben Tre Province, the hotspot of salinity disaster within the VMD. Long-term salinity monitoring data (25 years from 1996 to 2020) has been analyzed, and a 1D (Mike 11) coupled with 3D hydrodynamic model (Mike 3) was developed. Three scenarios were used to investigate the freshwater resources exploitation: (i) the year of investigation (2021), (ii) 2021 to 2030 climate change impacts, considering different annual exceedance probability of the upstream Mekong discharge (i.e., average flow, relatively low, low and very low), and (iii) extreme salinity intrusion (i.e., the 2016 condition). Our results indicated that salinity patterns are well-stratified at the beginning and end of the dry season but well-mixed during the middle period. Furthermore, over the last 25 years, SI has progressively increased and started earlier in the dry season. The modeling scenarios for SI have also revealed a growing complexity in the exploitation of freshwater resources, highlighting challenges related to timing, depth, and geographical location. The exceedance probability scenarios disclosed higher and deeper salinity intrusion along the channel in VMD, ranging from 50 % to 95 %. This poses significant limitations on the feasibility of freshwater exploitation throughout the Ben Tre Province. Under the current trajectory of climate change, the 2030 scenario anticipates salinity intrusion reaching further inland from the 2021 scenario. This is likely to exacerbate the existing challenges in freshwater resource exploitation, even with comprehensive water infrastructure. We, therefore, propose several management strategies to adapt to salinity intrusion: storing freshwater in main rivers, maintaining consistent operation of water infrastructure systems, and encouraging water-saving distribution and exploitation methods. Moreover, we also recommend supporting the development of new drought-tolerant crop patterns.