Extent In Men Research Articles

A dynamic landscape of allergen associations in delayed-type cutaneous hypersensitivity.

Delayed-type hypersensitivity represents a significant clinical and public health challenge. Patients undergoing patch testing may exhibit positive reactions to more than one allergen. It is recognized that reactions to specific pairs of allergens are associated, reflecting a combination of exposure patterns and structural similarity. To explore the influence of time of testing, age, sex and atopy status on allergen pair associations in a series of 45 110 consecutive patients tested over 30 years. Patch test records of all patients undergoing testing with a modified European baseline series between 1985 and 2014 were retrieved from a database at St John's Institute of Dermatology. Reactions were read on days 2 and 4. For each allergen it was recorded whether the allergen was tested and whether the result was positive or negative. This is the largest reported study of patch test allergen pair relationships. Our analysis shows a high degree of variability in allergen pair associations. Rigorous statistical analysis reveals a large number of differences between groups, including a significant increase in the association between formaldehyde and multiple formaldehyde-releasing preservatives over the study period, in addition to pair associations with cobalt and formaldehyde-releasing preservatives. These were present to a significantly greater extent in men than in women. These observations extend our understanding of cutaneous allergy, with implications for both clinical practice and mechanisms of cutaneous hypersensitivity.

Sex-based difference in Achilles peritendinous levels of matrix metalloproteinases and growth factors after acute resistance exercise.

Several recent investigations have demonstrated that the ability of various tendons to alter structural and functional properties in response to exercise are muted in women compared with men. We hypothesize that this disparity between men and women may be due to a reduced tendon production of key mediators of tendon extracellular matrix (ECM) remodeling in response to mechanical loading, e.g., exercise. Using microdialysis before and after an acute bout of resistance exercise, we evaluated Achilles peritendinous levels of insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6), which have both been shown to increase tendon collagen synthesis. Additionally, the matrix remodeling enzymes matrix metalloproteinase-2 (MMP-2), MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1) were also evaluated. IGF-1 levels were elevated (P < 0.05) to a similar extent in men and women after 3 h of exercise but remained elevated at 4 h in only women. IL-6 levels were ~4-fold greater after exercise in both men and women (P < 0.05). MMP-2 levels increased to a similar extent (~2-3-fold) in men and women (P < 0.05). In contrast, MMP-9 increased with exercise but only in men (P < 0.05). Last, TIMP-1 levels also increased (P < 0.05) with exercise in men and women but the increase was more prolonged in women. In conclusion, we observed modest sex differences in tendon release of MMP-9, TIMP-1, and IGF-1 after acute resistance exercise. If such differences persist throughout a chronic exercise training, they may contribute to the reduced ability of women to adapt to exercise compared with men.NEW & NOTEWORTHY In this investigation we utilized microdialysis of the peritendinous Achilles to evaluate potential differences between men and women in tendon production of key regulators of extracellular matrix remodeling. We demonstrate that a modest sex-specific difference exists in peritendinous levels of several key extracellular matrix modulators after an acute bout of resistance exercise.

Altered states of consciousness are related to higher sexual responsiveness.

Altered states of consciousness lead to profound changes in the sense of self, time and space. We assessed how these changes were related to sexual responsiveness during sex. 116 subjects reported (a) intensity of awareness concerning body, space and time, and (b) satisfaction, desire, arousal, and orgasm occurrence. We differentiated vaginal intercourse orgasm from noncoital orgasm. Female vaginal intercourse orgasm was further differentiated as with or without concurrent clitoral masturbation. Overall, sexual responsiveness was related to greater body awareness and lesser time and space awareness. Satisfaction, desire, and arousal were especially associated with less time awareness in women. Female orgasms during vaginal intercourse were related to greater body awareness and lesser time awareness, but noncoital orgasms were unrelated. Our findings provide empirical support for the hypotheses that altered states of consciousness with attentional absorption are strongly related to sexual responsiveness in women, and to a lesser extent in men.

Gender, education, and family life courses in East and West Germany: Insights from new sequence analysis techniques

Abstract How do men and women's family life courses differ? Are gender differences in family life courses greater at higher or lower educational levels? And how does the intersection of gender, education and family life courses vary across different macro-structural contexts? This paper addresses these questions comparing East and West Germany during the German division (1961–1990). We thereby compare a strong male breadwinner model in a social market economy in West Germany and a universal breadwinner model in a state socialist system in the East. The analysis uses data from the German National Education Panel (NEPS) and employs two new sequence analysis tools: sequence discrepancy analysis and the implicative statistic for analyzing sequences of typical states. These tools enable us to scrutinize the degree, content, and timing of differences in family trajectories between men and women of different educational levels in the two sub-societies. In line with our expectations, family life courses were more de-standardized in the West compared to the East, and this occurred to the same extent for men and women in both contexts. While we find moderate gender differences in family life courses across all educational groups in the strong male breadwinner context in West Germany, for East Germany gender differences were significant among the medium and lower educated, but not among the highly educated. These findings underline the fact that the intersection of gender and education for family life courses is highly context-specific. They further suggest that different patterns of assortative mating play a key role for gender differences in family life courses. We demonstrate the added value of sequence discrepancy analysis and the implicative statistic to illuminate differences in longitudinal life courses between men and women or other social groups.

Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment

GH and IGF-I have important roles in the maintenance of substrate metabolism and body composition. However, when in excess in acromegaly, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) deposition. The purpose of this study was to examine the effect of surgery for acromegaly on AT distribution and ectopic lipid deposition in liver and muscle. This was a prospective study before and up to 2 years after pituitary surgery. The setting was an academic pituitary center. Participants were 23 patients with newly diagnosed, untreated acromegaly. We determined visceral (VAT), subcutaneous (SAT), and intermuscular adipose tissue (IMAT), and skeletal muscle compartments by total-body magnetic resonance imaging, intrahepatic and intramyocellular lipid by proton magnetic resonance spectroscopy, and serum endocrine, metabolic, and cardiovascular risk markers. VAT and SAT masses were lower than predicted in active acromegaly, but increased after surgery in male and female subjects along with lowering of GH, IGF-I, and insulin resistance. VAT and SAT increased to a greater extent in men than in women. Skeletal muscle mass decreased in men. IMAT was higher in active acromegaly and decreased in women after surgery. Intrahepatic lipid increased, but intramyocellular lipid did not change after surgery. Acromegaly may present a unique type of lipodystrophy characterized by reduced storage of AT in central depots and a shift of excess lipid to IMAT. After surgery, this pattern partially reverses, but differentially in men and women. These findings have implications for understanding the role of GH in body composition and metabolic risk in acromegaly and other clinical settings of GH use.

Gender-specific modulation of neural mechanisms underlying social reward processing by Autism Quotient.

Autism spectrum disorder refers to a neurodevelopmental condition primarily characterized by deficits in social cognition and behavior. Subclinically, autistic features are supposed to be present in healthy humans and can be quantified using the Autism Quotient (AQ). Here, we investigated a potential relationship between AQ and neural correlates of social and monetary reward processing, using functional magnetic resonance imaging in young, healthy participants. In an incentive delay task with either monetary or social reward, reward anticipation elicited increased ventral striatal activation, which was more pronounced during monetary reward anticipation. Anticipation of social reward elicited activation in the default mode network (DMN), a network previously implicated in social processing. Social reward feedback was associated with bilateral amygdala and fusiform face area activation. The relationship between AQ and neural correlates of social reward processing varied in a gender-dependent manner. In women and, to a lesser extent in men, higher AQ was associated with increased posterior DMN activation during social reward anticipation. During feedback, we observed a negative correlation of AQ and right amygdala activation in men only. Our results suggest that social reward processing might constitute an endophenotype for autism-related traits in healthy humans that manifests in a gender-specific way.

Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial

Muscle weakness and fatigue are common symptoms in multiple sclerosis (MS). Green tea catechins such as (-)epigallocatechin-3-gallate (EGCG) are known to improve energy metabolism at rest and during exercise. We tested the hypothesis that EGCG improves energy metabolism and substrate utilization in patients with MS. Eighteen patients (8 men) with relapsing-remitting MS (expanded disability status scale score <4.5, all receiving glatiramer acetate) participated in this randomized, double-blind, placebo-controlled, crossover trial at a clinical research center. All patients received EGCG (600 mg/d) and placebo over 12 wk (4-wk washout in between). After each intervention, fasting and postprandial energy expenditure (EE), as well as fat oxidation (FAOx) and carbohydrate oxidation (CHOx) rates, were measured either at rest or during 40 min of exercise (0.5 W/kg). At rest, blood samples and microdialysates from adipose tissue and skeletal muscle were also taken. At rest, postprandial EE and CHOx, as well as adipose tissue perfusion and glucose supply, were significantly lower in men but higher in women receiving EGCG compared with placebo. During exercise, postprandial EE was lower after EGCG than after placebo, indicating an increased working efficiency (men > women). After placebo, exercise EE was mainly fueled by FAOx in both men and women. After EGCG, there was a shift to a higher and more stable CHOx during exercise in men but not in women. Our data indicate that EGCG given to patients with MS over 12 wk improves muscle metabolism during moderate exercise to a greater extent in men than in women, possibly because of sex-specific effects on autonomic and endocrine control.

Sex and Acetazolamide Effects on Chemoreflex and Periodic Breathing During Sleep at Altitude

Nocturnal periodic breathing occurs more frequently in men than in women with various clinical and pathophysiologic conditions. The mechanisms accounting for this sex-related difference are not completely understood. Acetazolamide effectively counteracts nocturnal periodic breathing, but it has been investigated almost exclusively in men. Our aim was to explore possible determinants of nocturnal periodic breathing in a high-altitude setting both in men and in women. We hypothesized that increased hypoxic chemosensitivity in men could be associated with the development of nocturnal periodic breathing at altitude more frequently than in women, and that acetazolamide, by leftward shifting the CO2 ventilatory response, could improve nocturnal periodic breathing at altitude in a sex-independent manner. Forty-four healthy lowlanders (21 women), randomized to acetazolamide or placebo, underwent cardiorespiratory sleep studies at sea level off treatment and under treatment on the first night after arrival at a 4,559-m altitude. Hypoxic and hypercapnic chemosensitivities were assessed at sea level. Men, more frequently than women, exhibited increased hypoxic chemosensitivity and displayed nocturnal periodic breathing at altitude. Acetazolamide leftward shifted the CO2 set point and, at altitude, improved oxygenation and reduced periodic breathing in both sexes, but to a larger extent in men. Hypoxic chemosensitivity directly correlated with the number of apneas/hypopneas at altitude in the placebo group but not in the acetazolamide group. The greater severity of periodic breathing during sleep displayed by men at altitude could be attributed to their increased hypoxic chemosensitivity. Acetazolamide counteracted the occurrence of periodic breathing at altitude in both sexes, modifying the apneic threshold and improving oxygenation. EU Clinical Trials Register, EudraCT; No.: 2010-019986-27; URL: https://www.clinicaltrialsregister.eu.

Sex affects vascular responses to acute inflammation in older adults (852.2)

Aging results in increased arterial stiffness and blood pressure (BP) in both sexes and is associated with chronic, low‐grade inflammation that appears to affect cardiovascular function to a greater extent in men versus women. Acute inflammation, found during co‐morbidities common in aging, also disrupts cardiovascular homeostasis. Our purpose was to determine whether sex affects vascular responses to acute inflammation in older adults. Inflammation was induced in 25 healthy older adults (m=9, f=16) with an influenza vaccine. Central BP, augmentation index controlled for heart rate (AIx@75), serum C‐reactive protein (CRP), and central pulse wave velocity (cPWV) were measured before and 24 and 48hr post‐vaccination. Post‐vaccination, the cohort increased CRP and reduced cMAP (from90±2 to 86±2 to 87±2 mmHg; p&lt;0.05). Men maintained while women decreased AIx@75 (from 20±3 to 24±5 to 25±2% in men and from 32±2 to 31±1 28±2% in women; p&lt;0.05 for interaction) and the interaction for cPWV controlled for MAP, (from 0.08±0.008 to 0.10±0.006 to 0.09±0.004 in men and from 0.08±0.005 to 0.08±0.006 to 0.09±0.007 m/s/mmHg in women) approached significance, p=0.057. These data indicate that there are sex differences in arterial responses to acute inflammation, and this may result in differing risks for cardiac events during acute inflammation between sexes.

Physiological stress responses and horse rider interactions in horses ridden by male and female riders

Traditionally, horse riding has been restricted to men but today equestrian sports are dominated by women. We hypothesised that men and women differ with regard to riding and the response they evoke in their horse. Cortisol and heart rate variability (HRV) were studied in male (n=8) and female riders (n=8) and in horses (n=8) ridden by men and women over a jumping course. Saliva for cortisol analysis was collected, cardiac beat to beat (RR) intervals were recorded and heart rate and HRV variables SDRR (standard deviation of RR interval) and RMSSD (root mean square of successive RR differences) calculated. In another experiment, saddle pressure was compared between male and female riders (n=5 each). Cortisol did not differ between male and female riders and increased in horses (P&lt;0.001) irrespective of the sex of the rider. Heart rate in riders increased from walk to jumping (P&lt;0.001) while HRV decreased (P&lt;0.001) to the same extent in men and women. In horses, heart rate increased (P&lt;0.001) and SDRR and RMSSD decreased during walk and remained low at trot and canter (P&lt;0.001) irrespective of the riders’ sex. In trot (P&lt;0.05) and canter (P&lt;0.01) saddle pressure was slightly lower in female versus male riders. This is due to weight differences and not to a different seat. In conclusion, no fundamental differences existed in the physical effort, stress response and seat between male and female riders and in the response of horses to men and women.

Sex Differences in the Effects of Mental Work and Moderate-Intensity Physical Activity on Energy Intake in Young Adults

The aim of this study was to examine the acute effects of mental work and moderate-intensity physical activity on various components of energy balance in young and healthy adults. With the use of a randomized crossover design, 35 participants aged 24 ± 3 years completed three 45-min conditions, namely, (i) resting in a sitting position (control), (ii) reading and writing (mental work (MW)), and (iii) exercising on a treadmill at 40% of peak oxygen uptake (exercise), followed by an ad libitum lunch. The endpoints were spontaneous energy intake (EI), energy expenditure (EE), appetite sensations, and EI for the remainder of the day. We observed that the energy cost of the control and MW conditions was about the same whereas the exercise condition increased EE to a greater extent in men than women. Exercise induced a decrease in EI relative to EE compared to the control condition that was more pronounced in men than women. However, women tended to increase their energy intake after the MW condition compared to the control one whereas an opposite trend was observed in men. None of the appetite sensation markers differed significantly between both sexes. In conclusion, men and women have specific food intake patterns when submitted to cognitive and physical stimuli.

Gender Differences in Trauma and Posttraumatic Stress Symptoms among Displaced Zimbabweans in South Africa.

Over the years, more than 3.4 million Zimbabweans (a quarter of the country's population) have fled the country to other countries with South Africa as the main popular destination. In South Africa, they become a vulnerable group with the plausibility of suffering trauma and PTSS or PTSD due to xenophobic attacks and resentment. How males and females are impacted is undocumented in psychological literature, particularly with regards to Africa. In addition, global research on gender differences, trauma and PTSS/PTSD are inconclusive. This paper explores gender differences in PTSS among displaced Zimbabweans in South Africa. A poor mental health status, pre and post-migration traumas of men and women were hypothesized to have a relationship with PTSS for women, but not to the same extent for men. Through a guided purposive convenient sampling, in-depth interviews using questionnaires, data were obtained from a sample of 125 displaced and homeless Zimbabwean refugees in Polokwane, Limpopo Province, South Africa. Participants were assessed on demographic variables, pre- and post-migration difficulties checklists, mental health using the General Health Questionnaire (GHQ-28) and the PTSD Checklist (Civilian Version (PCL). The hypothesis of a gender difference in the predictability of PTSD was tested in structural equation models. For men none of the three paths (pre-migration stress, post-migration stress, and poor mental health) on PTSD is significant, whereas for women both the path from poor mental health onto PTSD (ß=.36, p=.013) are significant, but the size of the gender differences was modest. However, effect sizes are always larger for women than they are for men. The findings help closing the gap in PTSS/PTSD research for Africans and suggest that indeed likely gender differences in the prediction of PTSS, suggested in the literature, needs further attention.

Effect of spironolactone in patients with resistant arterial hypertension in relation to age and sex: Insights from the aspirant trial

There are currently limited data on whether the effect of spironolactone in patients with resistant arterial hypertension depends on age and sex. Patients with an office systolic blood pressure (BP)>140 mmHg or diastolic BP>90 mmHg, despite treatment with at least 3 antihypertensive drugs including a diuretic, were randomly assigned to receive spironolactone or a placebo for 8 weeks in a double-blind, placebo-controlled, multicentre trial (ASPIRANT). Analyses were done on 55 patients treated with spironolactone and 56 patients treated with placebo. Significant reductions of office systolic BP (-8.9±6.7 mmHg, P=0.012), 24-h ABPM systolic BP (-7.9±7.2 mmHg, P=0.032) and ABPM day-time systolic BP (-7.5±7.1 mmHg) after 8 weeks of spironolactone treatment, compared to placebo, were only observed in patients with a median age>62 years. The office and ABPM systolic BP reductions in patients aged ≤62 years and diastolic BP reductions by spironolactone in both age groups were not significant compared to placebo. Women tended to have a nonsignificantly higher reduction in systolic BP with spironolactone treatment, and there was no difference in diastolic BP reduction between women and men. Spironolactone only leads to a reduction of systolic BP in older patients with resistant arterial hypertension aged >62 years, and is effective to a similar extent in men and women.

Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state

We made sex-based comparisons of rates of myofibrillar protein synthesis (MPS) and anabolic signaling after a single bout of high-intensity resistance exercise. Eight men (20 ± 10 yr, BMI = 24.3 ± 2.4) and eight women (22 ± 1.8 yr, BMI = 23.0 ± 1.9) underwent primed constant infusions of l-[ring-(13)C(6)]phenylalanine on consecutive days with serial muscle biopsies. Biopsies were taken from the vastus lateralis at rest and 1, 3, 5, 24, 26, and 28 h after exercise. Twenty-five grams of whey protein was ingested immediately and 26 h after exercise. We also measured exercise-induced serum testosterone because it is purported to contribute to increases in myofibrillar protein synthesis (MPS) postexercise and its absence has been hypothesized to attenuate adaptative responses to resistance exercise in women. The exercise-induced area under the testosterone curve was 45-fold greater in men than women in the early (1 h) recovery period following exercise (P < 0.001). MPS was elevated similarly in men and women (2.3- and 2.7-fold, respectively) 1-5 h postexercise and after protein ingestion following 24 h recovery. Phosphorylation of mTOR(Ser2448) was elevated to a greater extent in men than women acutely after exercise (P = 0.003), whereas increased phosphorylation of p70S6K1(Thr389) was not different between sexes. Androgen receptor content was greater in men (main effect for sex, P = 0.049). Atrogin-1 mRNA abundance was decreased after 5 h recovery in both men and women (P < 0.001), and MuRF-1 expression was elevated in men after protein ingestion following 24 h recovery (P = 0.003). These results demonstrate minor sex-based differences in signaling responses and no difference in the MPS response to resistance exercise in the fed state. Interestingly, our data demonstrate that exercise-induced increases in MPS are dissociated from postexercise testosteronemia and that stimulation of MPS occurs effectively with low systemic testosterone concentrations in women.

RECREATING IGNORANCE?

In 2001, the first major study of the extent of men's violence against women in Sweden reported that almost every other woman had been exposed to male violence. This article investigates how this feminist-based survey was negotiated by the press and in national politics. The legitimacy of the investigation was undermined in a number of ways, both in the media and in politics. The report was defined as partial and not as reliable as ‘conventional’ criminological research. The resistance provoked by the investigation is here interpreted as a way of producing nationalistic notions, where ‘Swedishness’ is recreated as being woman-friendly, just and equal.

Relative changes in resting energy expenditure during weight loss: a systematic review

A more comprehensive understanding of the effects of weight loss on the changes in resting energy expenditure (EE) is relevant. A MEDLINE search was performed to identify studies with information relevant to this systematic review. From this search, the mean rate of resting EE decrease relative to weight loss was calculated from 90 available publications. A decrease of resting EE relative to weight loss of -15.4 +/- 8.7 kcal kg(-1) was observed from 2977 [corrected] subjects. No sex differences were noted in the overall resting EE decrease relative to weight loss. However, a significant sex differences was seen with pharmacological interventions, which seemed to depress the resting EE relative to weight loss to a greater extent in men than in women (P < 0.05). A greater drop in resting EE relative to weight loss was observed for short interventions (more than 2 but less than 6 weeks) when compared with long interventions (<6 weeks) (-27.7 +/- 6.7 vs. -12.8 +/- 7.1 kcal kg(-1)) (P < 0.001). Men and women have a similar decrease in resting EE relative to weight loss except in the case of pharmacological interventions. Short interventions also produced greater resting EE losses relative to weight loss.

Die Herausforderung globaler Klimawandel

At least half of the global warming observed during the 20th century of about 0.8°C is of anthropogenic origin and mostly due to enhanced atmospheric carbon dioxide levels in response to the burning of fossil fuels. The climate problem is therefore closely linked to the way we produce energy. Climate models predict a massive warming by the end of the century should global greenhouse gas emissions not be strongly reduced. The Intergovernmental Panel on Climate Change (IPCC) reports that the warming can amount to up to 4°C in a worst case scenario, which would be unprecedented in speed and extent in man's history. This can lead to an increase of extreme weather events and a rise of global sea level by up to 1m. A less known impact of increasing atmospheric carbon dioxide is ocean acidification, as the oceans take up large amounts of carbon dioxide. Ocean acidification potentially threatens marine life and global food production.

Zinc supplementation prevents increases in prevalence of hypertension among HIV infected adults in Miami

ObjectiveHIV is a risk factor for hypertension (HTN). This study examines the prevalence of HTN in a clinical trial of HIV+ adults receiving zinc (12 mg for women and 15 mg for men) or placebo over 18 months.MethodsAfter consenting 231 HIV+ adults, physical examinations were done. HTN was defined as having diagnosed HTN, blood pressure &gt;140/90 or receiving treatment for HTN at baseline, 6, 12, and 18 months. Descriptive statistics, ANOVA (controlled for age and ART), and Post‐Hoc tests were performed.ResultsMean age was 42.7±7.0 years. The prevalence of HTN was 48.9% (n=113; 82 women, 31 men), significantly increasing over 18 months by 12±3.2%. There were significant interactions between time, treatment and gender in modifying HTN (p=0.015). When compared to women supplemented with zinc, women on placebo had a significant and sustained increase in the prevalence of HTN (5.1% vs. 3.28%, p=0.016) by 18 months. Men on placebo, as compared to those on zinc, had significant increase in prevalence of HTN at 6 months (14.8 vs. 1.9%, p=0.037) with no differences afterwards.ConclusionsThe prevalence of HTN among HIV+ adults in Miami is almost twice that of the general population (48.9% vs. 25.5%) of similar age. Zinc supplementation compared to placebo, prevented increases in HTN in women and to a lesser extent in men. Further studies are needed to elucidate the mechanisms for zinc action on HTN.Supported by NIDA

Medullary thyroid carcinoma and biomarkers: past, present and future

The clinical management of patients with persistent or recurrent medullary thyroid carcinoma (MTC) is still under debate, because these patients either have a long-term survival, due to an indolent course of the disease, or develop rapidly progressing disease leading to death from distant metastases. At this moment, it cannot be predicted what will happen within most individual cases. Biomarkers, indicators which can be measured objectively, can be helpful in MTC diagnosis, molecular imaging and treatment, and/or identification of MTC progression. Several MTC biomarkers are already implemented in the daily management of MTC patients. More research is being aimed at the improvement of molecular imaging techniques and the development of molecular systemic therapies. Recent discoveries, like the prognostic value of plasma calcitonin and carcino-embryonic antigen doubling-time and the presence of somatic RET mutations in MTC tissue, may be useful tools in clinical decision making in the future. In this review, we provide an overview of different MTC biomarkers and their applications in the clinical management of MTC patients.

Sex differences in the effects of aerobic and anaerobic exercise on blood pressure and arterial stiffness

Exercise can be used as an antihypertensive prescription for individuals with pre- to stage-1 essential hypertension, but the outcomes differ between the sexes and depend on the mode of exercise employed. Both aerobic exercise and resistance training lower blood pressure in men and women; however, resistance training lowers diastolic blood pressure to a greater extent in women but increases arterial stiffness to a greater extent in men. These studies emphasize the need for further research on the effect of resistance exercise training on blood pressure and arterial stiffness so that sex differences in response to exercise treatment programs are fully taken into account when devising individual antihypertensive treatment regimens.