The intracontinental response to plate-boundary and mantle processes, such as subduction or continental collisions, is an important topic in the Earth Sciences. Cretaceous to Cenozoic extension across East China is related to the interaction between the Asian continental lithosphere and western Pacific oceanic subduction system, and the associated intra-plate structures and basins provide robust temporal and spatial records of regional continental deformation. Although extension may primarily be driven by slab rollback and/or back-arc opening, mid-ocean-ridge subduction may have played a significant role in this process. To explore how the western Pacific subduction system impacts intracontinental deformation across East China, we use onshore-offshore geological records, geophysical survey observations, and time-dependent Pacific plate models to document the temporal and spatial variation of continental deformation in the Lower Yangtze region adjacent to the Yellow Sea. Based on our compilation, we argue that mantle-wedge convection, with coupled subduction of the trench-parallel Izanagi (Paleo-Pacific)-Pacific mid-ocean ridge, exerts a first-order control on extensional deformation in East China. Beneath eastern China, the mantle wedge history consists of two phases: (1) initial development of the mantle wedge as the Cretaceous Izanagi slab transitioned from flat-slab to steep subduction; and (2) mature mantle wedge convection during Cenozoic subduction of the Pacific plate. Relatively steep subduction of the progressively younging Izanagi plate during the Late Cretaceous-Paleocene resulted in strong mantle convection and coupled upper plate extension in eastern China. The collision of the Izanagi-Pacific plate ridge system with the trench resulted in a magmatic gap and short-lived uplift of eastern China. Following this, subduction of the rapidly aging Pacific plate resulted in a larger, but relatively weaker, mantle convection cell that drove weaker upper plate extension. The vigor of wedge mantle convection was modulated by the age of the Pacific subducting slab, which directly influenced the formation and evolution of intracontinental extension and sedimentary basins across eastern China. The pre-existing Triassic Tan-Lu fault zone has reactivated since the Late Eocene (ca. 40 Ma) due to westward subduction of the Pacific slab to partition strain between extensional dextral faulting in the Bohai Bay and Lower Yangtze basins, thereby diversifying Cenozoic lithospheric extensional deformation in eastern China. Several major Cenozoic extensional basins spatially correlate with the Triassic Sulu orogenic belt, which we interpret to suggest that these basins are underlain by the older and fragmented orogenic basement that acted as mechanically weak zones for localized high-magnitude extension. We present a comprehensive tectonic model that relates intracontinental deformation to subduction zone dynamics, particularly emphasizing the importance of the age of the subducting slab, thus providing a coherent geologic process to explain the deformation kinematics in eastern China and the diversity of observed Mesozoic-Cenozoic basin formation.