You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research (II)1 Apr 20131025 INFLUENCE OF ENDOCRINE DISRUPTORS IN WATER ON ANDROGENITAL SYSTEMS OF RATS Gökhan Hadi Komesli, Haldun Umudum, Okan Tarik Komesli, Celal Ferdi GÖkçay, and Ibrahim Yaþar Özgök Gökhan Hadi KomesliGökhan Hadi Komesli Erzurum , Turkey More articles by this author , Haldun UmudumHaldun Umudum Ankara, Turkey More articles by this author , Okan Tarik KomesliOkan Tarik Komesli Erzurum , Turkey More articles by this author , Celal Ferdi GÖkçayCelal Ferdi GÖkçay Ankara, Turkey More articles by this author , and Ibrahim Yaþar ÖzgökIbrahim Yaþar Özgök Ankara, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.610AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES ED are chemicals that disrupt function of endocrine systems. ED's exist in drinking and waste water. Current study aims to investigate Bisphenol-A, progesterone, estrogen and carbamazapine compounds and their non-biodegraded metabolites on genital systems of male rats. METHODS Current study was financed by “Scientific and technological research council of Turkey-TUBITAK”. Local ethics committee approved the project. Spraque-Dowley rats were utilized in study.. Bisphenol-A, progesterone and estrogen solutions that are equal to their solutions in waste water were prepared in Middle East Technical University, Department of Environmental Engineering. Total 96 rat were assigned into 9 groups (BPA only, EP only, PROG only, combinations and control). ED's have been given in drinking water. Hormone profiles were obtained from venous blood. Rats were sacrified after anesthesia and internal genital organs were dissected. After conventional histopathological assessment, immunohistochemical expression of androgen receptor and GnRH receptor were evaluated. RESULTS Testesteron and free testesteron leves were significantly lower in combination group ( p<0.05, FA). In prog group, testesteron levels were significantly increased (P<0.05). The most prominent difference was that testicular weight were significantly reduced in rats who was fed with combination ED's There were 3 spermatositik arrest in 2 rat. Expression of AR and GnRh aee not different among groups. CONCLUSIONS Prevalence of disease that result in male fertility has been increasing over the last decade. ED's were held responsible for this increase. Current data showed that exposure of mammals to ED' even after birth might affect off*-spring's fertility. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e420 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gökhan Hadi Komesli Erzurum , Turkey More articles by this author Haldun Umudum Ankara, Turkey More articles by this author Okan Tarik Komesli Erzurum , Turkey More articles by this author Celal Ferdi GÖkçay Ankara, Turkey More articles by this author Ibrahim Yaþar Özgök Ankara, Turkey More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...