An important component in chemical risk evaluation is to have a common understanding of how substances are used in occupational settings, including work conditions and exposure controls. Identifying every workplace activity and associated condition would result in a large set of highly specific scenarios, each of limited application. An alternative approach is to more generically group tasks when high throughput exposure estimates are desired and conservative models applied. Exposure potential for workers in these respective activities or process types can be linked to emission profiles based on substance physical chemical properties. For example, products containing a moderate volatility solvent applied by hand brush can be expected to result in like inhalation risk under like use conditions, regardless if the product is a paint, adhesive, or cleaning agent. Amended TSCA defines conditions of use as “the circumstances, as determined by the Administrator, under which a chemical substance is intended, known, or reasonably foreseen to be manufactured, processed, distributed in commerce, used, or disposed of.’’ Similarly under REACH use and conditions of use “means any processing, formulation, consumption, storage, keeping, treatment, filling into containers, transfer from one container to another, mixing, production of an article or any other utilization”. In modernized countries industrial work environments are likely to have similar operations and worker regulatory protections to prevent exposure. Therefore, exposure evaluation approaches and tools applied to assess substance uses for EU REACH may also be helpful to inform risk evaluations under amended TSCA.This presentation overviews REACH use description for worker exposure assessment and fundamental input parameters used to screen occupational exposure risks. Concepts and approach will be highlighted with an example using the ECETOC targeted risk assessment tool.