Abstract This study demonstrates the use of fractional calculus in the field of epidemiology, specifically in relation to dengue illness. Using noninteger order integrals and derivatives, a novel model is created to examine the impact of temperature on the transmission of the vector–host disease, dengue. A comprehensive strategy is proposed and illustrated, drawing inspiration from the first dengue epidemic recorded in 2009 in Cape Verde. The model utilizes a fractional-order derivative, which has recently acquired popularity for its adaptability in addressing a wide variety of applicable problems and exponential kernel. A fixed point method of Krasnoselskii and Banach is used to determine the main findings. The semi-analytical results are then investigated using iterative techniques such as Laplace-Adomian decomposition method. Computational models are utilized to support analytical experiments and enhance the credibility of the results. These models are useful for simulating and validating the effect of temperature on the complex dynamics of the vector–host interaction during dengue outbreaks. It is essential to note that the research draws on dengue outbreak studies conducted in various geographic regions, thereby providing a broader perspective and validating the findings generally. This study not only demonstrates a novel application of fractional calculus in epidemiology but also casts light on the complex relationship between temperature and the dynamics of dengue transmission. The obtained results serve as a foundation for enhancing our understanding of the complex interaction between environmental factors and infectious diseases, leading the way for enhanced prevention and control strategies to combat global dengue outbreaks.
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