This study investigates the inhibitory characteristics and mechanisms of ABC powder on coal powder explosion using a combination of experimental, theoretical, and numerical methods. In a 20 L spherical explosion experimental system, coal powder was mixed with ABC powder at various mass concentrations. The microstructure and major functional groups of the explosion products were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The proportions of the major functional groups were determined through peak fitting analysis. The research findings demonstrate that the introduction of 60 wt% ABC powder into the coal sample led to a significant decrease in the maximum explosion pressure, from 0.683 MPa to 0.454 MPa, indicating a remarkable reduction of 33.38%. Moreover, the inclusion of 70 wt% ABC powder exhibited complete suppression of coal dust explosions. Thermal decomposition characteristics of the mixed system were investigated using a thermogravimetric analyzer, and the Coats-Redfern integral method was employed to analyze the pyrolysis experimental data. The results suggest that the optimal reaction kinetics models for the combustion stage of coal powder and the mixed system are F1 and F2, respectively. Adding ABC powder increases the activation energy by 27.35% and slows down the pyrolysis rate by 37.97%. Furthermore, numerical simulations using CHEMKIN software were conducted to study the inhibitory effect of ABC powder on coal powder explosion. The results demonstrate that the addition of ABC powder significantly reduces the content of O·, H·, and OH·radicals, which are responsible for sustaining explosive chain reactions within the explosion system. By incorporating the findings of this investigation, the present study offers a comprehensive explication of the intricate micro-level mechanisms that underlie the inhibitory properties exerted by ABC powder on coal dust explosions. These results contribute novel scientific and theoretical foundations, yielding profound insights into the prevention and mitigation of calamitous coal dust explosion incidents within coal mining environments.