This paper presents a case study of using simulation in planning a new Printed Circuit Board (PCB) manufacturing system. The process simulation technique and expert system are proposed to evaluate the design alternatives and logistics management. Simulation results, such as machine utilisation, waiting time, and throughput of system are generated for evaluation. Simulation models were developed using software package SIMPROCESS, which is based on the concept of visual interactive simulation. Besides, the formation of the models is assisted by the expert system package VP-EXPERT. Each approach was found to accurately model the PCB manufacturing plant layout, provide operational and logistics performance in terms of throughput, waiting time, and resource utilisation, and provide a basis for suggesting the best modes of logistics operation.