Field studies were conducted in 1996 and 1997 to evaluate response of eight peanut cultivars to flumioxazin applied preemergence (PRE) at 71 g ai/ha. Peanut cultivars evaluated include ‘NC 12C’, ‘NC 7’, ‘VAC 92R’, ‘NC-V 11’, ‘NC 10C’, ‘AT VC 1’, ‘NC 9’, and the experimental breeding line ‘N9001OE’. Visible injury 3 wk after planting in 1996 was 3% or less regardless of cultivar. In 1997, all cultivars were injured 15 to 28% with flumioxazin PRE, except VC 1, which was injured 45%. No visible injury was observed at 5 and 9 wk after planting. Flumioxazin did not influence the incidence of early leaf spot, late leaf spot, southern stem rot, cylindrocladium black rot, or tomato spotted wilt virus. Flumioxazin did not affect percentage of extra-large kernels, sound mature kernels, other kernels, and total yield.Nomenclature: Flumioxazin; peanut, Arachis hypogaea L., ‘NC 12C’, ‘NC 7’, ‘VAC 92R’, ‘NC-V 11’, ‘NC 10C’, ‘AT VC 1’, ‘NC 9’, ‘N9001OE’.Additional index words: Disease interaction, Cylindrocladium crotalariae (Loos) Bell and Sobers, Cercospora arachidicola Hori, Cercosporidium personatum (Berk. and Curt.), Sclerotium rolfsii Sacc., grade parameters, extra-large kernels, sound mature kernels, sound splits, total kernels, other kernels, fancy pods.Abbreviations: CBR, cylindrocladium black rot; DAP, days after planting; ELK, extra-large kernels; PPI, preplant incorporated; PRE, preemergence; SMK, sound mature kernels; SS, sound splits; TMSK, total sound mature kernels; TSWV, tomato spotted wilt virus; WAP, weeks after planting.