Experience In Management Research Articles

Analysis of problems and management of in vitro diagnostic reagent clinical trials in medical laboratory

Clinical trials are an important method for evaluating the safety and efficacy of in vitro diagnostic reagents, and are a key basis for product registration review and approval. In order to strengthen the management of clinical trials of in vitro diagnostic reagents, the National Medical Products Administration and relevant departments have formulated a series of regulations at the regulatory level, and require applicants and clinical trial institutions to establish a quality management system for clinical trials of in vitro diagnostic reagents. Medical laboratory is the main department and implementer of in vitro diagnostic reagent clinical trials in medical institutions. In recent years, with the rapid development of the in vitro diagnostic industry, the clinical trial projects of in vitro diagnostic reagents conducted by medical laboratory have been increasing day by day. However, there are currently few discussions on the clinical trial of in vitro diagnostic reagents from the perspective of researchers. Therefore, this article summarizes the characteristics of clinical trials of in vitro diagnostic reagents, analyzes the problems and difficulties in conducting clinical trials of in vitro diagnostic reagents in current medical laboratories, and introduces the laboratory's experience in management; to provide reference for medical testing laboratories that have not yet conducted or have already conducted clinical trials of in vitro diagnostic reagents, in order to improve the quality and efficiency of clinical trials.

Enhancing Privacy on Online Social Networs: A comparative study of encryption techniques

The ability to connect with people all over the world and share private information has made online social networks (OSNs) indispensable to contemporary communication. Because of the serious privacy and security concerns that come with their fast growth, protecting user data is of the utmost importance. In order to improve OSN privacy, this study examines several encryption techniques. It discusses symmetric encryption (ECC and RSA) and synthetic encryption (AES) as well as hybrid methods that combine the two types of encryption. Using examples from well-known sites such as LinkedIn, Facebook, and Twitter, the research assesses the efficacy and practicality of various strategies. Key management, performance implications, and user experience maintenance are some of the challenges that are addressed while adopting comprehensive encryption. To further improve privacy protection in OSNs, the paper delves into upcoming developments in encryption technology, such as decentralized encryption approaches and algorithms that are resistant to quantum computing. In order to better understand how to improve OSN security, this article will provide a thorough examination of encryption's function in protecting user privacy.

Cossacks in the Conditions of Frontier Modernization (on the example of the Far East in the late 19th – early 20th centuries)

Historically, the contacts between the Cossacks and the Chinese population were established and their particular strengthening occurred during the construction of the Chinese-Eastern Railway between 1897 and 1903. The imperial authorities devised a plan to establish the Sungurian Cossack army, which was to be augmented by the Cossacks dispatched to protect the ‘KVZhD’. These troops were to comprise the descendants of Albazin and the local population. In the context of the present circumstances, the Cossacks in the peripheral Ussuri Territory and Manchuria served as the frontiers of the system of relations with the local Chinese and Korean populations, as well as the modernizing transformation of the region. As the most mobile and passionate segment of the population, the Cossacks played a pivotal role in the socio-economic and cultural transformation of the region. Their extensive involvement in the agrarian economy and their diverse socio-class and ethno-confessional composition contributed to the diversification of the regional mosaic. During this historical period, the Cossacks served as the driving force of the Russian exploration of the Far Eastern space. Moreover, they facilitated the militarization of the newly developed territories. The format of the study permits presenting a set of relations risen along the Center–Far Eastern Cossacks axis. The objectives of this paper is to ascertain the nature of this relationship within the system and to study the dissemination of the experience of the Cossack self-government system to neighboring regions, including the process of Japanese colonization of the island of Hokkaido. The research findings indicate the efficacy of applying the Cossack administrative and economic management experience to the Far East and Manchuria, as well as in adjacent regions, such as Hokkaido. The article is intended for Cossack specialists and sinologists.

Patient recall of intensive care delirium: A qualitative investigation.

Many patients in the Intensive Care Unit (ICU) experience delirium. Understanding the patient perspective of delirium is important to improve care and reduce suffering. The aim of our study was to investigate the subjective patient experience of delirium, delirium-related distress, and delirium management in ICU. Our study had a qualitative multicenter design applying individual interviews and thematic analysis. Participants were critically ill adult patients that were determined delirium positive according to validated delirium screening tools during ICU admission. The interviews were conducted after ICU discharge when patients were delirium-free as assessed by the "Rapid clinical test for delirium" (4AT) and able to participate in an interview. We interviewed 30 patients choosing the main themes deductively: Delirium experience; Delirium related distress; and Delirium management. Despite variations in recollection detail, ICU survivors consistently reported delirium-related distress during and after their ICU stay, manifesting as temporal confusion, misinterpretations, and a sense of distrust towards ICU staff. Delusions were characterized by a blend of factual and fictional elements. Impaired short-term memory hindered communication and intensified feelings of isolation, neglect, and loss of control. The ICU survivors in our study recalled delirium as an unpleasant and frightening experience, often leading to delirium-related distress during and after their ICU stay, indicating the necessity for enhanced assessment and treatment.

ICG mapping of postoperative lymphatic leakage in the groin: a video article and literature review.

Inguinofemoral lymphoceles are a common postoperative complication after inguinofemoral lymphadenectomy (LNE) and a challenge for patients as well as physicians. We report here our preliminary experience in the surgical management of a recurrent lymphocele using indocyanine green (ICG) detection, followed by robotic-assisted closure of the lymphatic leaks. The aim of this article is to illustrate the surgical steps of ICG-assisted detection of inguinal lymphatic leaks and their surgical treatment by means of robot-assisted suturing. Furthermore, the feasibility of the approach will be evaluated. A 59-year-old woman with locally advanced squamous cell carcinoma of the vulva and previous conventional bilateral inguinofemoral LNE presented with symptomatic therapy-resistant lymphoceles in the groin. After a lengthy and frustrating course of standard therapy, she was offered the off-label option surgical treatment with ICG detection and subsequent robot-assisted ligation of the leaks, using the Da Vinci robotic system™. Perioperative data, specific aspects of the surgical approach specifics, objective and subjective outcomes of the new approach. The procedure was performed as planned, with no intraoperative complications or device-related issues. The postoperative course was uneventful, and the patient developed no further lymphoceles. Visualisation of the leakage by ICG combined with minimally invasive robotic-assisted laparoscopy is a promising therapy option. The pictures and videos demonstrate our experience in regard of the safety, feasibility, and usefulness of this procedure. Further studies will be needed, to prove the absolute efficacy of the technique and express a general recommendation in regard of this approach for the treatment of inguinofemoral lymphoceles.

Lessons from the pandemic: An innovative scheme to support research in the North West Coast

In 2021, a Clinical Research Fellow (CRF) scheme was created to serve the North West Coast (NWC) region in line with the key health priorities set out by the Clinical Research Network. Five doctors in pre-specialist training were placed in NHS trust research departments across the NWC. The scheme aimed to provide early career research experience while also enhancing the provision of research across the region. The CRFs were involved in writing clinical trial grant applications and study protocols, with the scheme providing additional experience in leadership roles and time management. In addition, the CRF scheme has had a positive impact in adopted NHS trusts, which have seen their overall research capacity and capability improve, through increased flexibility and medical oversight. Research departments have benefited from increased financial income and improved national reputations. Overall, this real-world experience provided a vital ‘foot in the door’, which is essential for research-interested medics to advance in a future academic career. In the wider NWC region, the CRF scheme successfully delivered achievable and financially sustainable research. Innovative programmes such as this one should be seen as a viable option for research provision through the NHS, in the UK.

Exploring the Experience of Pain and Pain Management for Pregnant and Postpartum Veterans with Chronic Musculoskeletal Pain

BackgroundTo examine how veterans experience and treat pain during the perinatal period, we conducted a qualitative study to explore the experiences of pain, pain management, and facilitators and barriers to treatment among perinatal veterans. MethodsWe identified veterans who received care at any of the 15 Veterans Health Administration (VHA) facilities across the United States and were enrolled in an ongoing cohort study. All participants gave birth to a newborn between March 2016 and June 2021 and met the inclusion criteria for having a prepregnancy pain-related musculoskeletal condition. We completed interviews with 30 veterans between November 2021 and January 2022. We used a framework approach to our qualitative analysis. ResultsVeterans in our sample were, on average, 31 years of age, married (80%), and white (47%). The most common type of pain diagnoses were back pain (93%) and joint disorders (73%). We identified the following major themes: 1) veteran experiences of pain during pregnancy, 2) challenges to pain care during the perinatal period, and 3) veteran recommendations for VHA perinatal pain care. Experiences of pain during pregnancy varied and several barriers to pain care were identified. Veterans suggested several ways the VHA could improve pain care during the perinatal period, including more training for VHA providers on perinatal pain care and greater complementary and integrative health coverage. ConclusionsUnderstanding the unique needs of pregnant veterans with chronic pain is important to provide high-quality care during the perinatal period. Veterans who participated in this study highlighted several areas where the VHA could improve pain management during pregnancy and postpartum.

Factors Associated with Nurse Preparedness in Handling Disaster Victims in Central Sulawesi

Several factors influence nurses' preparedness in handling disaster victims. This study aims to identify the factors associated with nurses' preparedness to manage Central Sulawesi disaster victims. Conducted between April and July 2023, this cross-sectional quantitative study involved 124 nurses from Undata Hospital, Anutapura Hospital, Madani Hospital, Bhayangkara Hospital, and Dr. Sindhu Trisno Hospital, selected through total sampling. Preparedness was measured using the Disaster Preparedness Evaluation Tool (DPET). At the same time, knowledge, attitudes, and experiences in disaster management were assessed with the Knowledge, Attitude, and Practices of Disaster Management (KAP DM) questionnaire. Data were analyzed using chi-square and linear regression tests. The chi-square results indicated significant relationships between preparedness and knowledge (p=0.004), attitude (p=0.045), length of service (p=0.037), participation in disaster training (p=0.004), and experience in disaster management (p=0.028). At the same time, education level showed no significant relationship (p = 0.075). Linear regression revealed that knowledge had the strongest influence on preparedness. The study concludes that knowledge, attitudes, length of service, disaster training, and disaster management experience are key factors affecting nurses' preparedness. It is recommended that emergency nurses regularly participate in disaster-related training to enhance their ability to provide timely medical assistance, thereby reducing disaster-related mortality.

Leveraging AI and Machine Learning for Performance Optimization in Web Applications

The rapid evolution of web technologies has placed an unprecedented demand on web applications to deliver high performance, scalability, and responsiveness. In this context, Artificial Intelligence (AI) and Machine Learning (ML) have emerged as transformative tools that can significantly optimize the performance of web applications. This paper explores the integration of AI and ML techniques in enhancing various aspects of web application performance, including load balancing, caching, resource management, and user experience personalization. The deployment of AI-driven algorithms enables real-time monitoring and predictive analytics, allowing for proactive adjustments to prevent bottlenecks and ensure smooth operation under varying loads. One of the primary areas where AI and ML contribute is in load balancing. Traditional load balancing techniques often rely on static or rule-based methods, which may not adapt well to dynamic web environments. AI-powered load balancers, however, can learn from traffic patterns and predict surges in demand, enabling more efficient distribution of traffic across servers. This adaptive approach not only improves response times but also reduces the risk of server overloads, enhancing the overall reliability of web applications.

Nirmatrelvir/ritonavir: real world drug–drug interaction management experience

ABSTRACT Background In the UK, a regional vertical system for the delivery of COVID-19 medicines has been in place. This enabled centralization of expertise in risk stratification of patients, and in understanding and mitigating drug–drug interactions. Research design and methods We analyzed real-world drug–drug interactions in adult patients referred for nirmatrelvir/ritonavir therapy across one such geographic area covering 2.2 million London citizens. Results Among 208 who received NMV/r therapy, we identified 184 potential DDIs, 8% precluded nirmatrelvir/ritonavir use, 53% required management, but 56% of these did not have documented advice to hold therapy. Conclusions This highlights the need to maintain and develop pathways for clinical pharmacology expertise in COVID-19 management.

DINAMIKA GENERASI SANDWICH DALAM PENGELOLAAN KEUANGAN : SEBUAH STUDI FENOMENOLOGI

The purpose of this study is to investigate the significance of the sandwich generation's financial management experiences in challenging financial times. Qualitative research design using interpretive phenomenological approach was employed. Three individuals who embodied the sandwich generation were interviewed in-depth in order to gather data. The Interpretative Phenomenological Analysis method was employed to examine the interview results. The findings of this study suggest that the elements that drive informants to fulfill their role as a sandwich generation include favorable attitudes, subjective norms, perceived behavioral control, and felt religiosity. Based on his interpretation of the event, the informant experienced good emotions such as pride and believed that taking on this responsibility was a way of showing his parents love

Driving Local Development with Social Engineer Approaches by Rajabhat University Students

Background and Aims: Social Engineering approaches are important for university students because they teach critical skills such as understanding human behavior and managing relationships, both of which are required for effective communication and leadership. These abilities not only improve their academic and professional interactions but also prepare them for real-world challenges by honing their ability to influence and motivate others ethically. This paper aims to explore how Rajabhat University students are utilizing social engineering approaches to drive local development. Methodology: The documentary research approach used in this review provides a thorough analysis of social engineering strategies by reviewing project reports, student records, and stakeholder interviews. This methodology combines thematic, comparative, and impact assessments to provide a thorough understanding of the effectiveness and challenges of these initiatives. Results: The finding found that Rajabhat University's student-led initiatives have significantly influenced local development by improving community health, promoting environmental sustainability, and preserving cultural heritage. The "Community Health Awareness Campaign" increased health literacy and community engagement, whereas the "Green Campus Initiative" improved environmental practices and reduced waste. The "Local Art and Culture Festival" helped to strengthen cultural ties while also providing valuable event management experience. Despite these accomplishments, challenges such as engaging hard-to-reach populations, sustaining participation, and managing logistics necessitated strategic solutions. Overall, these initiatives demonstrate the importance of student involvement in promoting community development and provide valuable insights for future projects. Conclusion: The findings show that Rajabhat University's student-led initiatives have had a significant impact on local development, including improved health, environmental sustainability, and cultural preservation. These efforts highlight the importance of student engagement in driving community progress and provide valuable lessons for future endeavors.

Children with Cerebral Palsy and Their Parents Have Different Experiences of Pain Management: A Qualitative Study.

Aim: The aim of this study is to explore and compare experiences of pain management strategies for children with CP from the perspectives of children themselves and their parents. Methods: A secondary inductive analysis of previously collected qualitative data was performed. Fourteen children with CP and one parent of each child were interviewed separately about the management of the child's pain. A dyadic data analysis was used to compare parents' and children's perspectives. Findings: The main thematic categories of pain management identified were self-care, psychological strategies, physical interventions and professional treatment. Experiences described by the child and parent differed within all participating dyads but to different degrees. On a group level, children described more use of psychological strategies than parents did. Parents described more professional treatment strategies. Conclusions: Parents and children described different experiences of pain management strategies, and both perspectives are needed to understand the child's situation.

International aid management in Afghanistan’s health sector from the perspective of national and international managers

PurposeThe primary purpose of international aid is to promote economic and social development around the world. International aid plays an important role in Afghanistan’s healthcare system. The purpose of this study is to investigate international aid management in Afghanistan’s health sector from the perspectives of national and international managers in 2022 and to provide recommendations for the improvement.Design/methodology/approachThe study has a cross-sectional design. The study participants were chosen by random sampling. The sample size was determined based on Yaman’s formula at 110. The data collection tool was the questionnaire provided by International Health Partnership and Related Initiatives. The data were analyzed in two descriptive (mean and percentage) and analytical formats. Independent t-test, Mann-Whitney, Kolmogorov-Smirnov tests and Variance analysis were used to examine the relationships between demographic variables and the scores of each dimension.FindingsThe average scores given to different dimensions of aid management were as following: 1) the donners’ support of the national health strategy: 48/68 ± 16.14 (49%), 2) the predictable financing: 50/23 ± 16.02 (50%), 3) foreign aid on budget: 55/39 ± 20.15 (55%), 4) strengthening public financial management system: 38/35 ± 19.06 (38%), 5) strengthening the supply and procurement system: 40.97 ± 19.55 (41%), 6) mutual accountability: 46.50 ± 19.26 (46%), 7) technical support and training: 50.24 ± 17.33 (50%), 8) civil society involvement: 35.24 ± 18.61(35%), 9) private sector participation: 36 ± 17.55 (36%), and in total the average score was 44.52 ± 13.27 (44%). The difference between the scores given by two groups of managers was not significant. No meaningful relationship was observed between the total score and any of the demographic variables, but there was a weak relationship between work and management experience and total score. The correlation coefficient showed a statistically significant relationship between the different dimensions of the questionnaire. To sum up, the performance in all dimensions of aid management hardly reached 50%. Donors’ support for the national health strategy was not adequate. There were challenges in evidence-based decision-making, developing national health strategies, control and evaluation, the allocation of resources and use of procurement system. The priorities of donors and government were not always similar and mutual responsibility was lacking. Technical assistance and supporting multilateral cooperation are necessary.Originality/valueMost studies on foreign aid focused on its effects on economic growth, poverty and investment and not aid management processes. Without proper aid management, parts of resources are wasted and aims of aid programs cannot be achieved. This study investigates aid management in a developing country from the perspectives of two main stakeholders, international and national managers.Research limitations and implicationsData collection coincided with the change of government in Afghanistan. The situation might be different now. Still, this study provides areas for the improvement of aid management in the studied country. Future studies can build upon the findings of this research and conduct in-depth exploration of areas of aid effectiveness and designing detailed programs of improvement.Practical implicationsInstructions of the Paris Declaration on Aid Effectiveness need to be followed. Particularly, civil society involvement and private sector participation should receive attention. A joint plan for improvement and collaboration of different stakeholders is needed.

RHABDOMYOLYSIS: WHEN TO SUSPECT AND WHAT TO DO NEXT? BRIEF OVERVIEW OF THE PROBLEM, DESCRIPTION OF THE CLINICAL CASE

Summary: rhabdomyolysis is a condition that occurs quite often in patients with severe trauma, where there is massive damage to muscle tissue, which in turn leads to the release of myocyte breakdown products and can lead to life-threatening conditions. The article highlights the problem of rhabdomyolysis, timely diagnosis and intensive therapy. A review of information sources for the last five years regarding methods of diagnosis and management of this category of patients was carried out. A description of a clinical case with this problem and own experience of diagnosis and management of such a patient is presented.

Investigating the moderating role of technology turbulence and innovation capabilities in servant leadership, knowledge management and frugal innovation

Purpose This research aims to investigate the impact of servant leadership on knowledge management and its subsequent connection to cost-saving innovation. The study further explored these relationships by examining the mediating roles of innovation capabilities and technological volatility. Design/methodology/approach The research is applied in purpose and employs a descriptive-survey method for data collection. It follows a qualitative-quantitative approach, utilizing expert interviews in the qualitative phase. The sample consists of 35 managers and expert professors with knowledge management experience in universities and high-tech industries, selected through the snowball method. Data collected from Iranian organizations were analyzed using AMOS software. Findings The results revealed a positive correlation between servant leadership and knowledge management. Knowledge management demonstrated a significant positive relationship with cost-saving innovation. Additionally, technological volatility and innovation capabilities were identified as crucial factors influencing the connection between knowledge management and innovation, particularly in promoting frugality. Originality/value While this research provides a comprehensive model, it acknowledges specific limitations that warrant further investigation. The study predominantly focused on Iranian organizations, suggesting an opportunity to broaden its scope to include diverse organizational perspectives from various cultural and geographical contexts. Moreover, a promising avenue for future research involves exploring entrepreneurial orientation as a potential mediating variable. Given its significant impact on organizational dynamics, introducing entrepreneurial orientation could enhance our understanding of its effects on both knowledge management and the promotion of frugal innovation. This expansion may illuminate the intricate interplay between entrepreneurial orientation, knowledge processes and innovative practices, contributing to a more sophisticated discussion on effective organizational strategies.

Masjid-based Disaster Management: How Masjids in Malaysia Support the Needy

The COVID-19 pandemic and the great flood of 2021 significantly impacted society. However, masjids have proven effective institutions in disaster management efforts, particularly in social welfare. This study examines the role of masjids in managing disasters in Malaysia, specifically during the 2021 great flood and the COVID-19 pandemic. The qualitative research involves in-depth interviews based on case studies, with the results analyzed thematically. A total of 14 masjids as informants were selected from across Malaysia, including nine of the best masjids in 2021 and five with disaster management experience. The findings reveal that masjids are crucial in disaster management, encompassing services, health, placement, incentives, and infrastructure. These contributions help effectively manage the community during disasters. The study highlights two key factors contributing to the success of masjids in disaster management: the core concern of maqasid sharʿiah and the synergy of da’wah in strengthening the relationship between masjids and the community. The implications of this study contribute to both theory and practice, particularly in designing ideal masjid management, preserving community welfare, and maintaining the Sustainable Development Goals (SDGs).

Perceptions of sustainable human resource management (SHRM) and personal risk: Findings from the Pilot Study.

The aim of this article is to explore how SHRM (Sustainable Human Resource Management) practices and personal risk management are interpreted by managers across different organisational contexts, and to identify challenges and barriers to implementing these practices. The study focuses on a variety of SHRM approaches in diverse organisational contexts, highlighting the impact of company size, managerial experience, and organisational culture. It also explores the challenges associated with both long-term and short-term SHRM goals and underscores the need for a better understanding and communication of these practices within organisations. The study is based on a qualitative individual in-depth interview (IDI) methodology. The results of the study highlight the importance of adapting and understanding the unique aspects of each organisation to effectively implement SHRM. The article contributes to the literature by highlighting the need for further research into holistic SHRM models, the management personal risk, the use of new technologies, and the development of advanced measurement methods.

Knowledge and Perceptions about Diagnosis, Clinical Management, and Prevention of Dengue Fever among Physicians during the 2023 Outbreak: A Cross-Sectional Study in Peru.

The objective of this study was to evaluate the knowledge level and perception of dengue fever management among Peruvian physicians and to determine the factors associated with higher knowledge. We conducted an analytical cross-sectional study based on an online survey. To evaluate the factors associated with a high level of knowledge (≥70% of correct answers), we used crude (cPR) and adjusted (aPR) prevalence ratios by the Poisson regression model. Of 359 respondents (median age: 33 years; male: 56.5%), 78.8% achieved a high level of knowledge. Multivariable analysis showed an independent association with having read the Peruvian clinical practice guidelines for dengue management (aPR: 1.29; 95% CI: 1.12-1.49), having experience in treating patients (aPR: 1.32; 95% CI: 1.03-1.68), and having treated cases frequently (aPR: 1.22; 95% CI: 1.02-1.46). Residing in the eastern macroregion (aPR: 0.83; 95% CI: 0.71-0.97) was associated with a low level of knowledge. In conclusion, Peruvian physicians had a high level of knowledge about dengue fever. This was associated with having clinical experience in dengue management. However, given the low level of knowledge in the eastern macroregion, educational campaigns are necessary in this area.

An Orderly Charging and Discharging Strategy of Electric Vehicles Based on Space–Time Distributed Load Forecasting

Given the widespread adoption of electric vehicles, their charging load is influenced not only by vehicle numbers but also by driving and parking behaviors. This paper proposes a method for forecasting electric vehicle charging load based on these behaviors, considering both spatial and temporal distribution. Initially, the parking generation rate model predicts parking demand, establishing the spatial and temporal distribution model for electric vehicle parking needs across various vehicle types and destinations. Subsequently, analyzing daily mileage and parking demand distributions of electric vehicles informs charging demand assessment. Using the Monte Carlo simulation method, large-scale electric vehicle behaviors in different spatial and temporal contexts—parking, driving, and charging—are simulated to predict charging load distributions. Optimization of electric vehicle charging and discharging enhances grid stability, cost management, charging efficiency, and user experience, supporting smart grid development. Furthermore, charging load forecasting examples under diverse scenarios validate the model’s feasibility and effectiveness.