The aim of the present study was to examine the understudied immigration and acculturation experience of the growing Latino/a community in Canada. Specifically, we explored the impact of race-based rejection sensitivity on well-being, and whether cultural identity clarity could help curtail any negative effects. Hypothesis 1 was that race-based rejection sensitivity would be negatively associated with well-being. Hypothesis 2 was that cultural identity clarity would moderate the association between race-based rejection sensitivity and well-being such that Latino/a immigrants lower in cultural identity clarity would experience poorer well-being than those higher in cultural identity clarity. A community sample of Latino/a immigrants (N = 136; Mage = 38.21; 51.47% female) completed a survey including measures of race-based rejection sensitivity, cultural identity clarity, bicultural stress, self-esteem, and life satisfaction. Correlation and regression analyses revealed that race-based rejection sensitivity was negatively associated with well-being. Additionally, high cultural identity clarity attenuated the negative association between race-based rejection sensitivity and well-being. Results of the present study suggest maintaining clarity over their heritage cultures postimmigration can be beneficial to Latino/a immigrants in Canada, in particular when they are sensitive to cues of racial discrimination. (PsycInfo Database Record (c) 2020 APA, all rights reserved).