Real Experiments Research Articles

Oppressive expression and the Czech and Slovak communities of Northern Ireland

Feminist philosophers of language have, in the last several decades, demonstrated the usefulness of employing a speech-act theoretical lens to understand how expression works to enact and reinforce oppression. Despite the growing influence of these approaches in the philosophy and political theory literature, however, their use in other disciplines remains severely limited. This is surprising, especially given the real potential of the speech-act approach to illuminate the mechanisms by which everyday acts contribute to large-scale oppressions. This paper takes up this call for interdisciplinarity, utilising a speech-act theory of oppression to better understand the real-life experiences of the under-researched Czech and Slovak communities of Northern Ireland. Using semi-structured interviews followed by thematic analysis, our study expands our understanding of oppressive speech by revealing a complex relationship between victims’ experiences and their understanding of wider societal oppression, exposing a channel via which victims can exercise agency by contesting attempts to reinforce their oppression. In so doing, the study also draws attention to a novel theoretical lens with which to understand experiences of harmful speech, one which is currently under-utilised by those outside of the philosophy/political theory disciplines.

8.B. Scientific session: Strengthening health information systems in the European Region

Abstract Strong health information systems (HIS) are essential for robust, evidence-informed policymaking and decision making in all levels of healthcare. The COVID-19 pandemic underscored the vital importance of HIS, but also highlighted flaws and weaknesses across HIS in Europe. Common HIS challenges include limited resources and capacity; insufficient coordination and collaboration between HIS stakeholders, leading to fragmentation and problems with interoperability; lack of central governance; and limited use of health information for decision-making. Both at the level of the WHO Regional Office for Europe (WHO/Europe) and the European Commission, policies and strategies are being implemented to support Member States in strengthening their HIS, thereby improving the availability of high quality, timely data for evidence-informed decision making, both at the country and international level. Supporting the further digitalization of HIS is an important element in this. In 2023, WHO/Europe and the European Commission joined forces in the field of HIS strengthening. This workshop will inform participants about current and future capacity building tools and activities that will be implemented under the umbrella of the EU-funded action ‘Supporting Member States in the WHO European Region in strengthening HIS and boosting health data governance and interoperability’. It will explain the policy as well as situation-on-the-ground contexts in which the action will be implemented. The workshop will start with a (1) presentation by WHO/Europe on the current HIS situation in the Region and what are the main priority areas in WHO’s work for the coming years. After that, (2) the European Commission will give more information on the above-mentioned EU-funded action and the related EU policy landscape, most notably the European Health Data Space (EHDS). Next, (3) WHO/Europe will present their catalogue of capacity building tools and activities, and share experiences with implementing these. Finally, (4) HIS modernization cases with enabling factors and challenges will be presented based on different countries’ real life experiences, illustrating the impact of HIS strengthening activities at the country level. Workshop participants will get a comprehensive overview of available HIS strengthening tools and activities in the European Region. This will help them in selecting and applying tools for strengthening their own national or regional HIS, and ensuring their HIS is prepared for aligning with the EHDS and other important policies and strategies. This will contribute to sustainable and future-proof HIS across Europe. During the workshop, there will be ample time for questions and discussion. In the discussion, participants will be asked whether they have any HIS strengthening needs that are not yet covered in the current package of tools and activities. This will help WHO and the European Commission to further harmonise their efforts with what is needed on the ground. Key messages • Despite investments in HIS following the COVID-19 pandemic, many challenges remain, which are often similar across European countries. • WHO/Europe and the European Commission have joined forces to strengthen HIS and boost health data governance and interoperability, while leveraging EHDS developments.

Real-life experience with rilonacept for the treatment of recurrent pericarditis

Abstract Background Rilonacept, a soluble Interleukin-1 (IL-1) receptor fusion protein that neutralizes IL-1α and IL-1β, has shown efficacy in symptom resolution, weaning of standard-of-care therapies, and reducing the frequency of recurrent pericarditis (RP) episodes in clinical trials. Purpose We aimed to review the efficacy, safety, and duration of treatment with Rilonacept reliance in managing RP in our practice. Methods We analyzed 22 patients with RP treated with Rilonacept, 55 [43-69] years, 11 (50%) females. We reviewed clinical characteristics and outcomes, including the time since initial diagnosis of pericarditis, the presence of pericardial effusion/thickening, the duration of Rilonacept treatment, the ability to wean off steroids, and the recurrence of pericarditis symptoms attempting discontinuation. Results The length of time from the initial diagnosis of pericarditis to Rilonacept initiation was 9 [4-32] months. Fifteen patients out of 22 (68%) had pericardial effusion, 3 (20%) with tamponade requiring pericardiocentesis. Median length of treatment with Rilonacept was 14 [6-23] months, with 17/22 (77%) of patients being treated for ≥ 6 months. All patients who were on steroids (14/22, 64%) were able to discontinue their usage 1 [1-9] months after starting Rilonacept. Of the seventeen who were treated for 6 months or more, 12 (70%) remained on Rilonacept 160 mg weekly at the most recent assessment, 3 (18%) continued treatment with Rilonacept 160 mg every 2 or 4 weeks, and 2 (12%) discontinued Rilonacept treatment after 6 and 50 months. Of the 12 patients who remained on weekly treatment after a period of 6 months, 8 (67%) required Rilonacept for symptom control, 1 (8%) had recurrent symptoms after treatment every 2 weeks, and the remaining 3 (25%) preferred to continue despite a lack of symptoms (Figure 1). Conclusions The efficacy of Rilonacept in treating patients with RP and the ability to stop steroid therapy in the real world is in line with the efficacy data from clinical trials.Figure 1

Clinical value of anti-DSG2 antibodies in arrhythmogenic right ventricular cardiomyopathy: a real-life experience

Abstract Background/Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease leading to ventricular arrhythmias and heart failure. The diagnosis is challenging and currently based on a set of clinical criteria with limited sensitivity and specificity. Anti-desmoglein-2 (DSG2) antibodies were previously found in patients diagnosed with ARVC, while they were absent in both healthy controls and athletes. Purpose The study aimed to evaluate the diagnostic value of anti-DSG2 antibodies by comparing their concentration in patients with ARVC and other right ventricular diseases. Additionally, the prognostic value of the biomarker was assessed. Methods A cohort of 101 patients with a definite diagnosis of ARVC according to the 2010 Task Force criteria was enrolled (64 males, mean age 47 ± 16 years). The control group included patients with Ebstein anomaly and Eisenmenger syndrome (16 and 21 subjects, respectively). Anti-DSG2 antibody concentration was assessed using enzyme-linked immunosorbent assay (ELISA). After that, an ARVC cohort was followed for 3.9 ± 1.6 years for the occurrence of the primary endpoint of cardiac death or heart transplantation (HTx) and major arrhythmic events (MAEs) defined as ventricular fibrillation, sustained ventricular tachycardia (sVT) or appropriate implantable cardioverter-defibrillator intervention. Results The median anti-DSG2 antibody concentration presented as ELISA optical density (OD) reached 1.36 [0.54-2.15] in the ARVC cohort, while it was 0.4 [0.34-0.54] in Ebstein anomaly group and 0.36 [0.28-0.58] in the Eisenmenger syndrome group. There was a significant difference in antibody levels between ARVC and both control groups (p < 0.001, Figure 1). The cutoff value for the diagnosis of ARVC was 0.774, with 72.3% sensitivity and 100% specificity (AUC = 0.823). After dividing the ARVC cohort according to the designated cutoff point, the anti-DSG2-positive subgroup was significantly younger (44.5 ± 15.4 vs. 52.8 ± 15.5 years, p = 0.017) and more likely to have a history of sVT (68.5% vs. 46.4%, p = 0.041). There was no difference regarding sex, presence of PKP2 or DSG2 mutations, previous sports activities, history of sudden cardiac arrest or syncope, right ventricular dimensions and systolic function, left ventricular ejection fraction and heart failure symptoms. This threshold was not predictive for the primary endpoint and MAEs. However, a more stringent cutoff value for anti-DSG2 level (1.021) was found to predict death or HTx (HR [95% CI] 4.56 [1.05-19.76], p = 0.026, Figure 2). Conclusions The concentration of anti-DSG2 antibodies is significantly higher in ARVC compared to other right ventricular diseases. A high antibody level is prognostic for death or HTx in ARVC.Figure 1Figure 2

Influence of a three-dimensional mapping system on acute safety and efficacy of pulsed-field ablation for atrial fibrillation

Abstract Background Visualization of the multi-electrode pulsed-field ablation (PFA) catheter within a 3D-mapping system holds the potential to improve catheter maneuverability and enhance ablation outcomes, thereby improving procedural metrics. Purpose The aim of our analysis, from a real-world nationwide registry, is to evaluate the impact of 3D-mapping system on acute safety and efficacy in the context of PFA of atrial fibrillation (AF). Methods All consecutive patients undergoing de novo AF ablation with the Farapulse system at 13 centers were included. Protocol-directed PVI was delivered using 2kV with 8 applications per vein, that is, 4 applications each in the basket and flower poses. Additional lesions were performed at the operator’s discretion. Procedures were stratified according to the use or not of 3D-mapping system to validate the lesions (MAP vs Standard). Results Among 1002 patients, 28.3% were females, 28.2% had persistent AF, mean age was 62.9±10 years, mean LVEF was 57.4±8%. A more extensive lesion set than PVI only (PVI plus) was performed in 230 (23.0%) of the cases. A 3D-mapping system was used to validate the lesion set in 201 (20.1%) of the cases, mostly when a more extensive lesion set was applied (40% in PVI plus vs 14.1% in PVI only, p<0.001). Four-thousand forty-five (99.1%) PVs were acutely isolated on first pass (26 patients with at least 1 PVs not isolated at first pass, 2.6%), as confirmed by both entrance/exit block and/or on subsequent 3D-mapping. No differences between MAP and Standard procedures were found in terms of first pass PVI (98.8% vs 99.1%, p=0.416) or number of patients with all PV isolated at first pass (95.5% vs 97.9%, p=0.079). At the end of the procedure PVI was achieved in all patients. By looking at procedural metrics, the total number of PFA deliveries (43±12 vs 39±10, p<0.0001) and PFA deliveries outside PVs (19.6±8 vs 15.1±6, p<0.0001) were higher in the MAP group, whereas the number of PFA deliveries to achieve PVI were lower (34±4 vs 36.4±7, p<0.0001). MAP procedures had longer skin-to-skin time (94[80-120]min vs 60[50-70]min, p<0.0001), time to PVI (20[15-27]min vs 18[14-24]min, p=0.0001) or fluoroscopy time (22[18-29]min vs 14[11-18]min, p<0.0001). The MAP group exhibited increased skin-to-skin time and fluoroscopy time, even when analyzing procedures separately for those involving PVI only and those involving PVI plus. Conversely, the total number of PFA deliveries to achieve PVI (53.8±8 vs 53.3±10, p=0.254) and time to PVI (17.5[14.5-22]min vs 18[12-25]min, p=0.516) were comparable between MAP and Standard groups during PVI plus. No major complications occurred in both groups. Conclusion In our real-life experience, the use of Farapulse PFA system for de novo AF ablation was rapid, safe and acutely effective resulting in a very high first-pass isolation rate. 3D-mapping system was used in a minority of patients and was not associated with an increase in acute success-rate.

Experiences of Patients With Cancer Using Electronic Symptom Management Systems: Qualitative Systematic Review and Meta-Synthesis.

There are numerous symptoms related to cancer and its treatments that can affect the psychosomatic health and quality of life of patients with cancer. The use of electronic symptom management systems (ESMSs) can help patients with cancer monitor and manage their symptoms effectively, improving their health-related outcomes. However, patients' adhesion to ESMSs decreases over time, and little is known about their real experiences with them. Therefore, it is necessary to gain a deep understanding of patients' experiences with ESMSs. The purpose of this systematic review was to synthesize qualitative studies on the experiences of patients with cancer using ESMSs. A total of 12 electronic databases, including PubMed, Web of Science, Cochrane Library, EBSCOhost, Embase, PsycINFO, ProQuest, Scopus, Wanfang database, CNKI, CBM, and VIP, were searched to collect relevant studies from the earliest available record until January 2, 2024. Qualitative and mixed methods studies published in English or Chinese were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement checklist) and the ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) statement were used to improve transparency in reporting the synthesis of the qualitative research. The Critical Appraisal Skills Program (CASP) checklist was used to appraise the methodological quality of the included studies, and a meta-synthesis was conducted to interpret and synthesize the findings. A total of 21 studies were included in the meta-synthesis. The experiences of patients with cancer using ESMSs were summarized into three major categories: (1) perceptions and attitudes toward ESMSs; (2) the value of ESMSs; and (3) barriers, requirements, and suggestions for ESMSs. Subsequently, 10 subcategories emerged from the 3 major categories. The meta-synthesis revealed that patients with cancer had both positive and negative experiences with ESMSs. In general, patients recognized the value of ESMSs in symptom assessment and management and were willing to use them, but they still encountered barriers and wanted them to be improved. This systematic review provides implications for developing future ESMSs that improve health-related outcomes for patients with cancer. Future research should focus on strengthening electronic equipment and technical support for ESMSs, improving their functional contents and participation forms, and developing personalized applications tailored to the specific needs and characteristics of patients with cancer. PROSPERO CRD42023421730; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=421730.

Eight year Follow-Up Data on a Leadless Pacing System Real life experience in comparison to data of the prospective trial

Abstract Introduction The Micra leadless intracardiac pacing system has been introduced and implemented into clinical routine in 2015, with its next generation MICRA AV in 2020. Feasibility, implantation safety, and acute success have been proven in the setting of controlled studies. Even apart from controlled studies, this new technology was beneficial for the individual patient. We aimed to report our single center follow-up (FU) data with a follow-up of up to six years. Methods In 292 patients (146 men; age: 81±5,7 y), Micra implantation was performed. Pacemaker interrogation was performed one to seven days after implantation and during FU (1; 3; 6, then every 6 month) up to 84 months. Data were assessed in a real-life setting and compared with existing data of a controlled prospective trial. Results The implantation was successful in all 292 attempts with only one pericardial effusion as major complication. During follow up there were two patients developing severe heart failure symptoms resulting in an implantation of a CRT-device and switching of the leadless pacemaker system. The average acute thresholds, sensing and impedance after system release were: 0.57±0.34V@0.24ms; 10,02±3,96mV and 752±1201Ohm. During follow up of up to 8 years neither, pacemaker failure, nor infections were reported. Measurements were reevaluated for long-term thresholds, sensing and impedance: 0.75 ± 0.38V @ 0.24 ms; 18,38 ±2,75 mV and 525 ± 102 Ohm. During eight years, no significant changes from acute to long-term measurements were detectable. In comparison to the controlled trial, our measurements of this real-life cohort were very similar. Conclusion In a real-life setting, the implantation of the leadless Micra system demonstrates a high rate of implantation success without major complications. We were also able to show stable long-term system parameters in the clinical setting of up to seven years of follow up with a very good battery longevity of about 12,3 years.

The Impact of Virtual Immersive Public Art on the Restorative Experience of Urban Residents

This study explores the role of virtual immersive public art in improving the psychological well-being of urban residents. The research is set in the context of urban environments, where virtual immersive public art has the potential to foster innovation, integrate technology, and organically blend into public spaces. The study evaluates the impact of such art on psychological restoration by focusing on three key dimensions: interactive themes, interactive mechanisms, and artistic characteristics. A questionnaire survey was conducted to collect participants’ real-life experiences and reactions to these art installations. The results show that virtual immersive public art significantly contributes to the restorative experience of urban residents, offering valuable insights into how these installations can promote mental health. Based on the findings, the study provides practical design recommendations for incorporating virtual immersive public art into future urban planning and design projects to enhance urban living conditions and support psychological recovery.

The influence of the volume fraction of meat in dumplings on their cooking time

Based on the studied literature, the aim was to investigate the influence of the volume fraction of meat in meat dumplings (pelmeni) and the number of dumplings on their cooking time, as well as to analyze the physico-mathematical and technical aspects to be taken into account (or not) within the framework of the planned experiment. To achieve this goal, the following tasks were set: to conduct experimental studies, to describe the assumptions that need to be accepted when performing the study and to conduct theoretical studies (numerical experiments, using the finite element method). When conducting experiments, dumplings of well-known brands, the names of which were conventionally labeled as “SK”, “SZ”, “RE”, “TS”, were chosen as objects of research. The need to study the dumplings of well-known brands is justified by both consumer interest and a smaller variability of product parameters, which increases the reproducibility of the results of the study. As assumptions adopted in real experiments, the authors emphasize the following ones: distilled water is used in cooking, the volume of a dumpling does not change during cooking, the biochemical composition of the filling can be neglected. As a result of the theoretical analysis, the following assumptions were made: the study of dumpling cooking does not take into account the resistance forces, i. e., turbulent and convective flows, as well as thermo-elastic effects; the time of dumpling floating to the surface is negligibly small; "approximation of initial values" — geometric, physico-chemical parameters of the dumpling do not change during cooking. Cooking time of 1, 5, 10 dumplings of known brands was obtained on the basis of numerical experiments. Using real experiments, the time from immersion of the dumplings in water to their floating to the surface was investigated. As a result of numerical experiments it has been found that the time of heating the center of the dumpling of known brands to the temperature of protein denaturation differs from the time of floating to the surface by about 360 seconds. Consequently, after floating to the surface, the dumplings of known brands need about six more minutes of cooking time until they are fully cooked.

The real experiences of nurses after patient suicide: A meta-synthesis of qualitative studies.

To systematically evaluate the qualitative study of nurses' real experience after patient suicide, and to provide theoretical basis for reducing the influence of patient suicide on nurses and reducing the incidence of patient suicide. A systematic review and meta-synthesis of qualitative studies. These databases including The Cochrane Library, CINAHL, PubMed, Embase, Web of Science, CMB, CNKI, Wanfang, and VIP were searched by computer to collect relate qualitative researches. The retrieval time was from database established to February 2024. Joanna Briggs Institute Qualitative Research Quality Evaluation Form was used to evaluate the literature quality and Meta-integration. A total of 12 studies were included and 47 results were obtained, which were summarized into 8 new categories and 3 integrated results were obtained. Theme 1: impact on nurses themselves; Theme 2: the nurse's thoughts and suggestions of patient suicide; Theme 3: coping strategy. Nursing managers should fully pay attention to nurses' feelings and cognitive attitudes after patients' suicide events, strengthen psychological counseling for nurses, so as to reduce the impact of patients' suicide events on nurses.

A Modified TCP BBR to Enable High Fairness in High-Speed Wireless Networks

Wireless networks, especially 5G and WiFi networks, have made great strides in increasing network bandwidth and coverage over the past decades. However, the mobility and channel conditions inherent to wireless networks have the potential to impair the performance of traditional Transmission Control Protocol (TCP) congestion control algorithms (CCAs). Google proposed a novel TCP CCA based on Bottleneck Bandwidth and Round-Trip propagation time (BBR), which is capable of achieving high transmission rates and low latency through the estimation of the available bottleneck capacity. Nevertheless, some studies have revealed that BBR exhibits deficiencies in fairness among flows with disparate Round-Trip Times (RTTs) and also displays inter-protocol unfairness. In high-speed wireless networks, ensuring fairness is of paramount importance to guarantee equitable bandwidth allocation among diverse traffic types and to enhance overall network utilization. To address this issue, this paper proposes a BBR–Pacing Gain (BBR–PG) algorithm. By deriving the pacing rate control model, the impact of pacing gain on BBR fairness is revealed. Adjusting the pacing gain according to the RTT can improve BBR’s performance. Simulations and real network experiments have shown that the BBR–PG algorithm retains the throughput advantages of the original BBR algorithm while significantly enhancing fairness. In our simulation experiments, RTT fairness and intra-protocol fairness were improved by 50% and 46%, respectively.

Survey on haptic technologies for virtual reality applications during COVID-19

<p>This paper presents a comprehensive survey on the advancements and applications of haptic technologies, which are methods that facilitate the sense of touch and movement, in virtual reality (VR) during the COVID-19 pandemic. It aims to identify and classify the various domains in which haptic technologies have been utilized or can be adapted to combat the unique challenges posed by the pandemic or public health emergencies in general. Existing reviews and surveys that concentrate on the applications of haptic technologies during the Covid-19 pandemic are often limited to specific domains; this survey strives to identify and consolidate all application domains discussed in the literature, including healthcare, medical training, education, social communication, and fashion and retail. Original research and review articles were collected from the Web of Science Core Collection as the main source, using a combination of keywords (like ‘haptic’, ‘haptics’, ‘touch interface’, ‘tactile’, ‘virtual reality’, ‘augmented reality’, 'Covid-19', and ‘pandemic’) and Boolean operators to refine the search and yield relevant results. The paper reviews various haptic devices and systems and discusses the technological advancements that have been made to offer more realistic and immersive VR experiences. It also addresses challenges in haptic technology in VR, including fidelity, ethical, and privacy considerations, and cost and accessibility issues.</p>

3D Multiview Holographic Display with Wide Field of View Based on Metasurface

Abstract3D display technology offers a more realistic visual experience by allowing users to perceive depth and spatial awareness, enhancing interactivity and immersion. Among various approaches, multiview display technology constructs 3D images by offering multiple smooth views along the horizontal plane. Metasurfaces, with ultra‐thin physical structures and flexible functional designs, are positioned to make significant contributions to the evolution of 3D display technologies. Here, a 3D multiview holographic display system based on metasurfaces is proposed. Using generalized Snell's law, a spatially multiplexed metasurface is designed with nine views and achieves 3D display by cascading the metasurface with a spatial light modulator (SLM). By projecting holograms onto different areas of the metasurface via the SLM, corresponding reconstructed images can be observed from specific designed directions. Thanks to the large numerical aperture (NA) of the metasurface, the system successfully achieves nine views within a 120° field of view (FOV, with a theoretical maximum of 180°), validated experimentally. This system promises potential applications in VR/AR display, surgical navigation, geographic information system (GIS), and other fields.

Enlightenment in the Learning Process? Aha Moments and Threshold Concepts as Effective Practical References in Higher Education Teaching

This paper examines the role and impact of Aha moments and Threshold Concepts in higher education, focusing on their practical implementation through a case study. Aha moments—sudden insights during learning—are pivotal in grasping complex ideas, fostering deeper understanding and motivation. The integration of real professional experiences into the curriculum is shown to enhance student motivation and improve the application of theoretical knowledge. Positive feedback highlights the effectiveness of this approach, emphasizing the importance of practice-oriented, experiential learning. The paper argues that strategically fostering Aha moments can deepen students’ grasp of Threshold Concepts, leading to greater student satisfaction and better preparation for professional challenges, while also contributing to educational quality and employability.

Narrowband Ultraviolet B Phototherapy for Generalized Granuloma Annulare: Real-Life Experience and Review of the Literature.

Generalized granuloma annulare (GA) is an uncommon noninfectious granulomatous dermatitis. Phototherapy is often considered first-line therapy, with more evidence for psoralen ultraviolet A than narrowband ultraviolet B (NB-UVB). We aimed to evaluate the effectiveness and safety of NB-UVB in generalized GA and to review the literature. In this observational, retrospective study, 11 patients with generalized GA who received NB-UVB between 2013 and 2023 were evaluated. Data from the patients were obtained from the phototherapy unit and clinical follow-up forms. Eleven patients, 10 (90.9%) female and 1 (9.1%) male were included in the study. The mean age of the patients was 57.6 ± 7.9 years. The mean disease duration was 26.9 ± 27.9 weeks. Three (27.2%) of the patients had interstitial GA. All patients showed improvement: NB-UVB therapy resulted in complete response in 18.2% of the patients and partial response in 81.8%. The mean number of NB-UVB sessions was 36.4 ± 13.8. The mean cumulative dose was 37.1 ± 25.6 J/cm2. There was no significant difference in the mean number of sessions and cumulative dose according to clinical response (P > .05). NB-UVB was extremely well tolerated. After phototherapy, patients were followed for at least 6 months; no relapses were observed. NB-UVB is an effective and safe treatment option in generalized GA.

Surrogated modelling for structural reliability and safety assessments of high-strength concrete beams with industrial and recycled steel fibers

As a secondary material recycled from tyres, Recycled Steel Fibre Reinforced Concrete (RSF) aims to replace industrial steel fibres (ISF) to improve concrete matrix‘s severability, fracture toughness, and residual tensile stress. Despite the increasing attention on the mechanical properties of this material, RSF concrete’s influence on structural component strength is still neglected due to a lack of sufficient and reliable experimental data. This study looks into existing Crack mouth opening displacement (CMOD) experiment results of both types of steel fibre reinforced concrete beams together with nonlinear finite element model (FEM) simulations using the RILEM TC 162-TDF crack damage model(CDP) proposed for ISF in ABAQUS. Meanwhile, an additional parameter analysis of the experimental data related to shear capacity also examines the shear span ratio, fibre content, and fibre type of the two types of fibre reinforced concrete beams. Moreover, Kriging surrogate models (KSM) and Sobol global sensitivity analysis have been conducted. For the reference concrete beams with a fibre content of 0.4 %, the prediction accuracy ratios of ultimate strength, corresponding displacement, and stiffness between the FEM and the experiment results are 98 %, 88 %, and 100 %, respectively. This paper has been proved that the CMOD-based CDP model effectively elucidates the shear contribution of different steel fibres, which can be used in structural analysis of ISF or RSF concrete for structure components. Utilizing FEMs, a series of modified flexural strength prediction formulas based on TR63 standards are proposed to enhance structural applications with ISF and RSF. Moreover, the prediction ability of the proposed formulas is validated using the results of 183 real flexural capacity experiments of ISF reinforced concrete beams, achieving an improved R² value of 0.97.

The place of JAK inhibitors in systemic juvenile idiopathic arthritis with lung disease (SJIA-LD): French experience.

A new form of systemic juvenile idiopathic arthritis (SJIA) with associated lung disease (SJIA-LD) has recently been described. Multiple lines of treatment have failed to yield satisfactory results for this disorder. JAK inhibitors (JAKis) have recently been approved for the treatment of JIA, but clinical evidence of their efficacy in SJIA-LD is still weak. Here we describe and assess real-life experience of SJIA-LD treatment with JAKis in France. This is a retrospective study based on information gathered from patients' medical records. Systemic and pulmonary symptoms, biological data including CRP, ferritin, IL18, chest CT scan, and functional respiratory tests were collected. Eight patients with SJIA-LD were identified in French pediatric rheumatology centers. All received at least one JAKi (baricitinib, ruxolitinib, and/or tofacitinib). Complete disease control was obtained in four patients. Steroids were tapered in four patients and stopped in two. Three patients presented an episode of MAS shortly after anti-IL1s were stopped when JAKis were introduced. Two patients had other serious side effects (viral reactivation-EBV, BK virus, cytopenia). At last follow-up, one patient had died from severe MAS, two patients had undergone hematopoietic stem cell transplantation, four were in complete response (two of them free of steroids), and one in partial response with JAKis. Lung response to JAKi was not clearly linked to disease duration. JAKis offer another therapeutic option for patients with SJIA-LD. However, the risk of MAS argues for caution about stopping anti-IL1s when introducing JAKis. Tolerance needs careful monitoring in larger studies.

Calibration of Heat Source Models in Numerical Simulations of Welding Processes

This article presents issues related to the methodology of the correct definition of the heat source model in the numerical analyses of welding processes. The problem of determining the input data for the stage of a heat source model definition, obtaining input data from experiments, and their proper interpretation and use in defining the numerical model was discussed. Particular attention is paid to the specificity of the problem of defining the heat source model, the way of interpreting the results of the analyses and the way of comparing them with the results of real experiments. The basic problems related to the mapping of the complex geometry of the molten metal pool and the ways to solve them were indicated. The solutions and guidelines presented in the article allow to improve the accuracy and quality of the obtained results of numerical analyses, as well as to shorten the time of preparation of computational models by reducing the number of computational iterations related to the search for the maximum consistency of the compared values and temperature cycles.

Construction of Virtual Experiment Teaching Platform based on 5E Teaching Mode and VI Technology

Virtual instruments have many advantages such as low cost, comprehensive functionality, easy scalability, and easy replication. At the same time, they can also meet the special requirements of time and space for remote experiments. Based on Web technology and virtual instrument technology, a virtual experiment system is constructed, which combines data sharing, remote control, and real-time operation. More conducive to utilizing experimental and scientific research resources. At the same time, virtual instruments have high flexibility and are no longer limited by traditional experimental teaching modes, which can save a lot of repeated investment costs. They can also keep the teaching equipment in the laboratory up-to-date and closely follow the development trend of science and technology. As a compulsory course for mechanical engineering majors, although the existing experimental system has achieved certain results, there are still limitations to 'Mechanical Engineering Testing Technology'. This article aims to address the problems of insufficient instrument sets and outdated equipment in the experimental teaching of "Mechanical Engineering Testing Technology", as well as students' poor ability to apply theory to practice and insufficient innovation ability. By integrating the 5E teaching mode, a virtual experimental teaching platform based on VI (Virtual Instrument) technology is established. Students can break through traditional experimental methods and conduct various experiments through the network, obtaining experimental experiences that are very similar to real experiments. At the same time, it can deepen their understanding and recognition of experiments, and better grasp theoretical knowledge.

Maintenance hemodialysis patients participate in a virtual reality rehabilitation training experience: a qualitative study

Maintenance hemodialysis patients’ psychology and physiology will have negative effects. Adherence to exercise can effectively enhance the physical function of maintenance hemodialysis patients and reduce the negative psychological emotions. In recent years, virtual reality technology has been gradually applied to the hemodialysis group, providing a new way for the rehabilitation training and healthy life of maintenance hemodialysis patients. Objectives To understand the real experience of maintenance hemodialysis patients participating in virtual reality rehabilitation training, and to make reference for the future clinical development of a more perfect virtual reality rehabilitation training program. Metchods Phenomenological research method was used to conduct semi-structured interviews with 10 maintenance hemodialysis patients, and the interview data were compiled and analyzed using Colaizzi’s seven-step analysis. Results Four themes were distilled: (1) Maintenance hemodialysis patients’ overall perceptual experience of the virtual reality rehabilitation system; (2) Physical and psychological improvement of maintenance hemodialysis patients with virtual reality rehabilitation system; (3) Individualized needs of maintenance hemodialysis patients during virtual reality rehabilitation training; (4) Future improvements and recommendations for the virtual reality rehabilitation system. Conclusion The results of the study suggest that virtual reality improves patients’ motivation to recover and shows positive results and potential benefits in improving physical functioning and negative emotions in maintenance hemodialysis patients.