The therapeutic relationships-form of the nurse-patient-relationship are formed within short durations to address patient care needs quickly and effectively, as well as psychosocial support for family or friends. The purpose of this paper is to focus on challenges that nurses can experience when trying to establish therapeutic relationships with their patients when they are in their communications due to cultural, religious or language challenges. Databases such as PubMed, Scopus, and ProQuest, were used to obtain a comprehensive overview of the literature. The synthesis of the articles grouped together to identify common patterns or themes. The data was integrated into the therapeutic relationship and its elements. The disparities between nurses and their patients may hinder nurses’ abilities to establish a therapeutic nurse-patient relationship with their Saudi patients and families. This interruption in creating such relationships may lead to a decrease in the quality of care. Effective communication seems to be associated with the intimacy of the relationship, which creates a sense of trust. A nurse’s empathy that balances power between both parties provides a perception of respect for the patients. Pre-departure education programs may help expatriate nurses learn about the culture of their hosts prior to their arrival in that country. These programs should provide opportunities for expatriate nurses to learn about, discuss and explore how to ‘fit into’ these cultural practices. Mentoring programs that electronically connect previous nurses who worked in the host country with new recruits in that country should be provided. Thus, the recruited nurses can benefit from their colleagues' experiences and have a more realistic view of what working in that host country is like. This review will help to raise leaders’ awareness about the challenges experienced by expatriate nurses who deliver care to patients with divergent belief systems than their own.