Expansion Of Zone Research Articles

Automatic Monitoring System for Hydroponic Farming: IoT-Based Design and Development

Traditional agriculture is currently facing many difficulties and obstacles. One reason is that climate change has led to a harsher environment and more pests and diseases. Also, the expansion of industrial zones has significantly reduced the arable land area. To overcome these difficulties, farmers need to change their farming methods and apply scientific and technological advances to their practice. In this paper, we report on the design and development of an automatic monitoring system for hydroponic farming based on the internet of things technique. This system allows sensor data to be collected in real time. An IoT gateway and virtual server were developed to transmit this gathered data to the cloud and store it. Via the web interface, the user can observe all the sensor data of the environment and hydroponic solution, as well as control the farming equipment. The system has been tested and evaluated during lettuce growth in an NFT hydroponic system. The experimental results show that the proposed system operates stably and achieves high reliability. The collected sensor data stored on the server can be used to analyze and evaluate the impact of environmental parameters on plant growth during cultivation.

Effect of replacing the lead core with rubber on the mechanical properties of lead rubber bearing

The expansion of earthquake zones over the past decade motivates scholars and researchers to find appropriate solutions to reduce demolishing and disaster risk. Base Isolation is one of the modern engineering solutions to dampen the earthquake force transmitted to the building. This paper estimates the effect of replacing the lead core of a lead rubber bearing (LRB) with the same size of rubber core on the mechanical properties of the seismic isolator using Finite Element Analysis (FEA). The Mooney-Rivlin was used to define the rubber hyperelastic and the Mullins effect was used to determine the rubber damage. The isolator, 700 mm in diameter with a lead core of 200 mm, using 24 rubber shims of 10 mm thickness, was simulated from a manufacturing company brochure. The shear strain of 150% was adopted with 3 hysteric loops for each model. Results presented that the rubber core increased 22% of the horizontal stiffness but decreased 5% of both horizontal force and stability. The Mullins Effect presented the rubber damage behaviour without a hysteresis loop, in which the horizontal stiffness had reduced because of rubber damage.

The 2017 Split wildfire in Croatia: evolution and the role of meteorological conditions

Abstract. The Split wildfire in July 2017, which was one of the most severe wildfires in the history of this Croatian World Heritage Site, is the focus in this study. The Split fire is a good example of a wildfire–urban interface, with unexpected fire behavior including rapid downslope spread to the coastal populated area. This study clarifies the meteorological conditions behind the fire event, those that have limited the effectiveness of firefighting operations, and the rapid escalation and expansion of the fire zones within 30 h. The Split fire propagation was first reconstructed using radio logs, interviews with firefighters and pilots involved in the intervention, eyewitness statements, digital photographs from fire detection cameras, media, and the monthly firefighting journal. Four phases of fire development have been identified. Then, weather observations and numerical simulations using an enhanced-resolution operational model are utilized to analyze the dynamics in each phase of the fire runs. The synoptic background of the event includes large surface pressure gradient between the Azores anticyclone accompanied by a cold front and a cyclone over the southeastern Balkan Peninsula. At the upper level, there was a deep shortwave trough extending from the Baltic Sea to the Adriatic Sea, which developed into a cut-off low. Such synoptic conditions have resulted in the maximum fire weather index in 2017. Combined with topography, they also locally provoke the formation of the strong northeasterly bura wind along the Adriatic coast, which has been accompanied by a low-level jet (LLJ). The bura (downslope wind), with mid- to low-level gravity-wave breaking and turbulence mixing (as in the hydraulic jump theory), also facilitated the subsidence of dry air from the upper troposphere and rapid drying at the surface. This study demonstrates that numerical guidance that indicates the spatial and temporal occurrence of a LLJ is highly capable of explaining the Split fire evolution from the ignition potential to its extinguishment stage. Thus, in addition to the conventional fire weather indices, such products are able to improve fire weather behavior forecasting and in general more effective decision-making in fire management.

Effect of advanced and injectable platelet-rich fibrins against Aggregatibacter actinomycetemcomitans in subjects with or without periodontal diseases

Background/purpose: Data for comparing effects of advanced platelet-rich fibrin (A-PRF+) and injectable platelet-rich fibrin (i-PRF) against Aggregatibacter actinomycetemcomitans (Aa) in subjects with differently periodontal conditions are scarce. This study aimed to compare the antimicrobial capacity of A-PRF+ and i-PRF obtained from subjects with or without periodontal diseases against the pathogenic bacteria Aa. Materials and methodsThe number of red blood cells, platelets, and white blood cells on the blood samples of 60 individuals, including healthy subjects (n = 20), patients with gingivitis (n = 20), and patients with periodontitis (n = 20), were analyzed before preparing A-PRF+ and i-PRF. In addition, the in vitro antibacterial effect of the two platelet concentrates was evaluated by using the agar diffusion test and a minimum inhibitory concentration (MIC) experiment. ResultsI-PRF exhibited a significantly better antibacterial effect than A-PRF+ within the gingivitis and periodontitis groups, with a more expansive zone of inhibition and a lower MIC. Among the studied groups, the A-PRF+ and i-PRF collected from the periodontitis group inhibited Aa significantly more compared with the gingivitis and healthy groups. ConclusionAlthough both A-PRF+ and i-PRF exhibited an antibacterial effect against Aa through the zone of inhibition and MIC tests, in the gingivitis and periodontitis groups, i-PRF exhibited better antibacterial activity than A-PRF+, and PRF products from the periodontitis group had greater effects against Aa than PRF products from the two other groups.

Numerical Simulation and Field Test of the Interaction between Existing Station and Enclosure in Open Excavation and Adding Stories Construction

When constructing open excavation and adding stories on the upper part of an existing station structure, the new foundation pit contacts with the existing station at zero distance; subsequently, the construction has a greater impact than that of other close constructions. To explore the cross-impact of new and existing structures on open excavation and story-adding above the existing station, in this study, through numerical simulation and field measurement, we analyze the deformation law of the existing station and foundation pit retaining structure in the excavation and story-adding construction above the existing station. The following conclusions are obtained. The excavation of the upper foundation pit leads to the overall uplift of the existing station, and the sidewall exhibits an internal extrusion trend, which is caused by an increase in the horizontal load on the station caused by the unloading of the vault and expansion of the formation plastic zone. Affected by the existing station structure, some foundation pit retaining structures are end-suspended piles; the bottoms of the end-suspended pile slips are evident. This study offers control measures for the primary support connection between the pile bottom and initial retention and protection of the existing station, deep hole grouting reinforcement of the stratum behind the pile, and reserving earth berm at the pit bottom to reduce the deformation of the end-suspended pile. The research results can provide a reference for constructing the added story of a subway transfer station.

Classification of Industrial Heat Source Objects Based on Active Fire Point Density Segmentation and Spatial Topological Correlation Analysis in the Beijing–Tianjin–Hebei Region

The development of industrial infrastructure in the Beijing–Tianjin–Hebei(BTH) region has been accompanied by a disorderly expansion of industrial zones and other inappropriate development. Accurate industrial heat source classification data become important to evaluate the policies of industrial restructuring and air quality improvement. In this study, a new classification of industrial heat source objects model based on active fire point density segmentation and spatial topological correlation analysis in the BTH Region was proposed. First, industrial heat source objects were detected with an active fire point density segmentation method using NPP-VIIRS active fire/hotspot data. Then, industrial heat source objects were classified into five categories based on a spatial topological correlation analysis method using POI data. Then, identification and classification results were manually validated based on Google Earth imagery. Finally, we evaluated the factors influencing the number of industrial heat sources based on an OLS regression model. A total of 493 industrial heat source objects were identified in this study with an identification accuracy of 96.14%(474/493). Compared with results for nighttime fires, the number of industrial heat source objects that were identified was higher, and the spatial coverage was greater; the minimum size of the detected objects was also smaller. Based on the function of the identified industrial heat source objects, the objects in the BTH region were then divided into five categories: cement plants (21.73%), steel plants (53.80%), coal and chemical industry (12.66%), oil and gas developments (7.81%), and other (4.01%). An analysis of their operations showed that the number of industrial heat source objects in operation in the BTH region tended to first rise and then decline during the 2012–2021 period, with the peak being reached in 2013. The results of this study will aid the rationalization of industrial infrastructure in the BTH region and, by extension, in China as a whole.

Site effect estimation for shallow engineering bedrock using microtremor HVSR method and geotechnical borehole data, Riyadh city, Saudi Arabia

The estimation of local site response and geotechnical properties of near-surface deposits becomes essential for improving the building codes especially in big cities as Riyadh. This study aims to estimate the site response parameters in the northern expansion zone of Riyadh city. Microtremor measurements were recorded at 45 sites at the study area, north of Riyadh, and the resonance frequency and amplification factor were calculated using the H/V spectral ratio approach. The microtremor data has been processed using geopsy software to get the H/V curve and get the value of the resonance frequency (fo) and amplitude (Ao). The values of the resonance frequency span from 0.79 to 45 Hz, while the amplification factor ranges from 1.22 to 8.5, indicating the presence of foundation bedrocks at various levels with varying soil thickness. Moreover, the N60 parameter was calculated to correct the SPT-N uncorrected field readings in order to estimate the shear wave velocity parameter down to 30 m depth (Vs30). The computed shear wave velocity for a depth of 30 m (Vs30) ranges from 210 to 630 m/s. Accordingly, the soil at the studied area can be divided into two site soil classes C and D according to the National Earthquake Hazard Reduction Program (NEHRP). The findings of this study should be considered as part of the development of the Saudi Building Code for Riyadh City.

Adhesion strength of electrodeposited Ni, Zn, and Fe coatings with copper substrates

ABSTRACT This paper presents the adhesive strength values of electrodeposited nickel, zinc, and iron coatings on copper substrates at various deposition parameters, including laser-assisted stimulation of the deposition process. One of the factors determined to be responsible for the adhesive strength of metal films with a metal substrate is the formation of a diffusion zone at the ‘coating-substrate’ interface. It is shown that an increase in adhesive strength is achieved due to the expansion of the diffusion zone and the formation of solid solutions. The decrease in adhesive strength at high overpotentials is associated with the release of hydrogen and the formation of intermediate phases.

Strain localization analysis using digital image correlation for PVA fiber-reinforced concrete-filled FRP tubes under compressive loading

This study presents the outcomes of the first experimental study on the strain localization of polyvinyl alcohol (PVA) fiber-reinforced concrete-filled fiber-reinforced polymer (FRP) tubes (CFFTs). 24 CFFT specimens were prepared and tested with various instrumentations, such as linear variable differential transformer (LVDT) and strain gauges (SGs), to record required full-field strains, i.e., axial, lateral and Von Mises strains. The strain evolutions over the surface of the specimens were recorded during axial compression loading. The FRPs were prepared with carbon, S-glass or basalt fiber to examine the influence of the fiber type and confinement stiffness on the behavior and strain localization of CFFTs. The evolution of Von Mises strains was determined and studied under axial compression. The obtained results show that although the general pattern of localization for both CFFTs without and with PVA fiber is nearly similar, the characteristics of the localization are different. The expansion of shear zone for insufficiently basalt FRP (BFRP)-confined concrete is more localized compared to the more homogenized behavior of sufficiently FRP-confined concrete. However, insufficiently BFRP-confined PVA fiber-reinforced concrete exhibits less localized behavior compared to insufficiently BFRP-confined plain concrete, which is due to the influence of the internal fibers on the concrete cracking behavior. At FRP rupture, hoop strains vary along the height and around the perimeter of the specimens, which results in the inability of SGs to consistently capture the actual hoop rupture strain.

Sanitary Sewerage Master Plan for the Sustainable Use of Wastewater on a University Campus

Wastewater collection, transport, and treatment systems are essential to ensure human and environmental well-being. The Escuela Superior Politécnica del Litoral (ESPOL), has been implementing various sanitary sewerage systems; however, population growth has given rise to discussion on the installed capacity versus the necessary capacity for the future population in the sustainable management of water resources. Therefore, this study aimed to develop a sanitary sewerage master plan by analysing the existing situation and applying technical criteria for the sustainable use of wastewater on a university campus. The methodology consisted of (i) evaluation and diagnosis of the area studied through data collection and processing, (ii) design of the sanitary sewerage system considering area-expansion zones, and (iii) SWOT analysis of a proposal to enhance wastewater transport and treatment systems. The proposal contemplates designing a sanitary sewer system that will manage the collection, transport, and treatment of wastewater over 15 years for 5667 inhabitants located in three expansion zones with occupation periods of 5, 10, and 15 years. The sewerage system comprises a pipe network 1.19 km long and 200 mm in diameter, transporting 12.37 L/s of wastewater generated to two treatment systems that guarantee efficient depuration and subsequent reuse. This design was complemented by a SWOT analysis of the existing sanitation system developed by experts in the area, which included optimising existing treatment systems and reusing wastewater for irrigation of green areas as tertiary treatment within the circular economy. The methodology used in the study allows us to offer a tool for efficiently managing wastewater on a university campus, guaranteeing human well-being, and promoting the circular economy of water.

Human Settlement Resilience Zoning and Optimizing Strategies for River-Network Cities under Flood Risk Management Objectives: Taking Yueyang City as an Example

The dense river network and large population in the southern region of China are vulnerable to flooding stress, which challenges the construction of human settlements. This paper analyzes the causes of flood risk and the dilemma of human settlement improvement in river-network cities, introduces the principle of resilience to human settlements, and conducts a quantitative study on the resilience of human settlements in river-network cities with the goal of flood risk management. Taking Yueyang city, a river-network city in the Yangtze River Basin, as the empirical research object, we conduct a flood resilience zoning of the human settlements based on the flood risk assessment model and use the GIS spatial overlay method to correct the resilience of the current human living space against the territorial spatial planning of Yueyang city. Ultimately, we propose a strategy for optimizing human settlements under flood risk management. The results show that (1) the highest-risk and high-risk areas of Yueyang city were mainly located in Dongting Lake and its interconnected water system, the southwest local area and the southeastern fringe, while the low-risk and lowest-risk areas were mainly located in the northeast local area and the northwestern fringe, with low flood stress risk. (2) The spatial system of human settlement resilience was constructed based on the flood risk assessment level. Among them, the human settlement flood resilience zoning of Yueyang city was divided into five categories from low to high: human settlement control zone, restriction zone, buffer zone, construction zone and expansion zone; the flood resilience zoning of Yueyang city’s current living space was divided into three categories from low to high: structure adjustment zone, flood restriction zone and development stability zone. (3) The specific control implementation and execution of the human settlements in Yueyang city mainly focus on the interrelationship between the risk of flooding in the watershed and the development of human activities through zoning regulation and collaborative management to optimize the human settlements. The study results can provide positive intervention and guidance for constructing urban and rural territorial spatial prevention planning and improving human living quality in river-network cities in China.

Metastable phase separation kinetics controlled by superheating and undercooling of liquid Fe-Cu peritectic alloys

The effects of superheating and undercooling on the metastable phase separation (MPS) kinetics for glass-fluxed Fe65Cu35 peritectic alloy were investigated by experiments and simulations. MPS occurred in the experimental undercooling range of 175–297 K, and induced the eccentric core-shell macrosegregation (ECSM) structure. It was first demonstrated that the relationship of the phase separation undercooling ΔTPS and the phase separation time tPS with the superheating ΔTH and the undercooling ΔT could be described by curved-surface functions. The increasing ΔTPS was observed under the smaller ΔTH or greater ΔT condition. Both the rising ΔTH and the ΔT contributed to the extension of the tPS, and then resulted in the expansion of Cu-rich zone as well as the microhardness improvement of Fe-rich zone, indicating the more thorough MPS. Numerical simulations showed that the surface segregation, Marangoni convection and Stokes sedimentation mainly pushed the evolution of the ECSM.

Nitrous oxide production in the Chesapeake Bay

AbstractEstuaries at the global scale are significant but highly uncertain sources of atmospheric nitrous oxide (N2O), which is an intense greenhouse gas and ozone depletion agent. As the largest estuary in the United States, the Chesapeake Bay is suggested to be a spatially and temporally variable source and sink of N2O. However, limited observations of N2O cycling preclude us from estimating and predicting its net N2O flux. To improve our mechanistic understanding of the processes that control the N2O flux at the point of production, we applied multiple 15N tracers (, 15N‐urea, and ) to separately track N2O production from nitrification and denitrification under in situ and manipulated O2 concentrations in the Chesapeake Bay. Nitrification was the major N2O production pathway in oxic waters (up to 7.5 nmol N2O L−1 d−1). In contrast, denitrification dominated N2O production from hypoxic/anoxic waters (up to 20 nmol N2O L−1 d−1). N2O production from urea was observed for the first time in estuarine waters. The contribution from urea was small, but interestingly, showed a depth pattern distinct from other N2O precursors. Experimentally lowering the O2 concentration substantially enhanced N2O production. Therefore, the expansion of hypoxic and anoxic zones in the Chesapeake Bay under climate change as suggested by some climate models may favor the production of N2O, potentially providing positive feedback on warming. Overall, our study provides mechanistic constraints on N2O dynamics that could benefit modeling studies to better estimate the N2O flux in the Chesapeake Bay and other coastal environments.

Spatial distribution and influencing mechanism of CO2, N2O and CH4 in the Pearl River Estuary in summer

Estuaries, considered as the important carbon dioxide (CO2), nitrous oxide (N2O) and methane (CH4) sources to the atmosphere, are increasingly affected by near-bottom hypoxia. However, the impact of estuarine hypoxic zone development on GHGs production and discharge remains poorly understood due to the seasonal and spatially distributed heterogeneity of estuarine hypoxia occurrence and the lack of simultaneous monitoring of the distribution of bottom hypoxic waters and the vertical distribution of GHGs. Here, we conducted high spatial resolution vertical stratification sampling and analysis of water column GHGs in the Pearl River Estuary (PRE), a large estuary with frequent hypoxia in recent years. Our results showed that Pearl River runoff is the main source of GHGs in the PRE. Strong nitrification is an important N2O production mechanism in the PRE. In situ generation of water and resuspension of surface sediments were the main sources of CH4 in bottom water, while massive organic matter (OM) mineralization is the main driver of CO2 in bottom water. The development of a hypoxic zone in the PRE significantly increased the concentration of N2O and CH4 in the bottom water and thus increased air-water fluxes. The air-water fluxes of N2O, CH4 and CO2 of PRE in summer were 31.9 ± 7.5 μmol m−2 d−1, 192.5 ± 229.4 μmol m−2 d−1 and 51.9 ± 14.1 mmol m−2 d−1, respectively. This study reveals that GHGs fluxes from estuarine waters to the atmosphere will increase significantly with increasing eutrophication caused by human activities and the expansion of hypoxic zones in estuarine waters.

The influence of diamond–graphite ratio on the calculation of detonation performance in VLWR

ABSTRACT For high negative oxygen balance explosives, the phase state of solid product carbon will affect the detonation performance parameters of CJ and energy release process. The description of the solid carbon by the Viral theory-based VLWR thermodynamic code only allows the selection of single-phase carbon, which does not correspond to the real physical situation. We set up a thermodynamic calculation model that gives the initial graphite/diamond ratio, and by validating the model with experimental data based on the additional graphite and RDX (C3H6O6N6) systems, we found that considering the graphitization process during isentropic expansion, the simulated data can match well with the experimental values, so the mixed-phase model we proposed can describe the more specific morphology of solid detonation product carbon. Also, based on this model, the effect of diamond/graphite ratio on the detonation performance of negative oxygen explosives TNT (C7H5O6N3), TATB (C6H6O6N6) and HNS(C14H6O12N6) was investigated, and the most probable diamond percentage was reverse calibrated by experimentally measured detonation performance parameters. The component and heat of detonation at the freeze temperature of 1500–1800 K were calculated at this ratio. Finally, the pressure P-volume V relationship for the isentropic expansion of TNT and HMX (C4H8O8N8) was calculated, the JWL equation of state (EOS) was fitted and the reduction of internal energy was calculated. The impact of the diamond/graphite ratio on the energy release of the isentropic expansion zone was investigated.

Research on Application of the Bolt-Truss Coupling Support Technology in Roadway With Water-Rich and Soft Rock

In the process of underground energy mining, the stability of roadway support is an important guarantee. In order to study the application of the anchor cable-truss support technology in water-rich soft rock roadways, the mechanical analysis of the anchor cable-truss structure is carried out, and the surrounding rock deformation of different supporting methods is numerically simulated under the consideration of the fluid–solid coupled interaction. We observed that the anchor cable (rod)-double arch truss coupling support can control the deformation of the surrounding rock and the expansion of the plastic zone well. The maximum vault subsidence of the roadway is 0.017 m, the horizontal convergence is 0.054 m, and the deformation of floor heave is 0.02 m, which are 3.8, 16.3, and 4% of the deformation under unsupported conditions, respectively; the roadway deformation is effectively controlled. The research results have certain guiding significance for the support design of the water-rich broken soft rock roadway.

Pediatric-Type Indolent B-Cell Lymphomas With Overlapping Clinical, Pathologic, and Genetic Features.

Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone lymphoma (PNMZL) are rare pediatric-type indolent B-cell lymphomas (PedIBCL) that differ clinicopathologically from their adult counterparts. Accurate diagnosis is important to avoid overtreatment but is often challenging. The mutational landscape of PTFL is known and may aid diagnosis, but the genetic features of PNMZL are not well understood. We analyzed 21 cases of PedIBCL according to their clinicopathologic findings and classified them into PTFL (n=11), PNMZL (n=2), and “mixed type” tumors (n=8) showing ambiguous histology. We also analyzed 2 cases of adult B-cell lymphomas showing features of PedIBCL. Targeted sequencing of 121 lymphoma-related genes was performed. The median age of PedIBCL patients was 16 years (range: 3 to 47), and all but 1 PTFL patient were male. All patients presented with limited-stage disease, and only 1 relapsed. There were no significant differences in clinical features among the 3 PedIBCL groups. The most frequently mutated genes were MAP2K1, TNFRSF14, KMT2C, IRF8, and NOTCH2. The genetic features of all groups were similar to the established mutational landscape of PTFL. The 2 adult B-cell lymphomas cases also had MAP2K1, TNFRSF14, and IRF8 mutations, but the clinical features were not typical of PedIBCL. In summary, this study demonstrated that PTFL and PNMZL are similar diseases with overlapping clinical, pathologic, and genetic features; mixed type tumors can also occur. Atypical adult cases with similar histologic features were also observed. Therefore, the disease spectrum of PedIBCL may be much broader than is currently believed.

Sustainable water resource management in steep-slope agriculture

Steep-slope agricultural landscapes are under threat due to climate change. On the one hand, the growing frequency of extreme high-intensity rainfall events concentrated in both temporal and spatial scales are causing flash floods or slope failure risk scenarios. On the other hand, future climate projections indicate a significant expansion of arid zones in the steep slope agricultural system. There is evidence that these landscapes face a high risk of growing water scarcity. Considering their unique role in crop production, ecosystem diversity, and crop production, ecosystem diversity, and cultural heritage, understanding sustainable water resource management for mitigating climate change-induced drought has never been more urgent than today. In these landscapes, unique indigenous knowledge of water conservation is adopted to manage water resources improving their resilience optimally. It is, therefore, necessary to promote water storage to mitigate floods or increase the resilience to prolonged drought (creating at the same time favourable conditions for biodiversity). Modern technological advances (e.g., high-resolution remote sensing and GIS-based modelling) are crucial in supporting these activities and understanding earth’s surface processes.

Prerequisites for the expansion of the range of golden grey mullet Chelon auratus (Risso, 1810) in the conditions of inconstancy of the salt regime of the northern part of the Caspian Sea

In the Caspian Sea, as in any natural body of water, the distribution and dynamics of the number of fish, including mullet, is due to the combined influence of environmental factors. In the present period of regression of the sea and changes in the level of runoff of the Volga River, salinity plays an important role in the life cycle of all representatives of the ichthyofauna. The article is devoted to the topical issue of the impact of the salt regime on the spatial and quantitative characteristics of the mullet population. The distribution and its relative abundance in 2016 and 2019 observations are presented. The distribution areas are mapped with a detailed description of the features of the formation of concentrations during two contrasting periods: desalination and salinization of the sea. Analyzing the data of trawl catches, it was found that in 2016, when the powerful Volga runoff led to the expansion of desalination zones, the average catch of mullet was 7 copies/an hour of trawling. It is noteworthy that this indicator has grown to 11 copies/an hour of trawling, during the salinization of the Northern Caspian in low-water 2019 Graphical data confirming the presence of a direct correlation between the relative abundance of mullet and increasing salinity gradients are presented. It is shown that for two years the value of the correlation coefficient was 0.74–0.76. Mullet was caught in areas with salinity from 2 to 17%. It was found that the majority of concentrations (68–74%) were formed in marine waters from 8%. In conclusion, it is concluded that the increase in salinity indicators of the northern part of the Caspian Sea has a positive effect on the expansion of the range of mullet.

Lassa fever. Part 1. Etiology, epidemiology and clinical manifestations

Lassa fever is a natural focal disease dangerous for humans. In the larger part of sub-Saharan West Africa 37.7 million people in 14 countries live in areas where living conditions are suitable for zoonotic transmission of the virus from secretions of infected rodents of the species Mastomys natalensis. Routes of transmission can be via alimentary, airborne dust or airborne droplet pathways in case of accidental human contact with secretions of infected rodents. Mastomys natalensis penetrates into residence and place of storage of food and drinking water. In addition, the residents use such animals for food, so infection is also possible upon butchering carcasses. The etiological agent of this disease is the Lassa virus being one of the members of the Arenaviridae family. Unlike other arenavirus infections (e.g., Argentine and Bolivian fevers caused by Junin viruses and Machupo, respectively), human infection with Lassa virus can also occur from person to person. Cases of nosocomial infection among patients in conditions of poor hygiene and through contaminated medical equipment are described. Medical workers become infected during surgical operations or through contact with patients, because the pathogen can be transmitted via blood, saliva, vomiting, stool or urine. In endemic territories, Lassa fever is associated with significant morbidity, because 500 thousand clinical cases and due to 5 to 10 thousand fatal outcomes of this disease are registered annually (i.e. 12% mortality). The likelihood that this disease will become a more widespread threat worldwide may be associated with increased globalization as well as climate change leading to the expansion of the Lassa fever endemic zone into regions suitable for the settlement of M. natalensis and other rodent species capable of lifelong pathogen carriage. Among hospitalized persons with severe hemorrhagic symptoms, the mortality rate can be very high ranging from 14 to 89.5%. But in the majority of cases, the disease proceeds asymptomatically, and due to its long-term incubation period all ill subjects may be a source of infection, especially travelling at long distance by plane or train. Clinically evident disease occurs in the form of various nonspecific symptoms from malaise, fever, sore throat and chest, cough, myalgia and gastrointestinal disorders to signs of central nervous system disorders. The diagnosis of Lassa fever is often difficult due to the similarity of its course with other viral diseases common in Africa or malaria or typhoid fever. More specific symptoms for Lassa fever are revealed as conjunctivitis, hepatitis, pharyngitis, tonsillitis as well as developing oropharyngeal ulcers. Severe disease is complicated by abnormal bleeding, generalized edema, respiratory failure, hypotension, proteinuria, transaminitis, encephalopathy. Deafness develops in about 20% of cases. Multiple organ failure and open bleeding lead to death. The review is devoted to analyzing publications on the etiology, epidemiology and clinical picture of Lassa fever due to a threat of its importation with sick subjects to the territory of the Russian Federation.