Background: COPD is one of the non-communicable diseases related to lung parenchyma and airways which are one of the leading causes of death and disability in India. COPD is not only considered as lung disease but also it has systematic effects that lead to co-morbidities contributing to poor performance in functional level and decreased quality of life. COPD has considerable effects in musculoskeletal system. It ranges from muscle dysfunction of respiratory system to skeletal muscle system to reduced bone density. It is also associated with decreased range of motion in cervical and thoracic region. Physiotherapy plays vital role in preventing and managing the complications in COPD patients. It has been long since exercises that consists of breathing techniques, thoracic expansion exercise and techniques to clear the secretion has been used for management of COPD. One of the emerging techniques for management of musculoskeletal dysfunctions is manual therapy. Hence current study is intended to compare the acute effects of breathing exercises and thoracic expansion exercises with high velocity low amplitude thrust.