Acute kidney injury (AKI) after liver resection remains understudied in terms of risk factors and perioperative management. Liver resection is a high-risk surgery with up to a 50% complication rate. The development of AKI is a common complication and is associated with increased mortality, morbidity, length of stay, and thus, increased costs of care. These patients present a multiplicity of risk factors that could contribute to the development of AKI, whether that be preoperative comorbidities or intraoperative factors. Consequently, the identification of such risk factors that significantly contribute to the development of AKI is important. Prevention strategies can be planned and implemented in patients at a higher risk of AKI, possibly playing an important role in providing individualised therapy in the perioperative period, and thereby improving patient outcomes. The aim of this study was to investigate and identify potential perioperative risk factors for developing AKI after liver resection. This is a retrospective analysis of a single cohort centre of 110 patients undergoing liver resection during the period of August 30, 2012 to July 27, 2016. The KDIGO criteria were used for AKI diagnosis. Pre-, intra-, and postoperative variables were manually extracted and recorded. These were then statistically analysed through univariate and multivariate regression analyses. AKI occurred in 17 patients (15.45%): 12 patients were Stage 1 AKI (70.6%), 4 patients were Stage 2 (23.5%), and 1 patient was Stage 3 (5.9%). The risk factors identified through univariate regression analysis were ASA status (P=0.023), weight (P=0.001), gender (P=0.01), and baseline serum creatinine (P=0.031). Weight and ASA status were identified in the multivariate regression analysis as being independent predictors for the development of AKI (P=0.014 and P=0.021, respectively). This study provides compelling evidence for potential risk factors in the development of AKI after liver resection. The identification of significant perioperative risk factors would allow for the refinement of existing care pathways and the development of new ones where current approaches are not fit for purpose. This would enable anaesthetists to deliver the best and most appropriate pre-, intra-, and postoperative care to meet the needs of patients who are at a greater risk of developing AKI in the liver-resection surgical setting.