The article analyzes the peculiarities of problematization of transdisciplinary experience in solving interdisciplinary and existential issues of everyday life with the involvement of scientific and value-moral priorities of scientific research. Problematization is considered comprehensively, at the level of thematization of presuppositions of transdisciplinary experience, the formation of explanatory hypotheses (by the type of abduction), taking into account not only direct but indirect evidence, using the heuristics of the thesaurus corresponding to the topic. The formation of the thesaurus is based on a cultural transfer between interdisciplinary discourses with an appeal for mutual understanding to the language of everyday communication in the mode of actual dialogue. Cultural transfer is focused on the translation and understanding of the problems discussed, the removal of speech inconsistencies, contradictions.Problematization, as a mode of conducting transdisciplinary experience, due to its complexly organized nature, does not imply unambiguous solutions once and for all. The latter circumstance plays a positive role, taking into account the chosen methodology for the real presentation of the subject of research. This experience has the ability to challenge the proposed solutions, requiring completeness, evidence, expressiveness and openness, promotes updating depending on the place and time (chronotope) of the research being conducted. Transdisciplinary experience, accumulating skills, always rechecks its methodological approaches: thematization of prerequisites and the creation of an appropriate dictionary, the formation of ways to translate interdisciplinary languages to search for explanatory hypotheses, taking into account not only direct but also indirect evidence.