Abstract: Stevens‐Johnson's syndrome (SJS) is a severe type of erythema multiforme with involvement of the mucous surfaces of the mouth, nose and conjunctiva. Although various complications have been described, reports of digestive tract lesions associated with SJS are rare. A 21‐year‐old woman developed erythematous lesions on the limbs three days after receiving antibiotic and anti‐inflammatory agent treatment for common cold‐like symptoms. On initial consultation at our hospital, endoscopy was performed to investigate the cause of a disagreeable sensation in the esophagus and mucosal exfoliation of a white membrane‐like substance was recognized as involving the entire esophagus. Sporadic white mucosal protrusions were also observed, suggesting exfoliative esophagitis. No abnormal findings were noted in the stomach or duodenum. After admission, the skin lesions rapidly expanded to involve the entire body including the mucous membranes of the lips, oral cavity, conjunctiva and vulva. Nikolsky's sign was positive. A diagnosis of SJS was made and systemic corticosteroid administration was initiated. Both the esophagitis and the skin lesions improved within 2 months of starting treatment. Esophageal lesions constitute a relatively rare manifestation of SJS, and only 10 cases have been reported in the international literature.
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Jan 1, 1998
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