Level Of Exertion Research Articles

Actual vs. perceived exertion during active virtual reality game exercise.

BackgroundVirtual exercise has become more common as emerging and converging technologies make active virtual reality games (AVRGs) a viable mode of exercise for health and fitness. Our lab has previously shown that AVRGs can elicit moderate to vigorous exercise intensities that meet recommended health benefit guidelines. Dissociative attentional focuses during AVRG gameplay have the potential to widen the gap between participants' perception of exertion and actual exertion.ObjectiveThe aim of this study was to determine actual exertion (AEx) vs. perceived exertion (PEx) levels during AVRGs by measuring heart rate (HR) and ratings of perceived exertion (RPE) in two different settings.Materials and methodsHR and RPE were collected on participants (N = 32; age 22.6 ± 2.6) during 10 min of gameplay in LabS and GymS using the HTC VIVE with the following games played: Fruit Ninja VR (FNVR), Beat Saber (BS), and Holopoint (HP).ResultsParticipants exhibited significantly higher levels of AEx compared to reported PEx for all three AVRGs (Intensity): FNVR [AEx = 11.6 ± 1.8 (Light), PEx = 9.0 ± 2.0 (Very Light)], BS [AEx = 11.3 ± 1.7 (Light), PEx = 10.3 ± 2.1 (Very Light)], HP [AEx = 13.1 ± 2.3 (Somewhat Hard), PEx = 12.3 ± 2.4 (Light–Somewhat Hard)]. Additionally, participants playing in the GymS experienced significantly higher levels of AEx [12.4 ± 2.3 (Light–Somewhat Hard)] and PEx [10.8 ± 2.5 (Very Light–Light)] compared to the LabS [AEx = 11.6 ± 1.8 (Light), PEx = 10.3 ± 2.6 (Very Light–Light)].ConclusionPerceptions of exertion may be lower than actual exertion during AVRG gameplay, and exertion levels can be influenced by the setting in which AVRGs are played. This may inform VR developers and health clinicians who aim to incorporate exercise/fitness regimens into upcoming ‘virtual worlds' currently being developed at large scales (i.e., the “metaverse”).

Lightweight neural network based model for real-time precise HR monitoring during high intensity workout using consumer smartwatches.

Mobile and wearable electronics is one of the rapidly developing areas of high technologies, which regularly appear new devices that offer new features for monitoring our health, level of physical exertion and everyday activity. From the point of view of medicine and sports, usually wearable devices are used to solve one of two tasks: round-the-clock continuous heart rate monitoring, and the control of the heart rate during workout. One of the drawbacks of such devices is the calculation errors that are caused by the motion artifacts. The most critical of them are those that arise in some cases when performing high-intensity training's, which are conjugate with intense hands movements, such as sprint running or boxing. In addition, limited resources of wearable devices do not always allow usage of very complex algorithms for processing certain events. In our work, an ultra-lightweight framework for a precise real-time heart rate monitoring during the high intensity physical exercises is developed. The model is a combination of a digital signal processing and deep convolutional and recurrent neural networks approaches. From the personalization point of view, the effect of anthropometric parameters has been studied. The model shows an average mean absolute error of 2.4±2.8 bpm during 5 fold cross-validation on an internal dataset, 2.9±3.4 bpm when evaluated on 12 IEEE SPC subjects, and 4.8±5.3 bpm when evaluated on 24 subjects from Wonkwang University dataset. Such results exceed the current state of the art solutions both in terms of the achieved accuracy of heart rate estimation and consumed computational resources. Clinical relevance- This work aims to provide a robust and lightweight neural network based framework for a real time heart rate estimation during high intensity physical exercises.

Assessment of Pain and External Load in Amputee Football Using Digital Pain Drawing and GNSS Tracking—A Pilot Study

Amputee Football (AF) players move using lofstrand crutches (LC) and a single leg during training and matches, which may expose them to excessive loads. Due to a lack of scientific articles describing these issues, this pilot study aims to gain insight into the assessment of pain experiences, as well as external loads during training and matches in AF. An observational study design was followed. Twelve male AF players (2 goalkeepers—GK and 10 field players—FP), 29.9 ± 8.7 years, stature 178.3 ± 6.5 cm, body mass 77.2 ± 8.9 kg were involved in the study. After stature and body mass measures, participants filled out the questionnaire for pain. The players were familiarized with digital pain drawing (DPD). Afterwards, they reported pain typically felt in relation to regular AF training and playing matches—recall pain (RP). During a two-day training camp (TC) with two training sessions each day and during a two-day international tournament (IT) with two matches each day, the players were monitored using DPD, rate of perceived exertion (RPE) and overall pain level (OPL) scales. In addition, during an international tournament (IT), match players were monitored using a GNSS tracking system for external load assessment. All of the participants reported multiple locations of pain after AF training or a match. The area of recall pain (RP) was the highest: +0.5% when compared to the end of TC and +43% when compared to end of IT. The pain area registered at the end of IT was significantly lower (p = 0.028) compared to RP and lower without statistical significance when compared to the end of TC. Average RPE was 3.31 ± 1.38 and average OPL was 2.86 ± 1.81 in 0–10 scale. Typical RPE was higher than that registered at the end of IT. Also typical OPL was higher compared to that registered after the end of TC, which was higher than after the end of IT. The average distance covered by a FP during a match ranged from 2483.14 ± 583.64 m to 2911.08 ± 828.90 m. AF field players suffered pain as a consequence of training and matches. The loads coming from playing and training, combined with pain, may lead to injuries. Further research directions should include assessments of the relationship of pain characteristics, injuries and GNSS tracking parameters.

EFFECTS OF POSTURAL DRAINAGE AND DEEP BREATHING EXERCISES ON DYSPNEA, OXYGEN SATURATION AND LEVEL OF EXERTION IN ELDERLY POST COVID-19 PATIENTS

Background and Aim: Elderly patients have reduced lung capacity and decrease respiratory functions due to aging process Different positioning techniques contribute in airway clearance of patients and increase in oxygen saturation level. Therefore, this study aims to find out best intervention to improve dyspnea, level of exertion and quality of life of post COVID elderly group of patients. Methodology: Study Design & Sampling technique: Randomized clinical trial and non-probability convenient sampling technique with sealed envelope Randomization. Study Setting & Participants: National Hospital and Medical Centre-DHA Lahore and 48 patients. The sample size of 48 patients was taken in this study to find the effect of postural drainage and deep breathing exercises. Patients were divided into two groups. Steam was given to both groups as a common treatment. Group A was treated with postural drainage and steam while Group B was treated with deep breathing exercises and steam. Modified Borg‘s Dyspnea, pulse oximetry and RPE scale is used for scoring. Intervention or data collection tools: Postural drainage and deep breathing exercises in 2 groups. Pulse oximetry. The Modified Borg Dyspnea Scale and Perceived exertion scale were tools. Outcome measures: oxygen level, severity of dyspnea and level of exertion. Results: Mean±S.D of patients in Postural drainage was 58.96±6.24 and in deep breathing 59.33±6.38 .pulse oximetery pre value 3.50±0.51, 3.25±0.61 in postural drainage and deep breathing respectively while post values were 1.50±0.59 and 2.25±0.68. For MBD scale pre value was 7.33±0.92, 6.92±1.14in postural drainage and deep breathing respectively while post values were 1.75±1.03and 4.84±0.82 and PES pre value was 6.87±0.81, 4.42±1.10 in postural drainage and deep breathing respectively while post values were 2.42±1.10 and 2.54±1.32 Conclusion: Postural drainage was more effective than deep breathing exercises on dyspnea, oxygen saturation and level of exertion in elderly of post covid-19 patient

Physical demands and physiological strain of American football referees while officiating

ABSTRACT Objectives Certain occupations are associated with greater risk of triggering a sudden cardiac event because of high levels of physical exertion and extreme thermal environments in which they occur. The extent to which sports officials––particularly high school (HS) American football referees––experience these conditions is unknown. Forty-six male HS officials (72% White/Caucasian; age = 48 ± 12 years, body mass index = 31.7 ± 6.6 kg·m−2) were studied to quantify the physiological strain and physical demands of officiating. Methods Referee demographics (e.g., experience, habitual exercise), pre-game urine specific gravity (USG), thermal (peak core temperature [Tcore]) and cardiovascular (average heart rate [HR]) strain, kinematic activity (e.g., total distance, speed, mechanical intensity), and environmental conditions were measured during 10 regular season varsity HS football games (≈2.5 h each) in the Southeastern United States (average wet bulb globe temperature and relative humidity: 18.9 ± 6.0 °C and 78.2% ± 12.1%). Analyses included descriptive statistics, bivariate correlations, and linear regression. Results Referees covered 5.2 ± 1.2 km per game, eliciting average HR and peak Tcore of 71.5% ± 8.0% HRmax and 38.3 ± 0.5 °C, respectively; 38% began games dehydrated (USG = 1.026 ± 0.004). Multiple regression analyses revealed that obesity (β = 0.34), not participating in regular exercise (β = −0.36), and officiating at lower mechanical intensity (β = −0.33) predicted greater cardiovascular strain (all p ≤ 0.03). White/Caucasian race/ethnicity (β = 0.59), younger age (β = −0.46), and obesity (β = 0.28) predicted greater thermal strain (all p ≤ 0.01). Conclusion HS football referees experienced elevated levels of physiological strain while officiating, with individual factors modulating the magnitude of strain. Strategies aimed at reducing obesity, increasing exercise participation, and improving cardiovascular health should be emphasized to mitigate strain and prevent cardiac events.

Relative and absolute reliability of shank and sacral running impact accelerations over a short- and long-term time frame

ABSTRACT Whilst running is hugely popular, running-related injuries (RRIs) are prevalent. High impact loading has been proposed to contribute to RRIs, with accelerometers becoming increasingly popular in estimating segmental loading for injury detection and biofeedback training. However, there is a lack of research examining the reliability of measures of impact acceleration across short- and long-term time periods, both prior to and following exerted running. The aim of this study was to assess the absolute and relative reliability of shank and sacral impact accelerations over a short- and long-term time period. Peak (Peakaccel) and rate (Rateaccel) of impact acceleration at the shank and sacrum were assessed in 18 recreational runners over short- and long-term time frames, across fixed and self-selected speeds. The relative and absolute reliabilities were investigated for pre- and post-exerted states of running. There was high-to-excellent relative reliability, and predominantly moderate absolute reliability for shank and sacrum Peakaccel and Rateaccel in the short- and long-term time frames between pre- and post-exerted states. High to excellent relative reliability of Peakaccel and Rateaccel at the shank and sacrum are appropriate and acceptable measures across short- and long-term time frames. These findings were consistent with different levels of speed and exertion. The minimal detectable change % was large for both sensors and associated measurements, indicating that their use may be limited to intervention studies that elicit large change (>30%) in these measures.

Effects of passive exoskeleton on trunk and gluteal muscle activity, spinal and hip kinematics and perceived exertion for physiotherapists in a simulated chair transfer task: A feasibility study

Despite being a topic of increasing concern, work-related musculoskeletal disorders (WMSDs) among physiotherapists, have not been comprehensively explored. This study evaluated the effects of using a passive exoskeleton on biomechanics (i.e. muscle activity of back and hip extensors) and kinematics (trunk and hip flexion angles) during a simulated chair transfer task. A simulated patient was used for the chair transfer task. Twenty working physiotherapists performed the chair transfer task with or without using a passive exoskeleton. The biomechanics and kinematics during the tasks were measured using surface electromyography (sEMG) and motion sensors, respectively. Change in exertion level was examined using the Borg CR-10 scale, and an acceptance questionnaire was adopted from previous studies and used in investigating user acceptance of the exoskeleton. Results revealed that (1) using a passive exoskeleton in performing transfer tasks significantly decreased the sEMG activities of thoracic erector spinae, lumbar erector spinae and gluteal muscles, decreasing the maximum voluntary isometric contraction by 7.78%–10.95%; (2) no significant differences in the maximal flexion angles of thoracic and lumbar spines and trunk between performing the task with and without the exoskeleton; (3) a nonsignificant decrease in exertion level when performing the transfer task with the exoskeleton; and (4) no significant between-group differences in the score of acceptance questionnaire. These findings suggested that using the exoskeleton may help alleviate loading on the back by decreasing back extensor and hip extensor muscle activities while not considerably changing sagittal plane kinematics at the trunk and hip.

Validity and reliability of a unique aerobic field test for estimating VO2max among basketball players

This study aimed at developing and validating an innovative field test for measuring the aerobic capacity of basketball players during games. Such capacity is necessary for recovering from high frequency anaerobic actions such as sprinting and continuing to perform well. To recover, the body must rebuild its creatine phosphate reserve and emit accumulated phosphate in very short periods of time. The participants included 21 male basketball players on an elite youth league in Israel, aged 16.4 years on average. In addition to participating in the proposed test (Yo-Yo Recovery Test for Basketball Players) twice (test/re-test), the players also performed three previously validated tests (Bruce Protocol Stress Test, Yo-Yo Intermittent Recovery Level 1 Test, and Yo-Yo Endurance Test). For each test, the players’ time and distance covered were documented, as were their maximum oxygen consumption and heartrate during recovery, and their perceived level of exertion. Our findings indicate the validity and reliability of the proposed aerobic field test for basketball players. Moreover, the test requires shorter times and distances for obtaining results than the other three tests. As such, this tool could be highly beneficial for basketball coaches in creating optimal training programs and game plans for each individual player and for the entire team.

Experiencing Rhythm in Dance.

In this article, two dance educators offer a definition of rhythm from both educational and performance perspectives and discuss pedagogical practices that waken students’ awareness to rhythm as a lived-experience over which they have creative control. For the dancer, in the midst of the dance, rhythms are, in the words of Margaret H’Doubler, recurring patterns of measured energy. These patterns are nested in scales from the moment-to-moment shifts in muscular contraction and release to the rise and fall of dramatic tension in a performed dance. This approach to rhythm runs counter to many dance students’ studio-based training in which rhythm is equated to synchronizing accents to a specific meter. The authors describe pedagogical practices in the studio that foster engagement with rhythm as lived-experience. Drawing attention to their kinesthetic experience while moving, students are encouraged to modulate levels of exertion embedded in the qualities of movement they are experiencing. As varying levels of exertion are attended to across temporal durations, students notice patterns as they emerge and recur. This attention to recurring patterns of measured exertion is, the authors claim, the lived-experience of rhythm in dance.

The Effect of Think Aloud on Performance and Brain Oxygenation During Cycling – An Exploratory Study

In this study, we aimed to investigate the effect of Think Aloud (TA) on performance in trained and untrained participants, using functional Near Infrared Spectroscopy, during incrementally paced cycling. A mixed design was implemented with cycling expertise (10 untrained vs. 9 trained) as the between groups variable and trial stage (5 stages of increasing effort), and condition (silent vs. TA) as within groups independent variables (IVs). Dependent measures were changes in cortical oxygenation (O2Hb) in 12 areas of the prefrontal cortex (PFC) and physiological indicators of percentage heart rate maximum (%HRmax), average power output (APO), peak power output (PPO), rate of perceived exertion (RPE) and blood lactate ([La]b) over time. Trained cyclists had higher APO and significantly higher PPO from stages 2–5, in addition to a greater increase in PPO over the duration of the test (range 168W–480 W vs. 133W–313 W). There were significant main effects of stage on %HRmax, Bla and RPE (p < .001), with effect sizes (ήp2) ranging from .31 to .97. On average, HRmax%, [La]b and RPE were significantly lower after stage 2 onwards within the TA trial than the silent trial, even though similar power outputs were obtained. Thus, the TA trial elicited a better pacing strategy. There was no main effect of group on changes in O2Hb, though O2Hb did change as a function of stage in four areas of the PFC, and as a function of condition in one area. In this first study to assess the effects of TA on performance during self-paced cycling, TA did not disrupt performance outcomes at low through to high levels of physical exertion for either untrained or trained participants.

A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results.

BackgroundExisting working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed to enable such control.MethodsSix ∼70 kg pig hearts were evaluated in vivo, then ex vivo in left‐ventricular working mode using the presented afterload. Both in vivo and ex vivo, the hearts were evaluated at two exertion levels: at rest and following a 20 μg adrenaline bolus, while measuring aortic pressure and flow, left ventricular pressure and volume, and left atrial pressure.ResultsThe afterload gave aortic pressure waveforms that matched the general shape of the in vivo measurements. A wide range of physiological systolic pressures (93 to 160 mm Hg) and diastolic pressures (73 to 113 mm Hg) were generated by the afterload.ConclusionsWith the presented afterload concept, multiple physiological loading conditions could be tested ex vivo, and compared with the corresponding in vivo data. An additional control loop from the set pressure limits to the measured systolic and diastolic aortic pressure is proposed to address discrepancies observed between the set limits and the measured pressures.

Verification of surface electromyographic activity of the oblique externus abdominis using ultrasound shear wave elastography.

This study used ultrasound shear wave elastography (SWE) to revalidate whether surface electromyographic (EMG) electrodes placed on the oblique externus abdominis (OE) can detect only the OE activity without the confounding activity of the underlying oblique internus abdominis (OI). During left and right trunk rotations, the EMG activity was acquired using surface EMG electrodes placed on the right OE. Shear wave velocity (Vs) values of the right OE and OI were acquired using SWE. The EMG activity during the left and right trunk rotations significantly increased as the level of exertion increased (25%, 50%, 75%, and 100% of the one‐repetition maximum [1RM]). The Vs of the right OE was significantly different only between 25% and 75% 1RM in the right trunk rotation, but significantly increased from 25% to 75% 1RM during the left trunk rotation. The Vs of the right OI during the right trunk rotation significantly increased with increased levels of exertion, except between 50% and 75% 1RM. The results for the Vs of the OE and OI in the right trunk rotation suggest that surface EMG electrodes placed on the OE would detect not only the antagonistic OE activity but also the agonistic OI activity.

The Effects of Blood Flow Restriction Training on Strength and Function During Early Rehabilitation After Anterior Cruciate Ligament Reconstruction in Adolescents

Background:Blood flow restriction training (BFRT) has gained popularity due to reported benefits in reducing muscle atrophy and mitigating strength deficits following anterior cruciate ligament reconstruction (ACLR). While there are a number studies that have reported on the use of BFRT in the adult population, there is limited information about the use of BFRT in the adolescent population and its effect on muscle strength and function.Hypothesis/purpose:The purpose of this study was to determine the effect of adding BFRT to traditional rehabilitation in the adolescent population after ACLR. This study’s primary aim was to investigate the impact BFRT has on isometric strength testing and patient reported function at 3 months post-operatively.Methods:A prospective intervention group was compared to an age matched retrospective control group as part of an ongoing clinical trial. This included patients between 12 and 18 years of age, who underwent primary ACLR at Connecticut Children’s from January 2020 to present. In addition to a standardized rehabilitation protocol these patients utilized a personalized tourniquet system for BFRT with limb occlusion pressure of 80%. A standardized BFRT protocol was followed over initial 12 weeks, completing 3 BFRT exercises per session. Load progression was based on the patient’s perceived level of exertion. A three month strength assessment was completed by patients in both groups. The test included isometric knee extension and flexion strength at 60° of knee flexion. Peak torque was normalized to body weight and used to calculate limb symmetry index (LSI). IKDC scores were recorded. Two-sample t tests were used to determine differences between the BFRT and control groups.Results:The BFRT group consisted of 11 patients (6 females; 14.9 ± 1.8 years old). The control group consisted of 47 patients (24 females; 15.2 ± 0.6 years old). Age, height, and weight were not significantly different between groups (Table 1). Significant differences were seen between the BFRT and control groups for peak knee extensor torque when normalized to body weight in both the surgical (1.8 ± 0.4 vs 1.4 ± 0.6 Nm/kg, p=0.02) and nonsurgical limbs (2.7 ± 0.6 vs 2.1 ± 0.5 Nm/kg, p=0.03) (Table 2). No significant differences were seen between groups for knee extensor or flexor LSI or IKDC scores (Table 2).Conclusions:In adolescents, BFRT may impact bilateral knee extensor force production during early post-operative ACLR rehabilitation. Continued investigation is needed to further evaluate the impact of BFRT in this population.Table 1.Patient DemographicsTable 2.Isometric Strength Tests and IKDC

Patient Perceptions of Exertion and Dyspnea With Interleukin-1 Blockade in Patients With Recently Decompensated Systolic Heart Failure

Interleukin-1 (IL-1) blockade is an anti-inflammatory treatment that may affect exercise capacity in heart failure (HF). We evaluated patient-reported perceptions of exertion and dyspnea at submaximal exercise during cardiopulmonary exercise testing (CPET) in a double-blind, placebo-controlled, randomized clinical trial of IL-1 blockade in patients with systolic HF (REDHART [Recently Decompensated Heart Failure Anakinra Response Trial]). Patients underwent maximal CPET at baseline, 2, 4, and 12 weeks and rated their perceived level of exertion (RPE, on a scale from 6 to 20) and dyspnea on exertion (DOE, on a scale from 0 to 10) every 3 minutes throughout exercise. Patients also answered 2 questionnaires to assess HF-related quality of life: the Duke Activity Status Index and the Minnesota Living with Heart Failure Questionnaire. From baseline to the 12-week follow-up, IL-1 blockade significantly reduced RPE and DOE at 3- and 6-minutes during CPET without changing values for heart rate, oxygen consumption, and cardiac workload at 3- and 6-minutes. Linear regression identified 6-minute RPE to be a strong independent predictor of both physical symptoms (Minnesota Living with Heart Failure Questionnaire; β = 0.474, p = 0.002) and perceived exercise capacity (Duke Activity Status Index; β = -0.443, p = 0.008). In conclusion, patient perceptions of exertion and dyspnea at submaximal exercise may be valuable surrogates for quality of life and markers of response to IL-1 blockade in patients with HF.

Relationships between perceived measures of internal load and wellness status during overseas futsal training camps.

Exercise and sport practitioners frequently utilize rating of perceived exertion (RPE) to evaluate the players' psychophysiological strains during training sessions. The subjective rating of physical exertion level during sports training has been shown to have a reciprocal relationship with wellness status during periodic training or competitive seasons. However, the relationship between subjective physical exertions and wellness status during short-term overseas training camps (OTCs) has not been extensively investigated. This study aimed to examine the perceived responses of physical exertions [session-RPE (sRPE), training monotony, and training strain] and wellness status (fatigue, sleep, delayed onset muscle soreness, stress, and mood) measures in elite young adult futsal players from four separate OTCs with different training tasks. Twenty-seven U-20 male national team futsal players voluntarily participated in this study. The players recruited for OTCs were based on their performance during domestic training camps and the tactical demand of the team. The task of each OTCs was defined as: 1) 1st OTC = game-based camp (n = 14); 2) 2nd and 3rd OTC = training-based camp (n = 20 and n = 17, respectively); and 3) 4th OTC = pre-tournament camp (n = 14). The OTCs consisted of 11 training sessions (18.9 hours) and 16 friendly matches (23.8 hours). During daily training sessions and friendly matches, sRPE was used to quantify training load (TL). Additionally, a five-elements general wellness questionnaire was used to evaluate daily wellness status in the morning. The results demonstrated that the mean and sum sRPE in the game-based OTCs were significantly lower compared to the mean sRPE [p < 0.01, effect size (ES) = -4.8; p < 0.01, ES = -2.9] and sum sRPE in the training-based OTCs (p < 0.01, ES = -3.6; p < 0.01, ES = -3.1). The mean (p = 0.01; ES = -2.0) and sum sRPE (p < 0.01; ES = -3.4) in the game-based OTC were also lower than that in the pre-tournament OTC. Conversely, the wellness scores in the game-based OTC were higher compared to the training-based (p = 0.01; ES = 1.8) and the pre-tournament OTCs (p < 0.01; ES = 1.6). There was a negative relationship between mean and sum sRPE and all wellness scores (mean sRPE = r = -0.441 ~ -0.575, p < 0.001; sum sRPE = r = -0.41 ~ -0.559, p < 0.001). Our findings suggested that responses to training sessions, derived from mean and sum sRPE and wellness scores, are dependent upon the task-specific nature of OTCs among elite futsal players. Utilization of mean and sum sRPE and wellness measures to monitor the psychophysiological health during short-term OTCs is recommended.

The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB.

This study evaluated the nephroprotective effect of kaempferol against cadmium chloride (CdCl2) -induced nephropathy in rats. It also investigated if activation of Nrf2 is a common mechanism of action. Adult male rats ((150 ± 15g) were divided into 4 groups (n = 8/each) as a control (1% DMSO, orally), control + kaempferol (200mg/kg, orally), CdCl2 (50mg/l in drinking water), and CdCl2 + kaempferol (200mg/kg)-treated rats. All treatments were conducted for 8weeks. Kaempferol significantly attenuated CdCl2-induced weight loss, reduction in kidney weights, and the injury in the glomeruli, proximal tubules, and distal tubules in the treated rats. It also significantly lowered serum levels of urea and creatinine, increased urine output and urinary creatinine levels and clearance but reduced urinary levels of albumin urinary albumin exertion (UAER), and urinary albumin/creatinine ratio (UACR) in these rats. In parallel, kaempferol downregulated renal levels of cleaved caspase-3 and Bax and unregulated those of Bcl2. In the kidney tissues of the control animals and CdCl2 rats, kaempferol significantly attenuated oxidative stress, inflammation and significantly boosted levels of manganese superoxide dismutase and glutathione. Also, and in both groups, kaempferol suppressed the nuclear levels of NF-κB p65, downregulated Keap1, and stimulated the nuclear activation and protein levels of Nrf2. In conclusion, kaempferol is a potential therapeutic drug to prevent CdCl2-induced nephropathy due to its anti-inflammatory and anti-oxidant effects mediated by suppressing NF- NF-κB p65 and transactivating Nrf2.

“Our Voices Matter”: The Learner Profile of UTech, Jamaica Students and Implications for a Virtual Self-Access Learning Centre

Since the establishment of the Self-Access Learning Centre (SALC) at the University of Technology, Jamaica (UTech, Ja.), students, particularly those enrolled in academic writing modules, have been utilising it to improve their communicative competence. However, the centre has recently encountered various challenges, chief among which are the lack of resources and restricted access to students, pushing the centre to the brink of obsolescence. This led to a revisioning of the centre, a central part of which is the creation of a virtual learner-driven SALC that focuses on the key areas in English and writing that students find challenging. For such a centre to be effective, it needs to be founded on students’ demographic, psychographic and behavioural traits. Using the results of a cross-sectional survey of 278 UTech, Ja. students, we present a learner profile of the typical student and the implications of such a profile for the creation of the virtual SALC. The results reveal that the typical student is teacher-dependent, extrinsically motivated and possesses low levels of academic exertion, low capacities for independent work and high levels of technology consumption. Based on this profile, heavy use of images, games and gamification elements, auto-rated activities, and interactive tutorials are central to the VSALC.

Echo-guided left ventricular assist device speed optimisation for exercise maximisation

ObjectiveCurrent generation left ventricular assist devices (LVADs) operate with a fixed rotation speed and no automated speed adjustment function. This study evaluates the concept of physiological pump speed optimisation based...

The Impact of Basic Police Training and Scale Diet on Body Composition and Aerobic Performance of Nepal Police Officers Trainees.

Executing their daily duties, police officers are expected to perform complex, physically demanding activities, often at maximal levels of exertion. Given these criteria, training must be rigorous enough to ensure that when trainees graduate, they are competent in their response to crisis and flexible enough to sustain this for the span of their career. The present study aimed to determine the impact of scale diet and physical training (SDPT) on body composition and aerobic performance among Nepal police officer trainees. We conducted a cross-sectional analytic study among 570 Nepal Police recruits from Nepal Police Academy of Butwal and Kathmandu. Null hypothesis was created followed by an alternative hypothesis. Alpha (1 - ?) for the above-mentioned study design were set. Parametric statistical analysis was done with criteria set for acceptance or rejection of the null hypothesis. We collected the data from the field as per Nepal police basic exercise and diet protocol to determine the effect of physical training and scale diet on body composition and aerobic performance. We enrolled all the recruits from March to May, 2019 who met the eligibility criteria in the study. We used Microsoft Excel 2013 for data entry and R program (version: 4.0.3) for statistical analysis. Results:There was a significant rise in aerobic performance (4.51 ± 3.39 ml/kg/min) and remarkable reduction in body fat (-4.49 ± 2.33 %) and Body Mass Index (-0.433 ± 1.00 kg/m2) after SDPT among participants with normal BMI at the time of recruitment. Body fat was significantly reduced (-4.36 ± 2.3%) and aerobic performance was significantly increased (6.93±4.70 ml/kg/min) among overweight participants at the time of recruitment. The methodology adopted in the physical training of Nepal Police was effective in reducing body mass index and fat, improving the physical capacity. . Key words: Scale Diet; Physical Training, Body Fat; Aerobic Performance; VO2max, Body Mass Index.

A novel multipurpose device for guided knee motion and loading during dynamic magnetic resonance imaging

IntroductionThis work aimed to develop a novel multipurpose device for guided knee flexion-extension, both passively using a motorized pneumatic system and actively (muscle-driven) with the joint unloaded or loaded during dynamic MRI. Secondary objectives were to characterize the participant experience during device use, and present preliminary dynamic MRI data to demonstrate the different device capabilities. Material and methodsSelf-reported outcomes were used to characterize the pain, physical exertion and discomfort levels experienced by 10 healthy male participants during four different active knee motion and loading protocols using the novel device. Knee angular data were recorded during the protocols to determine the maximum knee range of motion achievable. Dynamic MRI was acquired for three healthy volunteers during passive, unloaded knee motion using 2D Cartesian TSE, 2D radial GRE and 3D UTE sequences; and during active, unloaded and loaded knee motion using 2D radial GRE imaging. Because of the different MRI sequences used, spatial resolution was inherently lower for active knee motion than for passive motion acquisitions. ResultsDepending on the protocol, some participants reported slight pain, mild discomfort and varying levels of physical exertion. On average, participants achieved ∼40° of knee flexion; loaded conditions can create knee moments up to 27Nm. High quality imaging data were obtained during different motion and loading conditions. Dynamic 3D data allowed to retrospectively extract arbitrarily oriented slices. ConclusionA novel multipurpose device for guided, physiologically relevant knee motion and loading during dynamic MRI was developed. Device use was well tolerated and suitable for acquiring high quality images during different motion and loading conditions. Different bone positions between loaded and unloaded conditions were likely due to out-of-plane motion, particularly because image registration was not performed. Ultimately, this device could be used to advance our understanding of physiological and pathological joint mechanics.