ABSTRACT At present, most of the energy analysis of the engineering system is only from the energy point of view. In this paper, the theory of exergoeconomics is combined with the operation optimization of the gathering and transportation system. In terms of exergy flow distribution and the construction of each equipment, the exergy value of total 17 exergy flows and the non-energy cost of 6 main equipment in the process are calculated. An exergoeconomic model in technological process of gathering and transportation system is established. Combined with the exergoeconomic cost valuation strategy, 11 auxiliary equations are used to get the economic cost of each flow unit in the process. Taking the minimum operation exergy cost as the objective function, a mathematical model of operation optimization in exergoeconomics is established, and each decision variable is constrained on the basis of the actual site conditions. The objective function within the range of process requirements is solved by iterative method. The optimal water mixing temperature is 47.1°C, and the optimal water mixing volume is 840.7 m3/d under the actual working condition of the site in light of the calculation results.