Exercise Research Articles

Longitudinal Assessment of Sexual Behavior and Relationship Quality During the First Year of the COVID-19 Pandemic in Britain: Findings from a Longitudinal Population Survey (Natsal-COVID)

ABSTRACT While the impact of social restrictions on sexual and romantic life early in the COVID-19 pandemic has been widely studied, little is known about impacts beyond the initial months. We analyzed responses from 2,098 British adults (aged 18–59) taking part in the Natsal-COVID study (Waves 1 and 2). Participants were recruited via a web panel and surveyed twice: four months and one year after the start of the UK’s first national lockdown (July 2020 and March 2021). Changes in the prevalence and frequency of participants’ physical and virtual sexual behaviors between the two surveys were analyzed using multinomial logistic regression. Changes in the quality of intimate relationships were modeled using logistic regression for the 1,407 participants in steady relationships, adjusting for age, gender, and relationship status. The reported prevalence of any sexual activity amongst the full sample increased over the study period (from 88.1% to 91.5%, aOR = 1.50, 95% CI 1.23–1.84). Increases were observed for physical (aOR = 1.41, 95% CI 1.15–1.74) and virtual (aOR = 1.20, 95% CI 1.07–1.34) activities, particularly masturbation (aOR 1.53, 95% CI 1.37–1.72). Increases were larger for men than women. The proportion of participants in steady relationships whose relationship scored as “lower quality” increased (from 23.9% to 26.9%, aOR = 1.28, 95% CI 1.10–1.49). These findings have implications for understanding sexual health needs during disasters and planning sexual health service priorities following the pandemic.

The Analysis Study of Association of Obesity and Eczema: A Comprehensive Systematic Review

Background: Eczema is a chronic inflammatory skin condition that impacts 10% of the adult population worldwide, whereas obesity represents a significant global health issue. The relationship between eczema and obesity is intricate and differs among various populations. Mechanisms encompass eczema symptoms, avoidance of physical activity, gut microbiome influences, glucocorticoid medications, and factors related to obesity. Examining the relationship between eczema severity and related factors can guide targeted interventions and enhance comprehension of the shared pathways among these conditions. Methods: This systematic review adhered to PRISMA 2020 guidelines, focusing exclusively on full-text articles published in English between 2014 and 2024. Editorials and review articles without a DOI were excluded to ensure the utilization of high-quality sources. A literature review was conducted utilizing reputable databases including ScienceDirect, PubMed, and SagePub to identify relevant studies. Result: An initial search in databases yielded approximately 600 publications relevant to this topic. After a rigorous three-stage screening process, eight studies that met the inclusion criteria were selected for in-depth analysis. These studies underwent comprehensive critical evaluation, allowing in-depth exploration of the relationship between obesity and eczema. This systematic approach ensures that the analysis is based on high-quality evidence that is consistent with the research objectives. Conclusion: Studies demonstrate a clear correlation between moderate eczema and obesity. No significant association was discovered between severe eczema and high BMI. A higher BMI, comorbidities, and behavior may affect the association. Without a dose-response relationship, a bidirectional relationship is possible. To understand the complex association between eczema and obesity, future studies should investigate a non-linear relationship utilizing BMI as a continuous variable.

Physical activity and quality of life among breast cancer survivors: Pink SWAN

PurposeTo describe physical activity (PA) trajectories across 10 years post-breast cancer diagnosis and examine their association with quality of life (QoL).MethodsParticipants from the longitudinal Study of Women’s Health Across the Nation who developed incident breast cancer completed the Quality of Life in Adult Cancer Survivors scale (QLACS) which has 12 domains. Breast cancer survivors (BCS) with at least one post-diagnosis measure of the Kaiser Physical Activity Survey (PA) were included (n = 96). We estimated metabolic equivalents of task minutes per week (MET-min/week) for the two most frequent sport/exercise activities. Group-based trajectory modeling determined PA trajectories over 10 years post-diagnosis. Analysis of covariance assessed associations between PA trajectory group and the three QLACS domains with the worst scores (fatigue, pain, and recurrence-related distress), adjusted for PA and other relevant covariates.ResultsThere were four post-diagnosis PA trajectories: consistently very low/no PA (“inactive,” 11.5%); consistently some, but below aerobic PA guideline (“below guideline,” 48.9%); generally met aerobic PA guideline with a slight decline (“met guideline,” 22.2%); and exceeded aerobic PA guideline (“exceeded guideline,” 18.8%). In adjusted models, the below guideline group reported more fatigue than the met or exceeded groups and more pain than the met guideline group, but there were no group differences in recurrence-related distress.ConclusionThe majority of BCS did not meet the aerobic PA guideline over 10 years post diagnosis. BCS who met the aerobic PA guideline reported less fatigue and pain compared to those who did not meet the guideline in adjusted analyses, suggesting a negative association between PA and QoL.

The case of Wellness Valley: promoting physical activity and exercise medicine for a sustainable health care system

ABSTRACT Today’s health care systems primarily focus on treating noncommunicable diseases (NCDs) rather than preventing them. Currently, this approach is not sustainable and requires innovative transformations to face the challenges posed by the aging population, the increasing NCD prevalence, widespread physical inactivity, and growing obesity rates. Regular physical activity and exercise improve quality of life and are effective for the prevention and treatment of numerous NCDs and to reduce health care costs. Physical activity promotion and exercise medicine thus represent cost-effective solutions for a sustainable model of health. The Wellness Valley initiative in Emilia-Romagna, Italy, exemplifies this model by fostering active, healthy lifestyles. In Wellness Valley, physical activity is promoted through multi-stakeholder initiatives of education and engagement, and exercise medicine is supported in the medical community through continuous education and dedicated infrastructure, such as certified health-promoting gyms. With these initiatives in place, the population of Wellness Valley is more physically active compared to the Italian national average. Overall, shifting health models toward preventative strategies centered on healthy active lifestyles and exercise can increase physical activity levels and contribute to alleviating the growing burden of NCDs on health care systems.

Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity

BackgroundThe consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food consumption and depressive symptoms in Chinese populations has not been clarified. Furthermore, the factors that mediate the association between takeaway frequency and depressive symptoms are unknown.MethodsQuestionnaires were employed to collect data from 6,417 new students at Chongqing Medical University in the autumn of 2023, including sociodemographic information, takeaway frequency, physical activity levels (measured by the International Physical Activity Questionnaire Short Form), and depressive symptoms (measured by the Patient Health Questionnaire-9). Multiple linear regression and mediation analysis were performed. Multiple imputations were used to fill in missing data through sensitivity analyses.ResultsAmong 6417 participants, 2,606 (40.6%) students ordered takeaway at least once a week, with 235 (3.7%) of them ordering takeaway food every day. Takeaway frequency was significantly associated with depressive symptoms (β=0.034, P=0.006), and physical activity partially mediated this relationship (95% bootstrap confidence interval=0.0024, 0.0371).ConclusionsThe study highlights the negative relationship between takeaway frequency and emotional well-being, emphasizing the need to focus on the emotional health of frequent takeaway food consumers. Moreover, our study suggests that increased physical activity may alleviate takeaway-induced mood-related outcomes.

Review of the textbook 'Physical Activity and COVIDMOVE'

The textbook 'Physical Activity and COVIDMOVE,' edited by Dr. Dávid Líška, is an essential contribution to the field of physical health and rehabilitation. This work systematically addresses the critical role of movement, particularly in the wake of the COVID-19 pandemic. Targeted at both academic and practical audiences, the textbook provides insights into movement science, sarcopenia, mental health, and innovative rehabilitation techniques. This review will examine the book's structure, main themes, and its significance in fostering interdisciplinary collaboration. The textbook is structured into chapters that progressively build upon the role of physical activity in diverse contexts.

‘It's about collaboration’: a whole-systems approach to understanding and promoting movement in Suffolk

Abstract Background Population-levels of physical activity have remained stagnant for years. Previous approaches to modify behaviour have broadly neglected the importance of whole-systems approaches. Our research aimed to (i) understand, (ii) map, (iii) identify the leverage points, and (iv) develop solutions surrounding participation in physical activity across an English rural county. Methods A systems-consortium of partners from regional and local government, charities, providers, deliverers, advocacy groups, and health and social care, and public health engaged in our research, which consisted of two-phases. Within Phase 1, we used secondary data, insight-work, a narrative review, participatory workshops, and interviews in a pluralistic style to map the system-representing physical activity. Phase 2 began with an initial analysis using markers from social network analysis and the Action Scales Model. This analysis informed a participatory workshop, to identify leverage points, and develop solutions for change within the county. Results The systems-map is constructed from biological, financial, and psychological individual factors, interpersonal factors, systems partners, built, natural and social environmental factors, and policy and structural factors. Our initial analysis found 13 leverage points to review within our participatory workshop. When appraised by the group, (i) local governing policies, (ii) shared policies, strategies, vision, and working relationships, (iii) shared facilities (school, sport, community, recreation), and (iv) funding were deemed most important to change. Within group discussions, participants stressed the importance and challenges associated with shared working relationships, a collective vision, and strategy, the role of funding, and management of resources. Actions to leverage change included raising awareness with partners beyond the system, sharing policies, resources, insight, evidence, and capacity, and collaborating to co-produce a collective vision and strategy. Conclusions Our findings highlight the importance and provide insight into the early phase of a whole-systems approach to promoting physical activity. Our whole-systems approach within Suffolk needs to consider methods to (i) grow and maintain the systems-consortium, (ii) create a sustainable means to map the system and identify leverage points within it, and (iii) monitor and evaluate change.

The co-location of health care and leisure as part of a whole-system approach to physical activity promotion

ABSTRACT Individual-level interventions are insufficient to create the enabling conditions for population-level shifts in physical activity. This is evidenced by a lack of progress tackling physical inactivity across the globe. A more integrative and holistic approach is needed that recognizes the different contexts within which physical activity takes place. The interactions that occur between individuals and wider policy, environmental, and structural factors are also worthy of attention. This article explores an attempt to apply systems thinking and co-design to a health care context. We argue that co-locating health care clinics within leisure facilities can make it easier for people, particularly those with a health condition, to engage in physical activity.

Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and affects nearly 30% of the adult population and 10% of the pediatric population. It is estimated that this number will double by 2030. MASLD is one of the leading causes of hepatocellular carcinoma, cirrhosis, and liver transplantation, as well as a significant risk factor for cardiovascular disease and mortality. Due to the ever-increasing number of patients, the long-term asymptomatic course of the disease, serious complications, and lack of preventive programs, as well as insufficient awareness of the disease among patients and doctors themselves, MASLD is a growing interdisciplinary problem and a real challenge for modern medicine. The main cause of MASLD is an inappropriate lifestyle—inadequate nutrition and insufficient physical activity, which lead to various components of metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, and systematic physical activity—are also the basis for the prevention and treatment of MASLD. Hence, in recent years, so much importance has been attached to lifestyle medicine, to non-pharmacological treatment as prevention of lifestyle diseases. The narrative review presents possible therapeutic options for non-pharmacological management in the prevention and treatment of MASLD. The best documented and available diets used in MASLD were discussed, focusing on the benefits and drawbacks of the Mediterranean, high-protein, ketogenic, and intermittent fasting diets. In addition, the most recent recommendations regarding physical activity are summarized.

Efectividad y beneficios del ejercicio físico en pacientes con fibromialgia: una revisión bibliográfica

Introduction: Fibromyalgia is a chronic condition characterized by wides­pread pain, non-restorative sleep, fatigue, and cognitive dysfunction, which significantly affects patients’ quality of life. Material or Patients and Methods: This literature review analyzes the efficacy and benefits of physical exercise in the management of fibromyalgia, including aerobic exercises, strengthening, flexibility, aquatic activities, and specific practices like Tai Chi, yoga, and Pilates. The search was conducted in the scientific databases PubMed, Scopus, and Google Scholar. Priority was given to the inclusion of randomized clinical trials, systematic reviews, and meta-analyses. Results: Evidence demonstrates that physical exercise can reduce pain, improve functional capacity and quality of life, and decrease fatigue and stiffness. At the molecular level, physical exercise modulates inflammatory markers and neurotransmitters, contributing to the reduction of central sensitization and improving cognitive function and sleep quality. However, the response to exercise varies among patients due to the heterogeneity of the condition. Conclusion: It is crucial to design individualized and progressive exercise programs to maximize benefits and minimize the risk of exacerbating symptoms. Interdisciplinary collaboration and the integration of strategies to improve adherence are essential for deve­loping safe and effective exercise programs that enhance the quality of life for patients with fibromyalgia.

The Effect of Body Composition on Aerobic Fitness Levels and Hemodynamic Factors in Children: A Review of Literature

The benefits of physical activity (PA) are well established. However, the majority of children worldwide fail to meet the recommended weekly requirements for PA, which are essential for enhancing cardiorespiratory fitness (CRF) and maintaining a healthy weight for their age. The present review evaluated published work in an effort to study the effects of body composition on aerobic fitness levels and hemodynamic factors in children. Studies were retrieved from the following databases: Cochrane Database of Systematic Reviews, PubMed (2013-June 2024), Google Scholar, Scopus, Science Direct, EBM Reviews, Current Contents, CISTI Source (2011-June 2024), Sports Discuss (2019-June 2024), and international e-catalogues. Search analysis from these periods represents recent developments, ensuring that the review reflects up-to-date understanding in the field. This helps incorporate the latest methodologies, findings, and technological advancements, and strengthens the validity of this review. The population consists of children from both industrialized and developing nations. The selected study designs were cross-sectional, longitudinal, cohort, review, and systematic review. The analysis of research entailed reading titles, abstracts, and complete texts. Following these processes, thirty articles were considered for review. The broad investigation aims to reveal the effects of body composition on aerobic fitness levels and hemodynamic parameters in preventing childhood obesity. The search strategy, as well as Medical Subject Heading (MeSH) phrases and keywords, were used to effectively route significant papers addressing childhood obesity. The relevant terms were “body composition,” “overweight,” “obesity,” “physical activity,” “heart rate,” “blood pressure,” “aerobic fitness”, “nutrition,” “cardiovascular disease,” and “children aged 10-18 years old.” We discovered 12972 publications related to childhood obesity, hemodynamic variables, physical activity (PA), and aerobic fitness; however, 9194 articles were deleted due to duplication. The number of studies left after removing duplicates was 3778. Furthermore, 1657 articles were removed because they were not in English, 1240 articles had no full text available, and 809 articles only included abstracts. Moreover, the full text was reviewed for eligibility, which included 42 reference reviews and 18 titles. Finally, 30 articles were deemed eligible for review The existing literature suggests that additional investigation is warranted to delineate a precise course of action for mitigating the risks associated with childhood obesity. This entails placing a heightened emphasis on the significance of children engaging in aerobic fitness activities.

The Role of Lifestyle Interventions in PCOS Management: A Systematic Review

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders among reproductive-aged women. It is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Lifestyle changes are suggested as first-line interventions in managing PCOS. This systematic review aims to assess the scientific evidence regarding the role of lifestyle modifications (dietary changes, physical activity, and behavioral changes) in improving reproductive, anthropometric, metabolic, and psychological outcomes in women with PCOS. Dietary interventions such as foods with low glycemic index scores; caloric restrictions; high-fiber, omega three fatty acid-rich diets; ketogenic diets; Mediterranean diets; antioxidant-rich food; and anti-inflammatory diets improve insulin sensitivity and hormonal balance in women with PCOS. Physical activity, like aerobic and resistance exercise, enhances insulin sensitivity, helps weight loss, and improves metabolic and reproductive outcomes in women with PCOS. Further, behavioral and education modules can also be used to improve awareness, adherence, and the effectiveness of conventional treatment and to manage mental health issues related to PCOS. Collectively, lifestyle modifications not only improve the biochemical, hormonal, and anthropometric parameters in PCOS patients but also reduce the long-term risks of metabolic and cardiovascular diseases.

Impact of physical activity on respiratory diseases

Chronic respiratory diseases, including COPD, asthma, lung cancer, and COVID-19, significantly impact global health, quality of life, and healthcare systems. Physical activity is increasingly recognized for its preventive and therapeutic roles. Regular exercise enhances lung function, mitigates disease progression, and improves psychological well-being. Studies demonstrate that physical activity benefits patients with COPD, asthma, and lung cancer, promoting spirometric improvements, endurance, and post-operative recovery. Moreover, tailored exercise regimens during and after COVID-19 infection aid rehabilitation and immune resilience. Environmental considerations, such as pollution, must be addressed to maximize exercise benefits. Comprehensive pulmonary rehabilitation programs incorporating aerobic, resistance, and breathing exercises yield significant health improvements. This evidence underscores the critical role of physical activity in managing respiratory diseases, advocating its integration into patient care and public health strategies to enhance overall outcomes.

Using consumer wearables to estimate physical activity of nursing home residents with dementia

Aim: Physical activity of nursing home residents can be assessed with tools such as questionnaires and standardized fitness tests. For residents with dementia, however, those tools can be cognitively challenging and difficult to administer. Consumer wearables could potentially aid as an affordable tool for ubiquitous assessment. Methods: In this pilot study with 16 participants, we explored how measurements with an off-the-shelf wearable relate to structured observations of physical activity. We collected both processed and raw tri-axial accelerometer data from Samsung wrist-worn fitness trackers. To anchor those data in the free-living environment, we compared the measurements with the physical activity scale of the Medlo behavioral observation scheme. Results: We showed that consumer wearables are a valid tool for long-term data collection in this vulnerable patient population. Conclusions: Regarding the movement intensity, the data collected by fitness trackers is overall in accordance with the data collected with the observational tool. Regarding the type of movement, we concluded that the automatic activity classification on the wearables is not yet ready for use with a mostly sedentary patient population.

Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. Materials and Methods: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). Results: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. Conclusions: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores.

Design, Content and Ecological Validity and Reliability of the Physical Activity and Sport Habits Questionnaire for Children Aged 8–12 Years in the Province of Gipuzkoa (Spain)

Background/Objectives: This study aimed to develop a questionnaire to describe and diagnose the physical activity and sport (PAS) habits of 8–12-year-old schoolchildren, assessing its content, ecological validity and reliability, from a multidimensional perspective aligned with Global Matrix 4.0 indicators. Methods: The questionnaire design phase involved seven individuals from the university sector and sport managers from the Gipuzkoa Provincial Council. Seventeen experts later evaluated the questionnaire’s content and ecological validity. For reliability testing, 276 schoolchildren aged 8 to 12 completed the questionnaire twice, with a time interval of two weeks to two months. Statistical analyses included the Wilcoxon test to compare expert ratings, effect size and percentage change calculations for magnitude assessment, and McNemar, McN-Bowker or Wilcoxon tests to compare differences between initial and repeat responses. Cohen’s Kappa was used to assess agreement. Results: The initial battery of items, submitted to the validation process, comprised 31 items across 10 dimensions, derived from validated questionnaires and published works. Following content and ecological validity evaluations, modifications were made and nine items were removed due to improved wording, clarification of concepts, redundancy or lack of relevance. Expert quantitative analyses indicated improved overall questionnaire values. Reliability analysis revealed significant differences in five of the twenty-two items, though substantial agreement (from slight to almost perfect) was observed in twenty items. Conclusions: The study confirmed the questionnaire’s validity and reliability as a suitable tool for assessing PAS practices among 8–12-year-old schoolchildren in Gipuzkoa, Spain, in both Basque and Spanish languages.

Associations Between Adherence to the Mediterranean Diet and Incident Sarcopenia in Prospective Cohort Studies

The loss of skeletal muscle mass and strength, known as sarcopenia, is prevalent in older adults and linked to an increased risk of disability, frailty, and early mortality. Muscle health is crucial for the functionality and independence of older adults. As the aging population continuously grows, finding cost-effective strategies for preventing and treating sarcopenia is an important public health priority. While nutrition is recognized as a key factor in the development of sarcopenia, its role in preventing and treating the condition is still under investigation. In recent decades, nutritional research has shifted from a focus on individual nutrients or healthy foods to examining the combination of nutrients and foods in dietary patterns, along with their potential synergistic and antagonistic effects. A balanced diet and regular participation in physical activity are essential for maintaining musculoskeletal health. One of the healthy eating patterns with the greatest evidence of multiple health benefits is the Mediterranean diet, which has also been linked to positive effects on muscle function in observational studies. However, there is a lack of intervention studies. This review explores the updated evidence from longitudinal prospective studies on associations between adherence to the Mediterranean diet and sarcopenia in order to promote preventive and intervention strategies for healthy muscle aging.

Physical activity, Vitamin D, and all-cause/cardiovascular mortality: a prospective study in older Chinese adults

Physical activity, Vitamin D, and all-cause/cardiovascular mortality: a prospective study in older Chinese adults

Correction of postural impairments in children with relapsing-remitting multiple sclerosis

BACKGROUND: Patients with multiple sclerosis who have multifocal lesions of the central nervous system may present various complaints, including loss of balance. Some postural control disorders are detected already at an early stage of the disease. Solving this problem is critical, as it directly causes falls with subsequent injuries and deteriorating quality of life. The Balance Evaluation Systems Test offers benefits over other postural control assessment tests. It enables more personalized therapy, especially in the context of decreased tolerance to physical exercise in patients. AIM: To implement the Balance Evaluation Systems Test for a detailed assessment of postural control, identifying the markers to be used for the development of individual physical rehabilitation programs, as well as to assess the effectiveness of this approach. MATERIALS AND METHODS: This single-center, prospective, continuous, controlled, randomized study involved 38 patients from the pediatric neuropsychiatric department of a Russian children’s clinical hospital (mean age: 13–16 years). All of them had a confirmed diagnosis of relapsing-remitting multiple sclerosis. The patients were examined in the pediatric medical rehabilitation department using the Balance Evaluation Systems Test at the beginning and at the end of a therapeutic exercise course conducted on a daily basis for 10 days. The patients were randomized into two groups, 19 persons each. The control group was offered standard balance exercises; in the experimental group, exercises were selected individually for each patient, considering the identified postural control defects. RESULTS: The treatment resulted in statistically significant changes for patients both in the control and experimental groups (p 0.001). However, when comparing the results after the exercise course between the groups, the experimental group demonstrated more significant changes in postural control (p 0.001). CONCLUSION: Therefore, the Balance Evaluation Systems Test helps develop a personalized physical rehabilitation program showing more effective results. This provides patients with an opportunity to improve their functional status and reduce the risk of falls and injuries, while delaying the progression of disability and improving the quality of life.

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

Background/Objectives: Sarcopenia, characterized by the progressive loss of muscle mass and strength, is linked to physical disability, metabolic dysfunction, and an increased risk of mortality. Exercise therapy is currently acknowledged as a viable approach for addressing sarcopenia. Nevertheless, the molecular mechanisms behind exercise training or physical activity remain poorly understood. The disruption of mitochondrial homeostasis is implicated in the pathogenesis of sarcopenia. Exercise training effectively delays the onset of sarcopenia by significantly maintaining mitochondrial homeostasis, including promoting mitophagy, improving mitochondrial biogenesis, balancing mitochondrial dynamics, and maintaining mitochondrial redox. Exerkines (e.g., adipokines, myokines, hepatokines, and osteokines), signaling molecules released in response to exercise training, may potentially contribute to skeletal muscle metabolism through ameliorating mitochondrial homeostasis, reducing inflammation, and regulating protein synthesis as a defense against sarcopenia. Methods: In this review, we provide a detailed summary of exercise-induced exerkines and confer their benefit, with particular focus on their impact on mitochondrial homeostasis in the context of sarcopenia. Results: Exercise induces substantial adaptations in skeletal muscle, including increased muscle mass, improved muscle regeneration and hypertrophy, elevated hormone release, and enhanced mitochondrial function. An expanding body of research highlights that exerkines have the potential to regulate processes such as mitophagy, mitochondrial biogenesis, dynamics, autophagy, and redox balance. These mechanisms contribute to the maintenance of mitochondrial homeostasis, thereby supporting skeletal muscle metabolism and mitochondrial health. Conclusions: Through a comprehensive investigation of the molecular mechanisms within mitochondria, the context reveals new insights into the potential of exerkines as key exercise-protective sensors for combating sarcopenia.