Background: Nursing students often struggle to maintain their health due to the rigorous demands of their curriculum, which frequently involves long hours of clinical work and exposure to stressful environments. Objective: This research study sought to investigate the effectiveness of a health promotion program based on Pender's Health Promotion Model (HPM) for nursing students with chronic illnesses. Methods: The study utilized a quasi-experimental design, including 105 nursing students from several institutions—55 participants belonging to an experimental group and 50 in the control group. To determine the students' quality of well-being prior- and post-treatment/phases, researchers monitored their health behaviors utilizing the Health-Promoting Lifestyle Profile II (HPLP-II) survey tool. The program included educational activities designed around coping with chronic diseases such as nutritional counseling or exercise planning also practical tools like stress management protocols/particulars along with peer support constructs/frameworks as key components in addressing adverse effects associated with such conditions. Results: Based on the results of the paired t-tests, a significant increase in HPLP-II scores was identified after the intervention in those assigned to the experimental group. Furthermore, an independent t-test highlighted that a significant difference existed between the average HPLP-II score for experimental and control groups. Discussion: These findings were scrutinized within Pender's Health Promotion Model framework to identify which aspects of the intervention contributed most efficiently to improved health behaviors and resultant outcomes. Conclusion: This research study established compelling evidence which supports the utilization of Pender's Health Promotion Model in improving health-promoting behaviors among nursing learners with chronic ailments. This finding could help nursing educators and healthcare professionals to outline interventions for this particular demographic group.