Moderate-intensity Exercise Research Articles

Exercise Intensity Assessment of Care Farming Activities in Adults

We aimed to determine the energy expenditure, oxygen uptake, and exercise intensity of 10 care farming activities performed by adults. The study had a crossover experimental design. Participants performed 10 care farming activities for 5 minutes, including four plant- and three animal-mediated activities, and three other activities. Each participant wore a portable telemetric calorimeter during the activities, and oxygen uptake, heart rate, and exercise intensity were measured. Twenty-one adults (aged 31.5 ± 10.2 years) participated in our study. Energy expenditure, oxygen uptake, and exercise intensity differed significantly for each activity. The 10 care farming activities were regarded as light- to moderate-intensity activities. The exercise intensity, energy expenditure, and oxygen uptake for organizing a garden plot were significantly higher than those for other care farming activities. Cooking using harvests, interacting with dogs, and feeding rabbits had the lowest exercise intensity, energy expenditure, and oxygen uptake. Other activities, such as transplanting plants, harvesting, creating art, maintaining a garden, walking with a dog, and cleaning the farm, had moderate exercise intensity, energy expenditure, and oxygen uptake. Energy expenditure, oxygen uptake, and exercise intensity data could be useful when developing a care farming program suitable for the physical condition of participants in care farming interventions.

Sleep Duration Irregularity is Associated with Elevated Blood Pressure During Submaximal Exercise in Young Adults.

Irregularity in nightly sleep duration is reported to associate with elevated blood pressure (BP), but it is unclear whether this association can be observed with BP measured during exercise after controlling for factors known to influence the exercise pressor reflex. Twenty-nine young adults (22±4y; 19 men, 10 women) performed cycling exercise until volitional fatigue to assess peak oxygen uptake (VO2). Actigraphy was used to monitor sleep duration and daily physical activity for seven consecutive days after which participants completed two bouts of moderate-intensity cycling while BP and VO2 were measured using a Tango+ device and indirect calorimetry, respectively. Systolic BP was averaged from the two bouts of exercise and expressed as a change from seated rest (∆SBP). Sleep duration regularity was calculated as standard deviation (SD) and coefficient of variation (CV). Systolic BP at seated rest, during exercise, and ∆SBP was 113±13, 152±21, and 38±13 mmHg, respectively. Sleep duration SD (range 10-146 min) and sleep duration CV (range 2-54%) when excluding weekend nights were significantly correlated with ∆SBP (r = 0.58 and r = 0.62, respectively; both p<0.01) after adjusting for age, sex, body mass index, peak VO2, physical activity, resting systolic BP, chronotype, and the VO2 response to exercise. Sleep duration regularity analyzed with weekend nights included (across all seven days) was also significantly correlated with ∆SBP (p≤0.01), but had weaker correlation coefficients. These results indicate that sleep regularity, especially when excluding weekend nights, is associated with the rise in systolic BP during moderate-intensity exercise in young adults. Sleep duration regularity may be a useful tool to capture the impact of intermittent nights of insufficient sleep on BP dysregulation.

DOES EXERCISE CHANGE BLOOD FLOW TO TUMOURS? ACUTE AEROBIC EXERCISE EFFECTS ON LIVER METASTASES BLOOD FLOW: A CASE SERIES

AIM Effective cancer treatment relies on intravenous chemotherapy penetrating the entire tumour in sufficient concentrations, which is largely reliant on effective blood supply into and within the tumour. However, tumours contain abnormal vasculature with inefficient blood perfusion leading to the inability for chemotherapy to reach the target tumour. Pre-clinical evidence suggests acute exercise may increase blood flow by 200%. However, most pre-clinical studies investigate the effects of light-to-moderate intensity exercise and subsequently there is little evidence regarding the most effective exercise intensity for improved tumour vasculature. Therefore, the aim of this ongoing case series is to determine whether exercise changes tumour blood flow in a clinical model using non-invasive techniques, and how exercise intensity effects degree of change in blood flow to tumours in patients with liver metastases. METHODS Participants were eligible if they were aged over 18 years, had stage IV cancer with liver metastasis and ECOG 0-2. The study visit consisted of an aerobic fitness test (YMCA) to determine cardiorespiratory fitness and three 5-minute bouts of exercise at low, moderate and high intensities. After each exercise bout, Doppler ultrasound was used to measure a liver tumour vessel and the hepatic artery (as a control) to determine blood flow parameters. RESULTS Exercise increased peak systolic velocities (PSV) to liver tumours at all intensities compared to rest. Moderate and high exercise intensities showed a marked increase in PSV within the first 2 minutes after exercise. The hepatic artery showed less variability in PSV with time compared to the liver tumour. Cardiorespiratory fitness did not affect tumour PSV. CONCLUSION The results of this case series thus far suggest that exercise increases tumour blood flow at all exercise intensities with particular emphasis on moderate and high intensities. This supports the potential for using exercise as an adjunct to standard treatment to improve chemotherapy efficacy.

THE ACUTE EXERCISE-INDUCED INFLAMMATORY RESPONSES IN GASTROINTESTINAL DISORDERS

INTRODUCTION &amp; AIMS Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), are characterised by intestinal inflammation that presents severe symptoms and continued complications throughout the lifespan. These gastrointestinal (GI) disorders have a growing prevalence worldwide with no known cure. Management strategies often require a ‘trial and error’ process before an effective pharmacal/s is established; the successful interim varies considerably with prevalent adverse side-effects and gradual decline in the effectiveness of medication. Accordingly, alternative mechanisms to complement management options, reduce side-effects, and improve well-being warrant investigation. Physical activity is known to be beneficial for a variety of inflammatory conditions; the advantageous effects are associated with the exercise-induced inflammatory response directly from active muscle tissue. Despite this knowledge, minimal studies have attempted to quantify the inflammatory effect of exercise. This study investigates the inflammatory response of acute exercise. METHODS Participants were allocated into one of two groups: GI disorders (IBD &amp; IBS; n = 11) or apparently healthy control (AHC; n = 11). All participants completed three sessions: 1) initial familiarisation: questionnaires, anthropometry measures, DEXA scan, and a graded exercise test; 2) protocol 1: moderate-intensity continuous exercise; and 3) protocol 2: alternating high- and low-intensity exercise. Participants were randomly allocated to the acute exercise protocols. Each protocol had a fasted pre-exercise venous blood sample, 35-minutes cycle, fasted blood sample immediately post-, 2hrs post-, and 24hr post-exercise. RESULTS Significant differences were observed between groups in body mass index, waist and hip circumstances, percentage of fat mass, and VO2peak (p &amp;lt; .05). Analyses of venous blood samples will be presented. CONCLUSION With no known cure, lifestyle management is important for those with GI disorders. Exercise hosts several benefits; however, given the inflammatory nature of the condition, the acute responses of exercise are important for clinicians working with IBD/IBS patients.

RESULTS OF THE ECHO-R TRIAL – A PRAGMATIC, TELEHEALTH-DELIVERED EXERCISE INTERVENTION FOR WOMEN WITH RECURRENT OVARIAN CANCER

INTRODUCTION &amp; AIMS Wide-spread and equitable uptake of exercise into standard cancer care will require evidence of safety and efficacy across all cancer and treatment types. People with rarer cancers, lower survival prospects, and higher morbidity have been under-represented in exercise oncology trials. The ECHO-R trial for women with recurrent ovarian cancer aimed to address this research gap, evaluating the efficacy of a 6-month telephone-delivered, exercise intervention consistent with ESSA exercise oncology prescription guidelines. METHODS 50 women scheduled to receive chemotherapy for recurrent ovarian cancer were recruited to the pre-post exercise trial with assessments at baseline and post-intervention (6 months post-baseline). The intervention was delivered via 12 telephone sessions, with the option of five additional study-funded, in-person sessions with a community-based AEP. The intervention had a global target of 150 minutes of moderate-intensity multimodal exercise per week, with actual volume and prescription individualised at each session, dependent on functional capacity, goals, and barriers. Outcomes included feasibility (volume of exercise completed) and harms profile (occurrence of adverse outcomes) of the intervention, changes in patient-reported outcomes (quality of life [QoL; FACT-O], fatigue [FACT-Fatigue] and neurotoxicity [FACT-GOG-NTX]), and objective assessment of aerobic function (6-minute-walk test), muscular endurance (30-second sit-to-stand) and strength (hand grip). RESULTS The average volume of exercise completed did not meet the target (median 100 min/week, min: 0; max 527). QoL, fatigue, neurotoxicity, aerobic function, muscular endurance, and strength remained stable between the pre and post-intervention assessments. There were no serious adverse events. CONCLUSION Recurrent ovarian cancer is an incurable disease, characterised by declining QoL and physical capacity. Findings from this study suggest that maintenance of QoL and physical function is possible through participation in an exercise intervention, even if exercise targets are not met. Physical activity guidelines may need to reflect this.

EXPLORING THE EFFECTS OF VIGOROUS INTERVAL TRAINING, MODERATE RESISTANCE TRAINING AND PILATES ON ARTERIAL STIFFNESS AND BLOOD PRESSURE DURING PREGNANCY: A RANDOMISED CROSS-OVER TRIAL

INTRODUCTION Regular moderate intensity exercise throughout pregnancy provides significant benefits to both maternal and foetal cardiovascular health outcomes. Current exercise guidelines recommend a combination of moderate intensity aerobic and resistance training (RT). However, there is limited research exploring the cardiovascular effects of higher intensities (vigorous/high) in comparison to common pregnancy exercise modalities such as RT and Pilates (PIL). AIM: To investigate the acute effects of three modes of exercise (resistance, vigorous aerobic intervals and Pilates) during trimester two (T2) and three (T3) of pregnancy on measures of arterial stiffness (pulse wave velocity [PWV]) and blood pressure (BP). METHODS Eleven women with uncomplicated pregnancies (age 32 ± 3 years, pre-pregnancy BMI 23.9 ± 3.5 kg/m2) completed testing in T2 (average 20 ± 1.6 weeks gestation) and T3 (average 29 ± 2.5 weeks gestation). Participants performed one each of vigorous intensity interval training (VIIT) (∼33 min), resistance training (RT) (∼35 min) and Pilates (PIL) (∼35 min) in T2 and T3 in randomised order approximately 1 week apart each trimester. Resting outcome measures of PWV, BP and foetal heart rate (FHR) were obtained following 5 minutes of rest and again immediately and 10 minutes post exercise session. BP, maternal heart rate (MHR), and rating of perceived exertion (RPE) were monitored throughout. RESULTS There was no difference in the acute PWV response to each type of exercise across the trimesters (1 min VIIT: T2 = 5.53 ± 0.85m/s, T3 = 5.26 ± 0.67m/s, 95%CI[-1.36-0.67]; RT: T2 = 5.4 ± 0.80m/s, T3 = 5.48 ± 0.56m/s, 95%CI[-0.88-1.10]; PIL: T2 = 5.44 ± 0.68m/s, T3 = 5.44 ± 0.68m/s, 95%CI[-0.93-1.01]). There was no significant difference in the acute response in SBP to VIIT (T2 = 116 ± 12.1mmHg, T3 = 122 ± 7.2mmHg, 95%CI[-0.42 - 1.65]. SBP was significantly higher in T3 than T2 1 minute following PIL (T2 = 110 ± 5.8mmHg, T3 = 121 ± 11.7mmHg, 95%CI[0.04-2.1]) and 10 minutes following RT (T2 = 105 ± 10.1mmHg, T3 = 116 ± 5.0mmHg, 95%CI[0.27 - 2.46]. CONCLUSION VIIT, RT and PIL appear to elicit similar post-exercise haemodynamic and arterial stiffness responses in both the mother and foetus. As such, VIIT may be a suitable addition to standard moderate intensity and RT prescription during an uncomplicated pregnancy.

Can just 15 minutes of moderate-intensity exercise mobilize cytotoxic NK cells into circulation?

Intro: Acute exercise transiently mobilizes natural killer (NK) cells into the bloodstream with the degree of mobilization directly related to the intensity of the exercise. This increase in NK cells is thought to offer a period of heightened immune activity during exercise and is of particular interest to cancer patients as NK cells can kill tumor cells without prior sensitization. Previous work demonstrating the benefits of exercise on NK cells used vigorous bouts of exercise lasting 30 minutes or longer, which may not be attainable for cancer patients. The objective of this study was to determine whether a short bout of moderate-intensity exercise can mobilize activated, cytotoxic NK cells into circulation. We hypothesized that i) a bout of moderate-intensity exercise would significantly increase NK cells in the blood and ii) the exercise-induced NK-cell mobilization would occur rapidly, such that the relative increase in blood NK cells would not differ after 15 minutes of exercise and 30 minutes of exercise. Methods: In this pilot study, ten healthy, non-athletes (4 female; aged 18-40 years) cycled for 30 minutes at 55% of their heart rate reserve. Venous blood was obtained pre-, after 15 minutes, and after 30 minutes of exercise, and was analyzed by flow cytometry. The proportion of NK cells, CD16+ and CD57+ NK-cells were compared between the three time points by repeated measures ANOVA with Greenhouse Geisser corrections. Sidak-corrected post-hoc tests were used to further analyze significant main effects. Results: All subjects successfully completed the exercise (mean ± standard deviation heart rate: 144 ± 2 bpm; rating of perceived exertion: 11 ± 0.25 (of 20)). There was a significant main effect of time on the proportion of NK cells present in the blood (F(1.253, 10.025)= 7.719, p= 0.016). Post-hoc analyses indicate that there was a significant increase at minute 15 relative to baseline (p=.050), with no further increase at minute 30 relative to minute 15 (p=.175). There was no main effect of time on the proportion of CD57+NK cells (F(1.451, 10.159)= 0.335, p= 0.656) or CD16+ NK cells (F(1.154, 9.231)= 3.020, p= 0.113) in our sample. Conclusion: The results from this pilot study indicate that 15 minutes of moderate-intensity cycling mobilizes NK cells into the bloodstream. However, we did not detect significant differences in NK cells with an activated, highly cytotoxic phenotype. While limited by a small sample, these results build upon prior work demonstrating a significant effect of longer-lasting, vigorous-intensity exercise. The current results suggest that a more accessible exercise intervention for individuals with health limitations can also significantly increase NK cells into the blood, but that greater intensity exercise may be required to mobilize particular subsets of NK cells. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

High-Intensity Gait Training in an Individual With Neuromyelitis Optica and Research Recommendations for Individuals With Multiple Sclerosis.

Neuromyelitis optica (NMO), similar to multiple sclerosis (MS), is an autoimmune disorder affecting the central nervous system. In people with central nervous system diagnoses, high-intensity gait training (HIGT) can support neuroplasticity, improving functional mobility. While low- to moderate-intensity exercise is beneficial in improving outcomes in individuals with NMO and MS, the impact of HIGT has not been thoroughly explored. This case study explores the safety and efficacy of HIGT in an individual with NMO. A 43-year-old man with NMO participated in a HIGT program utilizing the least amount of body weight support necessary to achieve a target heart rate of 60% to 80% of heart rate reserve or a Borg Rating of Perceived Exertion score of 15 to 17 during an in-patient rehabilitation stay. Interventions incorporated stair training, gait variances, and virtual reality. The patient successfully completed a 90-minute training session 4 to 7 times per week for 6 weeks following a HIGT regimen for 40% to 60% of each session. Meaningful gains in bed mobility, transfers, and gait allowed for discharge to his home. This case suggests that HIGT in patients with NMO can be safe and effective in improving functional mobility. Due to the similarities between NMO and MS, this case provides a framework to assist clinicians in developing a HIGT plan of care for individuals with MS. Additional research is needed to clarify HIGT parameters, including intensity and duration, to improve functional mobility in individuals with MS.

The Evaluation of Physiopathological and Immunological Exercise Effects During Pandemic and Pathogenicity on Coronavirus COVID-19 (with Considerations and Instructions of Doing Related Physical Activity)

Context: The 2019 coronavirus disease (COVID-19), also commonly known as the coronavirus, is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is associated with several challenges, including an increased sedentary lifestyle, obesity, and elevated inflammatory factors and related diseases. Evidence Acquisition: In conducting this research, we utilized the latest articles from prestigious domestic and foreign journals indexed in databases such as PubMed, Google Scholar, and ScienceDirect. Results: There are various hypotheses regarding the intensity of exercise and its impact on infection rates. Moderate-intensity exercise is believed to enhance immune function and reduce mortality, whereas high-intensity and stressful exercise may have the opposite effect. When exposed to infection, high-intensity exercise can suppress the immune system, whereas moderate-intensity exercise may reduce inflammation. Conclusions: Therefore, given that exercise affects the strength and anti-inflammatory mechanisms of the immune system, it plays a crucial role in reducing complications for patients. Consequently, it can be concluded that exercise strengthens the immune system, reduces inflammation, and creates favorable physiological and immunological conditions to aid athletes in overcoming the virus.

Effects of 12 Weeks of Moderate-intensity Continuous Exercise and High-intensity Interval Exercise on Cognitive Function in Elderly Subjects

OBJECTIVES This study analyzed the possibility of brain function activation after exercise training of high-intensity interval exercise and moderate-intensity continuous exercise in elderly people.METHODS The subjects of the study were elderly female people aged 65 years or older and were divided into three groups : control group, moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT). Changes of body composition, physical fitness, cognitive function, and cognitive function-related blood variables were compared between before and after 12 weeks of exercise training.RESULTS Body weight, BMI (body mass index), and WHR (waist hip ratio) of body composition in HIIT group decreased significantly (p&lt;0.05) after exercise training, and there was no significant difference in MICT group and the control group. HIIT group significantly (p&lt;0.05) improved in grip strength, muscular endurance, flexibility, balance, cardiorespiratory endurance, and walking ability after exercise training, while MICT group showed significant (p&lt;0.05) improvements only in flexibility, balance, and cardiorespiratory endurance. Regarding blood variables, HIIT group showed significant (p&lt;0.05) differences in BDNF (brain-derived neurotrophic factor), irisin, and β-amyloid after exercise training, MICT group showed significant (p&lt;0.05) differences only in β-amyloid. Cognitive function in HIIT group and MICT group significantly (p&lt;0.05) improved in terms of temporal and spatial orientation, memory, and total scores after exercise training. During the recovery phase after one session of high-intensity interval exercise, blood lactic acid concentration increased significantly.CONCLUSIONS This study was confirmed the possibility of giving that high-intensity interval exercise for the elderly not only produces positive changes in body composition and improves physical fitness and cognitive function, but also frequently stimulates lactate production, helping to activate brain function through changes in BDNF and irisin in the blood.

The consequence of 12 weeks of Pilates exercise on the quality of sleep and life of pregnant women

Aim: As one of the most critical periods in women's lives, pregnancy affects their physical, mental, and functional conditions. These changes can affect the quality of life and sleep of pregnant women. The main purpose of this study is to investigate the effect of Pilates exercises on 140 young pregnant women between the ages of 20-40. Methods: This randomized double-blind clinical trial study was done between September 2023 and March 2024, including 60 pregnant women in case group and 90 control subjects of similar age and body mass index (BMI). This study investigated the effect of 12 weeks of pilates exercises on the quality of women's sleep and life. Quality of life was measured by the short-form 36 (SF-36) and quality of sleep by the Pittsburgh Sleep Quality Index (PSQI). People were randomly divided into intervention and control groups. Pregnant women in the intervention group were required to participate in two pilates sessions per week for 12 weeks from the 20th week of pregnancy. Results: Our results found that quality of life levels were statistically significant higher than case group after intervention compared to control group (p&lt;0.05; 67.19 vs. 54.94). Also, a statistically significant association between the case and control regarding quality of sleep (p&lt;0.05; 5.41 vs. 6.77). Conclusion: It is concluded that performing moderate-intensity pilates exercises for 12 weeks in the last months of pregnancy can increase sleep quality and life.

Exercise perspective: Benefits and mechanisms of gut microbiota on the body.

Gut microbiota refers to the vast and diverse community of microorganisms residing in the intestines. Factors such as genetics, environmental influences (e.g., exercise, diet), and early life experiences (e.g., infant feeding methods) can all affect the ecological balance of gut microbiota within the body. Dysbiosis of the gut microbiota is associated with extra-intestinal diseases such as Parkinson's syndrome, osteoporosis, and autoimmune diseases, suggesting that disturbances in gut microbiota may be one of the causes of these diseases. Exercise benefits various diseases, with gut microbiota playing a role in regulating the nervous, musculoskeletal, and immune systems. Gut microbiota can impact the body's health status through the gut-brain axis, gut-muscle axis, and immune pathways. Moderate-intensity aerobic exercise can increase the quantity of gut microbiota and change microbial abundance, although short-term exercise does not significantly affect the alpha diversity of the microbiota. Resistance exercise also does not have a significant regulatory effect on gut microbiota.

Effects of conventional versus virtual reality-simulated treadmill exercise on fatigue, cognitive function, and participant satisfaction in post-COVID-19 subjects. A randomized trial

Background/ObjectivePost-COVID-19 subjects typically experience symptoms of fatigue, cognitive impairment, and sleep difficulty, which can be relieved by conventional aerobic exercise. Virtual Reality (VR) technology to support conventional exercise has recently gained much attention. Therefore, this study aimed to assess the effects of traditional treadmill exercise compared to virtual reality-simulated treadmill exercise on fatigue, cognitive function, sleep quality, and participant satisfaction with the exercise program in post-COVID-19 subjects. MethodsThis single-centered, randomized, parallel-group intervention study was conducted between December 2021 and March 2022. Sixteen of twenty post-COVID-19 subjects completed this study (n1 = 8, n2 = 8). Inclusion criteria were persistent dyspnea/fatigue, mild cognitive problems, and age from 30–60 years. Exclusion criteria were previous severe COVID-19 infection and ICU admission, concomitant respiratory or cardiovascular disease, and musculoskeletal or neurological disease. Eligible subjects were assigned randomly to two groups: a non-VR group that received traditional treadmill aerobic exercise only and a VR group that received treadmill exercise with non-immersive VR. Both groups received moderate-intensity exercise on a treadmill at [50–60 % (peak HR－resting HR) + resting HR] for 30–45 min, three times per week, and for four weeks. The outcome measures were the Chalder Fatigue Scale, Montreal Cognitive Assessment (MoCA) questionnaire, Pittsburgh Sleep Quality Index (PSQI), and participant satisfaction with the exercise program rated on a 5-point Likert scale. ResultsBoth groups showed significant improvements in the Chalder Fatigue Scale, the MoCA questionnaire, and the PSQI scores after training compared to baseline (p < 0.05), without significant differences between them (p > 0.05). However, participant satisfaction with the exercise program was significantly higher in the VR group than in the non-VR group (p = 0.037). ConclusionA moderate-intensity 4-week treadmill exercise program with and without non-immersive VR may improve fatigue, cognitive function, and sleep quality to the same extent in COVID-19 survivors. However, participant satisfaction with the exercise program could be greater after conventional treadmill training assisted by non-immersive VR than after conventional treadmill training alone in this cohort. Trial registrationPan African Clinical Trials Registry, PACTR202311561948428, retrospectively registered.

P069 Moving more with Axial Spondyloarthritis - a short survey to help design future exercise studies

Abstract Background/Aims Axial Spondyloarthritis (AxSpA) is an inflammatory arthritis affecting 0.5-1.0% of people in the UK. Physical activity guidance for people living with AxSpA from the National Institute for Health and Care Excellence is vague. Individualised, structured aerobic exercise is recommended without any direction towards exercise type, frequency, intensity, or acknowledgement of physical limitations to an individual’s environment which may prevent exercise participation. Consequently, the proportion of people with AxSpA meeting the World Health Organisation physical activity recommendations (&amp;gt;150 minutes of moderate-intensity exercise per week) is significantly lower than the general population. Therefore, a short survey was administered to people with AxSpA to understand types of physical activities they would like to participate in, and any common barriers to exercise participation. Methods The National Axial Spondyloarthritis Society (NASS) invited subscribers to their e-newsletter with lived experience to complete a short online survey. Respondents were asked ‘which of the following activities would you like to include as part of your usual lifestyle?’ ‘What would prevent you from taking part in the activities above?’ and ‘Do you already include any of the physical activities in your usual lifestyle?’ Respondents were allowed to choose multiple options from a range of activities and barriers. Results 266 people living with AxSpA (68% women, 31% men, 1% non-binary, 94% white British/Irish) responded. Walking was most selected for activities respondents would like to be included as part of their lifestyle (83%), followed by stretching/flexibility exercises (61%), swimming (46%), weight training and resistance exercise (41%), and cycling (33%). Only eight respondents (3%) stated hydrotherapy which is traditionally advocated as exercise therapy in AxSpA. Worries about pain and flare ups (57%), fatigue (45%), time (39%), cost (27%), not knowing enough about how much activity to do (22%), and lack of available facilities (20%) were common barriers. Conclusion To maximise reach and benefit, exercise guidance needs to relate to exercise that people with AxSpA would like to or already do; the benefits of exercise can only be realised if people want to participate. The responses emphasise the need for guidance relating to inclusive models of exercise. This includes exercise such as walking that is flexible and adaptable to limitations of time and does not require additional cost, equipment, or facilities. The results also highlight the importance of including outcome assessments of pain, flare frequency, and fatigue. Disclosure M. Roberts: None. S. Qooja: None. A. Moorthy: Consultancies; AM has received speaker fees from Lilly, Novartis, Galapagos, and UCB. L. Bishop: Grants/research support; NCB has received funding from NASS..

Low- and moderate-intensity aerobic exercise improves the physiological acclimatization of lowlanders on the Tibetan plateau.

This study investigates whether exercise as a strategy for improving physical fitness at sea level also offers comparable benefits in the unique context of high altitudes (HA), considering the physiological challenges of hypoxic conditions. Overall, 121 lowlanders who had lived on the Tibetan Plateau for >2years and were still living at HA during the measurements were randomly classified into four groups. Each individual of the low-intensity (LI), moderate-intensity (MI), and high-intensity (HI) groups performed 20 sessions of aerobic exercise at HA (3680m) over 4weeks, while the control group (CG) did not undergo any intervention. Physiological responses before and after the intervention were observed. The LI and MI groups experienced significant improvement in cardiopulmonary fitness (0.27 and 0.35L/min increases in peak oxygen uptake [ O2peak], both p<0.05) after exercise intervention, while the hematocrit (HCT) remained unchanged (p>0.05). However, HI exercise was less efficient for cardiopulmonary fitness of lowlanders (0.02L/min decrease in O2peak, p>0.05), whereas both the HCT (1.74 %, p<0.001) and glomerular filtration rate (18.41mL/min, p<0.001) increased with HI intervention. Therefore, LI and MI aerobic exercise, rather than HI, can help lowlanders in Tibet become more acclimated to the HA by increasing cardiopulmonary function and counteracting erythrocytosis.

Changes in High-Sensitivity C-Reactive Protein Levels After Two-Weeks of Moderate-Intensity Endurance Exercise in Obese Women

Study purpose. The study purpose was to analyze the effect of moderate-intensity endurance exercise on reducing inflammation in obese women. Materials and methods. Twenty obese women selected according to the established criteria were used as subjects. Then the subjects were divided into two groups: the control group (G1) and the endurance exercise group (G2). Moderate-intensity endurance exercise was performed by running on a treadmill for 40 minutes, with a frequency of 5 times/week for 2 weeks. Moderate-intensity was performed with 60%-70% HRmax (HRmax formula: 220-age). Blood sampling for inflammation measurement using the biomarker High-sensitivity C-reactive protein (hs-CRP) was performed before and after the intervention for 2 weeks. hs-CRP was measured using the enzyme-linked immunosorbent assay (ELISA) method. A paired sample t-test with a significant level (p ≤ 0.05) was used for data analysis. Results. The results showed the mean hs-CRP levels between before and after the intervention in G1 (6.76±4.40 vs. 6.43±4.89 ng/mL, (p=0.641)) and G2 (6.56±3.34 vs. 2.12±1.14 ng/mL, (p=0.004)). Conclusions. The study indicates that moderate-intensity endurance exercise has been shown to be effective in reducing inflammation levels in obese women, so individuals with obesity are advised to reduce inflammation levels through moderate-intensity endurance exercise.

Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development, as evidenced by the ability to increase bone density and peak bone mass by promoting bone formation. AIM To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying mechanisms. METHODS 20 growing mice were randomly divided into two groups: Con group (control group, n = 10) and Ex group (treadmill exercise group, n = 10). Hematoxylin-eosin staining, immunohistochemistry, and micro-CT scanning were used to assess the bone formation-related indexes of the mouse femur. Bioinformatics analysis was used to find potential miRNAs targets of long non-coding RNA H19 (lncRNA H19). RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic differentiation. RESULTS Compared with the Con group, the expression of bone morphogenetic protein 2 was also significantly increased. The micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density, bone volume fraction, and the number of trabeculae, and decreased trabecular segregation in the femur of mice. Inhibition of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic differentiation. In addition, knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers, which is consistent with the results of autophagy-related protein changes detected in mouse femurs by immunofluorescence. CONCLUSION Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice, thus enhancing the peak bone mass of mice. The lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

Accurate Prediction Equations for Ventilatory Thresholds in Cardiometabolic Disease When Gas Exchange Analysis is Unavailable: Development and Validation.

To develop and validate equations predicting heart rate (HR) at the first and second ventilatory thresholds (VTs) and an optimized range-adjusted prescription for patients with cardiometabolic disease (CMD). To compare their performance against guideline-based exercise intensity domains. Cross-sectional study involving 2,868 CMD patients from nine countries. HR predictive equations for first and second VTs (VT1, VT2) were developed using multivariate linear regression with 975 cycle-ergometer cardiopulmonary exercise tests (CPET). 'Adjusted' percentages of peak HR (%HRpeak) and HR reserve (%HRR) were derived from this group. External validation with 1,893 CPET (cycle-ergometer or treadmill) assessed accuracy, agreement, and reliability against guideline-based %HRpeak and %HRR prescriptions using mean absolute percentage error (MAPE), Bland-Altman analyses, intraclass correlation coefficients (ICC). HR predictive equations (R²: 0.77 VT1, 0.88 VT2) and adjusted %HRR (VT1: 42%, VT2: 77%) were developed. External validation demonstrated superiority over widely used guideline-directed intensity domains for %HRpeak and %HRR. The new methods showed consistent performance across both VTs with lower MAPE (VT1: 7.1%, VT2: 5.0%), 'good' ICC for VT1 (0.81, 0.82) and 'excellent' for VT2 (0.93). Guideline-based exercise intensity domains had higher MAPE (VT1: 6.8%-21.3%, VT2: 5.1%-16.7%), 'poor' to 'good' ICC for VT1, and 'poor' to 'excellent' for VT2, indicating inconsistencies related to specific VTs across guidelines. Developed and validated HR predictive equations and the optimized %HRR for CMD patients for determining VT1 and VT2 outperformed the guideline-based exercise intensity domains and showed ergometer interchangeability. They offer a superior alternative for prescribing moderate intensity exercise when CPET is unavailable.

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

IntroductionSupervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and...

The Effect of Different Exercise Modalities on Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced Obesity Rat Models: Implication on Glucose and Lactate Transport, Igf1, and Igf1R-dependent Pathways.

The study aimed to uncover a unique aspect of obesity-related metabolic disorders in the testicles induced by a high-fat diet (HFD) and explored the potential mitigating effects of exercise modalities on male fertility. Thirty mature male Wistar rats were randomly assigned to control, HFD-sole, moderate-intensity exercise with HFD (HFD+MICT), high-intensity continuous exercise with HFD (HFD+HICT), and high-intensity interval exercise with HFD (HFD+HIIT) groups (n=6/group). Intracytoplasmic carbohydrate (ICC) storage, expression levels of GLUT-1, GLUT-3, MCT-4, Igf1, and Igf1R, and testicular lactate and lactate dehydrogenase (LDH) levels were assessed. ICC storage significantly decreased in HFD-sole rats, along with decreased mRNA and protein levels of GLUT-1, GLUT-3, MCT-4, Igf1, and Igf1R. The HFD-sole group exhibited a notable reduction in testicular lactate and LDH levels (p<0.05). Conversely, exercise, particularly HIIT, upregulated ICC storage, expression levels of GLUT-1, GLUT-3, MCT-4, Igf1, and Igf1R, and enhanced testicular lactate and LDH levels. These results confirm that exercise, especially HIIT, has the potential to mitigate the adverse effects of HFD-induced obesity on testicular metabolism and male fertility. The upregulation of metabolite transporters, LDH, lactate levels, Igf1, and Igf1R expression may contribute to maintaining metabolic interactions and improving the glucose/lactate conversion process. These findings underscore the potential benefits of exercise in preventing and managing obesity-related male fertility issues.