Previous studies have reported that slower VO2 kinetics typically observed in healthy older individuals can be prevented by long-term endurance training interventions. However, the chronic adaptations on the VO2 kinetics and muscle deoxygenation ([HHb]) kinetics response in trained older adults with coronary artery disease (CAD) remains unknown. PURPOSE: to compare VO2 and [HHb] kinetics response in moderate exercise in older adults with CAD and a control group (CG) of healthy active age- and gender-matched individuals. Both groups did at least 6 months the following exercise training (ET) prescription, 3 d.wk-1 x 60-min: 30 min at 60-70% heart rate reserve + 2 x 8-12 repetitions in 6 major muscle groups. METHODS: thirty-two male participants (age: 63.5 ± 8.3 years; n= 17 CAD and n=15 CG) completed the following assessments: 1) incremental symptom-limited cycling cardiopulmonary exercise test; 2) square-wave transitions from rest to moderate-intensity exercise. Pulmonary VO2 was collected breath-by-breath and [HHb] data of the vastus lateralis was determined by near-infrared spectroscopy. The parameters of the VO2 and [HHb] kinetics were determined using a monoexponential model. Differences between groups was assessed with the independent-samples t-test. RESULTS: Peak oxygen consumption and peak work load were lower in CAD compared to CG (CAD: 23.2 ± 6.2, CG: 30.4 ± 7.5 ml/kg/min, p<0.05; and CAD: 158 ± 47, CG: 193 ± 50 W, p<0.05). For the square-wave transition, VO2 amplitude was significantly lower in CAD patients than CG group (10.1 ± 2.9 vs 13.1 ± 3.8 ml/kg/min, p<0.05). In contrast, VO2 baseline, time constant of the primary phase, gain and mean response time were not significant (p>0.05). The effective deoxy-[Hb+Mb] was not statistically different between groups (p>0.05). CONCLUSIONS: Long term ET in CAD participants had lower measured VO2peak and work load compared to age- and gender matched. However, both pulmonary and muscular oxygen kinetics were not slower in older adults with CAD compared to their training-matched counterparts. These findings support the importance on the referral of elderly patients to community-based cardiac rehabilitation ET program to maintain their submaximal pulmonary and muscle [HHb] kinetics to continue their ability to perform daily activities.