Exercise Dyspnea Research Articles

Equine pulmonary disease: a case control study of 300 referred cases. Part 2: Details of animals and of historical and clinical findings

Examination of historical and clinical details of 270 adult horses suffering from a variety of mainly chronic pulmonary diseases showed that the chronic obstructive pulmonary disease (COPD) group (median age 9 years) were the oldest, and that the COPD, chronic idiopathic hypoxaemia and exercise induced pulmonary haemorrhage (EIPH) groups had the longest duration of disease (median durations 7, 12 and 9 months, respectively) with a median disease duration of 2 months for the remaining horses. A history of antecedent respiratory infection was present in 24.3% of all horses. Six out of 12 horses that grazed with donkeys suffered lungworm infection. Silage was fed to 11.3% of all horses, nonstraw beddings were utilised by 28.7% of horses and 8.7% of horses were maintained permanently outdoors. Environmental control had been unsuccessfully attempted in 47% of COPD cases prior to referral. Histories of poor athletic performance or of excessive post exercise dyspnoea were found to be less definitive indicators of pulmonary disease. Coughing was the most sensitive clinical indicator of pulmonary disease, being present in 71.1% of horses with pulmonary disorders. Nasal discharge was present in 50.4% of these horses and coughing or nasal discharge was present in 86.7% of horses with respiratory disorders. Unilateral nasal discharge was inexplicably present in 3.3% of horses with pulmonary disease. Other clinical findings, including the presence of increased breathing effort, abnormal thoracic or tracheal auscultatory findings were less sensitive diagnostic parameters with pulmonary diseases, and were frequently absent unless severe pulmonary disease was present.

Dyspnée d'effort révélatrice d'un syndrome de Reynolds avec hypertension artérielle pulmonaire sévère

We report one case of a Reynolds syndrome (primary biliary cirrhosis and scleroderma) with severe pulmonary hypertension in a 65-year-old woman suffering from exercise dyspnea.

Dyspnea on Exercise: Pathophysiologic Mechanisms

To evaluate the frequency of the causes of exercise limitation in patients with chronic pulmonary disease and to assess the relationship between the resting pulmonary functional parameters and the degree of exercise dyspnea, we reviewed the data from 88 consecutive stable patients with chronic lung disease (62 COPD, 16 interstitial lung disease [ILD]). In each patient, the intensity of dyspnea was measured by a Borg scale (BS) during an incremental symptom-limited exercise test. COPD patients stopped exercise due to fatigue (46%), dyspnea (36%), cardiac limitation (12%), and peripheral circulatory limitation (6%). ILD patients stopped exercise due to dyspnea (62%), fatigue (25%), and cardiac limitation (12%). In all patients, dyspnea severity increased linearly with exercise intensity as measured as VO2, VE, and VE/MVV. The severity of dyspnea expressed as the slope of the relationship between BS and VE/MVV (DBS/D[VE/MVV]) showed in COPD a significant inverse correlation with VC, FEV1, MIP, and a positive correlation with PaCO2 and VE/MVV at rest. In ILD, DBS/D(VE/MVV) showed a significant inverse correlation with VC, FEV1, TLC, and PaO2 and a positive correlation with VE/MVV at rest. The predicting power of all equations was very low.

Effect of Alprazolam on Exercise and Dyspnea in Patients with Chronic Obstructive Pulmonary Disease

To evaluate the efficacy of a mild anxiolytic, alprazolam, in relieving dyspnea, we conducted a randomized, placebo-controlled double-blind study on patients with chronic obstructive lung disease. Twenty-four patients had alprazolam (0.5 mg bid) or placebo administered for one week, followed by placebo for one week, then either placebo or alprazolam for the third week. Assessment tests were performed at the outset, end of the first and second weeks, and finally end of the third week. The parameters measured were: pulmonary function, exercise testing on a bicycle ergometer, and the distance covered in a 12 minute walk. Subjective sensations of dyspnea at rest and during guarded exercise, as well as subjective feelings of calmness or anxiety were also recorded. There was no difference in mechanical lung function, but the PO2 tended to decrease and PCO2 to increase after alprazolam administration. The maximum exercise level attained and the distance covered in the 12 minute walk was unchanged. The subjective perception of dyspnea was the same before and after alprazolam, at rest and during exercise. We conclude that alprazolam is not effective in relieving exercise dyspnea in patients with obstructive lung disease.

Visual Analogue Scaling of Exercise Dyspnoea in Patients with Chronic Lung Disease

Visual Analogue Scaling of Exercise Dyspnoea in Patients with Chronic Lung Disease

Visual Analogue Scaling of Exercise Dyspnoea in Patients with Chronic Lung Disease

Conference Abstract| February 01 1984 Visual Analogue Scaling of Exercise Dyspnoea in Patients with Chronic Lung Disease J. W. Reed; J. W. Reed 1Departments of Physiological Sciences and Occupational Health & Hygiene, the University, Newcastle upon Tyne, NE2 4AA Search for other works by this author on: This Site PubMed Google Scholar C. M. Sprake; C. M. Sprake 1Departments of Physiological Sciences and Occupational Health & Hygiene, the University, Newcastle upon Tyne, NE2 4AA Search for other works by this author on: This Site PubMed Google Scholar J. E. Cotes J. E. Cotes 1Departments of Physiological Sciences and Occupational Health & Hygiene, the University, Newcastle upon Tyne, NE2 4AA Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1984) 66 (2): 56P–57P. https://doi.org/10.1042/cs066056Pb_pt2 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation J. W. Reed, C. M. Sprake, J. E. Cotes; Visual Analogue Scaling of Exercise Dyspnoea in Patients with Chronic Lung Disease. Clin Sci (Lond) 1 February 1984; 66 (2): 56P–57P. doi: https://doi.org/10.1042/cs066056Pb_pt2 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1984 The Biochemical Society and the Medical Research Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.

A new approach for the assessment of endurance work.

Thirteen young healthy motivated subjects were asked to work at fixed rates on bicycle ergometer till exhaustion. Different rates of work were given on different days at intervals of 2–3 days to avoid training effect or the effects of previous work. Resting O2 consumption, minute ventilation, heart rate and maximum voluntary ventilation were noted before the exercise commenced and the exercise ventilation and heart rate were noted during endurance effort at suitable intervals with a view to predicting endurance time in prolonged physical effort. Analysis of 30 sets of observations has revealed that endurance time is hyperbolically related to both exercise dyspnoea above its resting value and exercise heart rate above the resting value expressed as percentage of the individuals' maximum value. The multiple correlation coefficient between observed and estimated endurance times, expressed logarithmically in terms of these two indices, is 0.9652 which is highly significant (P 0.001). It has been conclusively established that a combined index of cardiorespiratory strains during maximal or near maximal efforts is superior to any single stress index as commonly employed, and hence a nomogram has been suggested from which the endurance time could be readily and reliably predicted from observed values of exercise dyspnoea and heart rate (as percentage of HRmax).

Hyperventilation and Effort Dyspnea in Porto-Pulmonary Bilharziasis

Thirty-one cases of portopulmonary bilharziasis with hyperventilation at rest and dyspnea on effort were subjected to a study of lung mechanics in conjunction with the clinical, respiratory and hemodynamic variations at rest and exercise. The cases were subdivided into three groups, according to the pulmonary artery pressure at rest and on exercise. There was a mild restrictive lung disease in all cases from focal interstitial fibrosis secondary to oval deposition. The lung compliance was manifestly affected, and more so on exercise, as the pulmonary artery pressures were raised. This was reflected in an increased oxygen cost of breathing. A physiologic disturbance for the resting hyperventilation and the exercise dyspnea could therefore be revealed among other causes discussed for this and similar symptomatology in other diseases.