Executive Function Tasks Research Articles

Anxiety disorders and executive functions: A three-level meta-analysis of reaction time and accuracy

Anxiety disorders, one of the most common classes of psychological disorders, have been shown to result in a decreased quality of life. Although some research suggests that anxiety disorders are linked to impairments in executive functioning, the inconsistency in the current literature yields an unclear conclusion on the relationship between the two. The current meta-analysis systematically investigated 55 records (N ​= ​4601; kReactionTime ​= ​44, kAccuracy ​= ​79) that compared various groups with anxiety disorders to healthy controls on executive function tasks. Overall, our meta-analysis showed that individuals with anxiety disorders exhibited significant deficits in performance efficiency (reaction times) on executive function tasks. However, we also found that individuals with anxiety disorders may outperform their healthy peers in performance effectiveness (task accuracy) in some conditions. Type of anxiety disorders, domain of executive functions, and mediation use were identified to moderate the overall relations between anxiety disorders and executive functioning. Nevertheless, the results were robust across important demographic and other clinical moderators (e.g., anxiety severity and comorbidity).

Genetic and environmental links between executive functioning and effortful control in middle childhood.

There is a need to understand the components of self-regulation, given its link to nearly every domain of functioning across the life span. This study examined the etiological underpinnings of covariance between measures of executive functioning (EF) and effortful control (EC) in middle childhood. The extent that genetic and environmental factors explain the association between EF and EC is unknown. Families were drawn from a longitudinal twin study (N = 894 twins; Mage = 8.87 years, SD = 1.10; 51.4% female; 46.8% non-Hispanic White, 28% Latino/a/x) and twins completed EF tasks during a home visit (Flanker Task, Continuous Performance Task, and Digit Span Backward) and primary caregivers (93.8% mothers) reported on their twins' EC (Attentional Focusing and Inhibitory Control). Univariate twin models showed additive genetic and nonshared environmental influences on the Flanker Task, Continuous Performance Task, Digit Span Backward, and parent-reported Inhibitory Control, and dominant genetic influences were implicated in parent-reported Attentional Focusing. Bivariate twin models revealed that additive genetic influences explained the small covariance between EF and EC. Executive attention could explain the genetic covariance between measures of EF and EC. This study suggests that EF and EC tap into the same underlying self-regulation construct, with weak correlations between constructs being attributed to measurement, rather than conceptual, differences. Elucidating the overlap between EF and EC can bring researchers closer to understanding how best to foster adaptive self-regulation. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Executive functions are important for academic achievement, but emotional intelligence too.

Finding predictors of academic achievement has caught the interest of many educational researchers in the last decades. Two of the variables that have received considerable attention are emotional intelligence (EI) and executive functions (EF). However, only a few studies have considered their influence in the primary school stage. The aim of this study is to identify which EI components and specific EF are most related to academic achievement and to explore if these relationships vary among subjects. The sample comprised of 180 students between 8-11 years old. We administered the BarOn EI Inventory, tasks of EF and tests of mathematic and linguistic competences. The results showed that EF are better predictors of school performance than EI. Inhibition and working memory were the EF most associated with achievement while adaptability emerged as the EI dimension most linked to it. This study suggests that EI and EF should be consciously developed in classrooms.

Functional near-infrared spectroscopy is a sensitive marker of neurophysiological deficits on executive function tasks in young adults with a history of child abuse

Previous research has shown the utility of imaging measures of neural activity in identifying deficits in cognitive functioning in individuals with a history of child abuse. The purpose of the present study was to measure differences that may exist between individuals who reported physical, emotional, or sexual abuse as children (n = 37) vs. those who did not (n = 47) using Functional Near Infrared Spectroscopy (fNIRS) during the completion of cognitive tasks of executive function. The results showed a significantly higher rate and number of errors of commission on the Conners CPT test in the child abuse group compared to the control group. The analyses also showed a statistically significant decrease in oxyhemoglobin (oxy-Hb) concentration in the left rostral prefrontal cortex in the child abuse group compared to the no-abuse group during the Wisconsin Card Sorting Test (WCST). A similar, albeit non-significant, trend toward decreased oxy-Hb concentration was observed in the child abuse group in the right dorsolateral prefrontal cortex (dlPFC) on the OSPAN and Connors CPT. The results suggest that the latter group may show subtle neurological deficits that persist into adulthood that may not manifest on traditional measures of cognitive function. These findings have implications for the development of remediation and treatment strategies in this population.

Bidirectional Associations Between Adiposity and Cognitive Function and Mediation by Brain Morphology in the ABCD Study

Most epidemiologic studies examine the brain as an outcome in relation to adiposity (ie, the brain-as-outcome perspective), but it is also a potential risk factor associated with adiposity accumulation over time (ie, the brain-as-risk factor perspective). The bidirectionality hypothesis has not been fully explored in adolescent samples previously. To assess bidirectional associations between adiposity and cognitive function in youth and test mediational pathways through brain morphology (specifically the lateral prefrontal cortex [LPFC]), lifestyle behaviors, and blood pressure. This cohort study uses data (wave 1-3; 2 years of follow-up) from the Adolescent Brain Cognitive Development (ABCD) Study, a long-term longitudinal investigation of brain development in the United States launched in 2015, which recruited 11 878 children aged 9 to 10 years at inception. Data analysis was performed from August 2021 to June 2022. Multivariate multivariable regression analyses were used to assess bidirectional associations of indicators of cognitive function (eg, executive function, processing speed, episodic memory, receptive vocabulary and reading skills) and adiposity (eg, body mass index z scores [zBMI] and waist circumference [WC]). Mediators considered for this investigation were lifestyle variables (eg, diet and physical activity), blood pressure, and the morphology of the LPFC and its subregions. A total of 11 103 individuals (mean [SD] age, 9.91 [0.6] years; 5307 females [48%]; 8293 White individuals [75%] and 2264 Hispanic individuals [21%]) were included in the current study. Multivariate multivariable regression analyses revealed that higher baseline zBMI and WC were associated with worse follow-up episodic memory (β, -0.04; 95% CI, -0.07 to -0.01) and better vocabulary (β, 0.03; 95% CI, 0.002 to 0.06) task performance, in covariate adjusted models. Similarly, superior baseline executive function (zBMI: β, -0.03; 95% CI, -0.06 to -0.01; WC: β, -0.04; 95% CI, -0.07 to -0.01) and episodic memory (zBMI: β, -0.04; 95% CI, -0.07 to -0.02; WC: β, -0.03; 95% CI, -0.06 to -0.002) task performance were associated with better follow-up adiposity status in covariate adjusted models. Cross-lagged panel models with latent variable modeling had a bidirectional association with executive function task performance (brain-as-outcome: β, -0.02; 95% CI, -0.05 to -0.001; brain-as-risk factor: β, -0.01; 95% CI, -0.02 to -0.003). The hypothesized associations were statistically mediated by LPFC volume and thickness, physical activity, and blood pressure. In this cohort study, executive function and episodic memory were bidirectionally associated with adiposity indices over time in this adolescent sample. These findings suggest that the brain can be both a risk factor and an outcome of adiposity; this complex bidirectional association should be taken into account in future research and clinical practice.

Evaluating the Distinction between Cool and Hot Executive Function during Childhood.

This article assesses the cool-hot executive function (EF) framework during childhood. First, conceptual analyses suggest that cool EF (cEF) is generally distinguished from hot EF (hEF). Second, both EFs can be loaded into different factors using confirmatory factor analyses. Third, the cognitive complexity of EF is similar across cEF tasks, and the cognitive complexity of cEF is similar to hEF tasks. Finally, neuroimaging analysis suggests that children activate the lateral prefrontal regions during all EF tasks. Taken together, we propose that the cool-hot framework is a useful, though not definitive way of characterizing differences in EF.

A microworld simulation of dynamic cognition as a test of executive function

ABSTRACT Introduction The lack of consensus regarding the nature or composition of executive functioning (EF) has led to a proliferation of executive tasks to assess the concept. Many do agree however that the theoretical concept of EF is a holistic one, leading us to consider whether it would be beneficial to assess EF in a more holistic manner. We explore how well a computerized simulation of dynamic cognition – that reproduces the context of real-world complex decision-making – can predict performance on nine classical neuropsychological tasks of EF. Methods A sample of 121 participants completed all tasks, and canonical correlations were used to assess the nine tasks as predictors of the three simulation performance metrics to evaluate the multivariate-shared relationship between the two variable sets: executive functions and dynamic cognition. Results Results show that a substantial amount of variance in two indices of dynamic cognition can be explained by a linear combination of three key types of neuropsychological tasks (planning, inhibition, working memory), with a larger contribution from the planning tasks. Conclusion Our findings suggest that tasks of dynamic cognition could augment traditional, separate tests of EF, offering benefits in terms of parsimony, ecological validity, sensitivity, and computerized delivery.

Effectiveness of a Single Prolonged Aerobic Exercise Session on Executive Function Task Performance in Physically Active Adults (21-70 Years of Age).

We sought to examine the effectiveness of an acute prolonged exercise session on post-exercise executive function in physically active adults and to assess if age or pre-exercise cognitive performance was predictive of the magnitude of change in executive task performance. Self-registered cyclists were recruited prior to participating in a 161-km mass-participation cycling event. Cyclists were excluded if they had not previously participated in a similar endurance event, were young (<18 y), or were cognitively impaired (Mini CogTM < 3 units). Immediately after completing the exercise session, the time taken to complete Trail Making Test Part A and Part B (TMT A + B) was assessed. A faster time to complete the TMT A + B was observed after exercise (+8.5%; p = 0.0003; n = 62; age range = 21-70 y). The magnitude of change in TMT A + B performance (pre vs. post) was influenced by pre-exercise TMT A + B performance (r2 = 0.23, p < 0.0001), not age (r2 =0.002; p = 0.75). Prolonged exercise had a small-to-moderate effect on post-exercise compared to pre-exercise executive function task performance (Cohen's d = 0.38-0.49). These results support the effectiveness of a single prolonged exercise bout to augment executive function in physically active adults, irrespective of age.

A critical review of hot executive functioning in youth attention-deficit/hyperactivity disorder: Methodological limitations, conceptual considerations, and future directions.

Hot executive functioning (EF) - EF under emotionally or motivationally salient conditions - is a putative etiology of attention-deficit/hyperactivity disorder (ADHD), disruptive behavior problems (DBPs), and their related impairments. Despite two decades of research, the present study is the first review of the construct in youth ADHD, with a particular focus on the role of task design, age, and DBPs, as well as relevant conceptual and methodological considerations. While certain hot EF tasks have been investigated extensively (e.g., choice impulsivity), substantial inconsistency in measurement of the broader construct remains, severely limiting conclusions. Future research should a) consider the extent to which various hot EF tasks relate to one another, a higher order factor, and other related constructs; b) further investigate task design, particularly the elicitation of emotion or motivation and its anticipated effect on EF; and c) incorporate multiple levels of analysis to validate similarities and differences among tasks with regard to the affective experiences and cognitive demands they elicit. With improved measurement and conceptual clarity, hot EF has potential to advance the literature on etiological pathways to ADHD, DBPs and associated impairments and, more broadly, may represent a useful tool for understanding the influence of emotion and motivation on cognition.

The effect of emotion regulation on executive function

ABSTRACT Emotion regulation and executive function are associated. However, if – and how – these two processes affect one another has not previously been explored; most studies have employed a correlational approach, leaving the direction of influence unknown. Using an experimental design, we aimed to explore the impact of emotion regulation on executive functioning. Adult participants (N = 31) completed a computerized executive functioning task under a neutral/baseline condition and three emotion regulation conditions: (1) positive mood-maintain, (2) negative mood-maintain, (3) negative mood-reduce. Relative to baseline, participants demonstrated better set-shifting performance across regulation conditions (likely reflecting practice effects). In contrast, inhibitory control performance in the emotion regulation conditions was slower, suggesting that inhibitory control may be more involved in the emotion regulation process than set-shifting. The present study provides preliminary evidence that individuals' executive function may be affected by concurrent emotion regulation demands; additional experiments are necessary to further probe the complexity of this association.

Executive Function Deficits and Borderline Personality Disorder Symptomatology in a Nonclinical Adult Sample: A Latent Variable Analysis.

While borderline personality disorder (BPD) symptomatology has been studied extensively in clinical populations, the mechanisms underlying its manifestation in nonclinical populations remain largely understudied. One aspect of BPD symptomatology in nonclinical populations that has not been well studied is cognitive mechanisms, especially in relation to executive functions. To explore the cognitive mechanisms underlying BPD symptomatology in nonclinical populations, we analysed a large-scale dataset of 233 young adults that were administered with nine executive function tasks and BPD symptomatology assessments. Our structural equation modelling did not find any significant relations between latent factors of executive functions and the severity of BPD symptomatology. Contrary to our hypothesis, our result suggests that deficits in executive functions were not a risk factor for BPD symptomatology in the nonclinical young adult sample.

Heart Rate Complexity and Autonomic Modulation Are Associated with Psychological Response Inhibition in Healthy Subjects

the ability to suppress/regulate impulsive reactions has been identified as common factor underlying the performance in all executive function tasks. We analyzed the HRV signals (power of high (HF) and low (LF) frequency, Sample Entropy (SampEn), and Complexity Index (CI)) during the execution of cognitive tests to assess flexibility, inhibition abilities, and rule learning. we enrolled thirty-six healthy subjects, recording five minutes of resting state and two tasks of increasing complexity based on 220 visual stimuli with 12 × 12 cm red and white squares on a black background. at baseline, CI was negatively correlated with age, and LF was negatively correlated with SampEn. In Task 1, the CI and LF/HF were negatively correlated with errors. In Task 2, the reaction time positively correlated with the CI and the LF/HF ratio errors. Using a binary logistic regression model, age, CI, and LF/HF ratio classified performance groups with a sensitivity and specificity of 73 and 71%, respectively. this study performed an important initial exploration in defining the complex relationship between CI, sympathovagal balance, and age in regulating impulsive reactions during cognitive tests. Our approach could be applied in assessing cognitive decline, providing additional information on the brain-heart interaction.

Predicting executive functioning from functional brain connectivity: network specificity and age effects.

Healthy aging is associated with altered executive functioning (EF). Earlier studies found age-related differences in EF performance to be partially accounted for by changes in resting-state functional connectivity (RSFC) within brain networks associated with EF. However, it remains unclear which role RSFC in EF-associated networks plays as a marker for individual differences in EF performance. Here, we investigated to what degree individual abilities across 3 different EF tasks can be predicted from RSFC within EF-related, perceptuo-motor, whole-brain, and random networks separately in young and old adults. Specifically, we were interested if (i) young and old adults differ in predictability depending on network or EF demand level (high vs. low), (ii) an EF-related network outperforms EF-unspecific networks when predicting EF abilities, and (iii) this pattern changes with demand level. Both our uni- and multivariate analysis frameworks analyzing interactions between age × demand level × networks revealed overall low prediction accuracies and a general lack of specificity regarding neurobiological networks for predicting EF abilities. This questions the idea of finding markers for individual EF performance in RSFC patterns and calls for future research replicating the current approach in different task states, brain modalities, different, larger samples, and with more comprehensive behavioral measures.

Piloting a Novel Daily Living Skills Assessment in Autistic Adolescents and Young Adults.

There are a few ecologically valid measurements of Daily Living Skills (DLS)-a critical component of adaptive functioning (AF)-for autistic adolescents and young adults. This is particularly important given that DLS predict outcomes as autistic adolescents transition to adulthood. We pilot-tested the assessment section of two modules of the Computerized Functional Skills Assessment and Training program (CFSAT) in 25 autistic (n = 4 female) and 25 non-autistic (n = 6 female) adolescents and young adults to evaluate preliminary feasibility in an autistic sample. Tasks involved using an ATM and ticket-buying machine. We also assessed AF and DLS with a well-validated self-report questionnaire. We examined group differences in performance and relationships between performance on CFSAT and an existing measure of AF and DLS. We also conducted regression analyses to investigate the associations between age, IQ, executive functioning (EF), and CFSAT task performance. All but one autistic participant were able to complete the CFSAT tasks. Autistic participants made more errors, but did not take longer to complete the task, than non-autistic participants. Performance correlated strongly with self-reported AF generally and DLS specifically. The regression analyses revealed that task performance was associated with EF in the autistic group, but not the non-autistic group. These results provide preliminary support for the use of a new performance-based ecologically valid assessment of DLS in an autistic population. Two CFSAT modules were well-tolerated and detected differences in DLS ability. Strong correlations with an existing measure of AF suggest evidence of construct validity. The EF was associated with CFSAT task performance in autistic individuals. Such a tool could help identify individuals who would benefit from a DLS intervention.

Does comorbid depression impact executive functioning (EF) in adults diagnosed with ADHD?: a comparison of EF across diagnoses in clinically-referred individuals

ABSTRACT Introduction Executive functioning (EF) is a salient factor in both ADHD as well as depressive disorders. However, sparse literature has examined whether depression severity impacts EF concurrently among adults with ADHD. The goal of this study was to examine differences in EF between adult patients diagnosed with ADHD and those diagnosed with a non-ADHD primary psychopathological condition, as a function of both ADHD presentation and depression severity in a diverse clinical sample. Method This crosssectional study included 404 adult patients clinically referred for neuropsychological evaluation to assist with differential diagnosis and/or treatment planning related to known or suspected ADHD. Various EF tasks and a measure of depression severity were administered. One-way MANOVA analyses were conducted to compare EF performance between individuals diagnosed with ADHD or a non-ADHD primary psychopathological condition, with additional analyses examining group differences based on ADHD presentation and depression severity. Regression analyses also examined the potential contribution of depression severity to each EF measure within each group. Results No significant EF performance differences were found when comparing individuals diagnosed with ADHD and those with a non-ADHD primary psychopathological condition, nor based on ADHD presentation. When comparing across groups using cut-offs for high or low depression, only one EF measure showed significant differences between groups. Further, depression severity generally did not predict reduced EF performances with the exception of verbal fluency and working memory performances in select groups. Conclusions This study demonstrated that individuals with ADHD generally perform comparably on EF measures regardless of the presence or absence of comorbid depression. These results suggest further examination of EF deficits when they emerge for adults with ADHD, especially beyond comorbid depression severity.

Rediscovering reliable components analysis: An application to executive function skills in early childhood.

Executive function (EF) assessments often involve the administration of multiple tasks. Although factor analytic methods are routinely used to summarize performance across multiple tasks, they may not be optimal for this purpose. We introduce reliable component analysis (RCA) as a strategy for summarizing EF task performance and demonstrate how it compares to traditional methods. Participants included 259 children (M = 4.5, SD = 0.6 years old; 55% female; 41% White, 35% Black, 14% Hispanic, 1% Asian, 1% American Indian, and 8% of more than one race) from the Kids Activity and Learning Study. Data collection occurred in center-based preschools and involved direct child assessments of EF, motor, and math skills. Principal components analysis (PCA), principal axis factor analysis (FA), and RCA methods were used to summarize children's performance across a battery of six EF tasks. Whereas PCA and FA indicated that a single composite or factor provided the best representation of EF task data, RCA indicated that three composites were justifiable. RCA composites were moderately to strongly correlated with PCA and FA scores (rs = .39-.79). Regression models indicated that all three approaches for combining EF task scores explained the same proportion of variance in motor and math skills outcomes, though the contributions of individual composite and factor scores varied. Results are discussed with respect to how RCA differs from more commonly used tools for data reduction. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Discounting and Executive functions as indicators of methamphetamine use in adolescents and adults

Abstract &#x0D; Meth-users have shown low performance in some executive functions tasks. This low performance can entail problems of control behavior, and increased impulsivity such as preference the small reward over the large delayed one. The current study was aimed to evaluate the performance in three executive tasks (shifting, updating and inhibition), and four discounting tasks (delay and probability) of gains and losses by meth-users and non-users. We worked with 40 male adults (20 meth-users and 20 non-users), and 32 male adolescents (20 meth-users and 12 non-users). We found with CART algorithm that inhibition, updating and probability discounting tasks were the good predictors to identify non users and meth-users. Our general conclusion is the executive functions: Inhibition and Updating are related with cognitive issues due to drug use in a developing brain, and the discounting tasks do not reflect a general impulsivity trait.

CELL SENESCENCE IS A FEATURE AND MODULATOR OF THE AGED INFLAMMATORY BRAIN CELL LANDSCAPE

Abstract New strategies to preserve cognitive function could broadly benefit the aging population. Cellular senescence is a hypothesized mediator of inflammation-related tissue dysfunction in aging. Using single-cell RNA-sequencing, we discovered an age-related brain myeloid population exhibiting overlapping senescent and disease-associated activation signatures, including upregulation of chemoattractant factors. We confirmed senescent brain myeloid cells promote peripheral immune cell chemotaxis in vitro. Through mass cytometry, we demonstrate age- and sex-dependent increases in activated resident and infiltrating brain immune cells are reduced through systemic targeting of p16-positive senescent cells, which is associated with improvements in executive function and spatial learning tasks. Our high-dimensional results reveal dynamic remodeling of the age-dependent brain immune cell landscape and implicate senescent cell targeting as a strategy to counter inflammatory changes and cognitive decline.

Executive functions neither associated with agentic extraversion nor sensitive to the dopamine D2 blocker sulpiride in a preregistered study

Initial studies suggest that extraversion and executive functions (EFs) are associated because of shared dopaminergic mechanisms. Aiming to conceptually replicate these findings we conducted a preregistered study to investigate (1) associations between extraversion and performance in three tasks (3-back, switching, AX-CPT) and (2) whether these associations are sensitive to administration of the dopamine D2 receptor blocker sulpiride in a placebo-controlled between-subjects design (N = 200). Against expectations, neither (agentic) extraversion, nor its interaction with substance condition explained performance in any of the EF tasks. As the current results are limited by an unexpectedly low reliability of the measures derived from the switching task and the AX-CPT, further preregistered studies using psychometrically superior measures are needed.

Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome.

Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and autism spectrum disorder. Executive function (EF), necessary for adaptive goal-oriented behavior and dependent on frontal lobe function, is impaired in individuals with FXS. Yet, little is known how alterations in frontal lobe neural activity is related to EF deficits in FXS. Sixty-one participants with FXS (54% males) and 71 age- and sex-matched typically-developing controls (TDC; 58% males) completed a five-minute resting state electroencephalography (EEG) protocol and a computerized battery of tests of EF, the Test of Attentional Performance for Children (KiTAP). Following source localization (minimum-norm estimate), we computed debiased weighted phase lag index (dWPLI), a phase connectivity value, for pairings between 18 nodes in frontal regions for gamma (30-55Hz) and alpha (10.5-12.5Hz) bands. Linear models were generated with fixed factors of group, sex, frequency, and connection. Relationships between frontal connectivity and EF variables also were examined. Individuals with FXS demonstrated increased gamma band and reduced alpha band connectivity across all frontal regions and across hemispheres compared to TDC. After controlling for nonverbal IQ, increased error rates on EF tasks were associated with increased gamma band and reduced alpha band connectivity. Frontal connectivity findings are limited to intrinsic brain activity during rest and may not generalize to frontal connectivity during EF tasks or everyday function. We report gamma hyper-connectivity and alpha hypo-connectivity within source-localized frontal brain regions in FXS compared to TDC during resting-state EEG. For the first time in FXS, we report significant associations between EF and altered frontal connectivity, with increased error rate relating to increased gamma band connectivity and reduced alpha band connectivity. These findings suggest increased phase connectivity within gamma band may impair EF performance, whereas greater alpha band connectivity may provide compensatory support for EF. Together, these findings provide important insight into neurophysiological mechanisms of EF deficits in FXS and provide novel targets for treatment development.