This comprehensive thematic review focuses on autobiographical memory (AM) in individuals with Autism spectrum disorder (ASD) with the overarching aim of informing and instructing stakeholders on this important memory structure that is often compromised in individuals with ASD. Accordingly, articles that best address the theme were selected from legitimate publishers with prime peer-reviewed journals. ASD is recognized as a neurodevelopmental disorder, often impacting on many aspects of language, cognitive, and social-emotional development. Considerable research has documented the problems children and adults with ASD frequently exhibit in language and its offshoots, the development of executive function, and theory of mind or the ability to reflect on the thoughts and feelings of self and others. These studies resulted in numerous assessments and intervention strategies designed to target the noted issues, among them problems with AM. Specialists in a variety of medical, psychological, and educational fields are exploring the nature and development of AM across the lifespan and the effects of AM weaknesses on cognitive and social-emotional factors such as self-regulation, social interactions, and self-identity. Researchers are reporting on the nature of AM deficits in persons with ASD and how AM deficits interact with or may explain other difficulties exhibited by these persons, but to date, little of this research has been incorporated into assessment and intervention strategies for persons with ASD. The aims of this article are to: 1. Describe the nature of AM, 2. Expound on assessments of AM, 3. Explain the effects of deficits in AMs on the personal narratives, self-regulation, and self-identity of persons with ASD, and 4. Explore intervention strategies to facilitate AM and the abilities of persons with ASD to tell coherent personal narratives.