Executive Function Research Articles

The impact and experience of directly teaching about executive functions (EF) to 2nd-grade students on their understanding and performance of EF skills

ABSTRACT Occupational Therapy Practitioners (OTPs) often support the development of executive function (EF) skills during direct service, while pushing into classrooms, and in consultation with teachers and other service providers. However, there is scarce literature about children’s perspectives on actively learning about EF skills. The present study seeks to understand two concepts regarding EF skills in children. First, how does direct education about EF skills with 2nd-grade students impact their perceived experience of using EF skills in a classroom setting? Second, does directly teaching EFs to second-grade students have an effect on their understanding and performance in the classroom? One 2nd-grade classroom at a school in Brooklyn, NY, received a 3-week intervention based on the EFs2theRescue program, focusing on three core EF skills: working memory, inhibition, and mental flexibility. Qualitative methods used a constructivist grounded theory approach and purposeful sampling to interview nine 2nd graders about their experiences. Participants described their positive experiences through using these strategies in their lives and reported that they are likely to utilize these skills in the future. School-based OTPs can explore using similar programs in their practice and support teachers in implementing direct teaching of EF in their classrooms.

Stress generation and subsequent repetitive negative thinking link poor executive functioning and depression

ABSTRACT Background and Objective Poor executive functioning (EF) has been consistently linked to depression, but questions remain regarding mechanisms driving this association. The current study tested whether poor EF is linked to depression symptoms six weeks later via dependent stressors (model 1) and stressors perceived to be uncontrollable (model 2) at week two (W2) and repetitive negative thinking (RNT) at W4 during early COVID-19 in college students. Design This was a longitudinal study with four timepoints spanning six weeks (April–June 2020). Methods Participants (N = 154) completed online questionnaires measuring EF, dependent stress frequency, stress controllability appraisals, brooding rumination, worry, and depression. Results Supporting model 1, poorer baseline EF predicted higher dependent stress frequency at W2; W2 dependent stress frequency, in turn, predicted increases in W4 RNT, which predicted increases in W6 depression. Model 2 was not supported: Baseline EF did not predict W2 perceived stress uncontrollability, which did not predict W4 RNT; however, W4 RNT predicted increases in W6 depression. Limitations The sample was relatively small and EF was measured using only self-reports. Conclusions Findings supported a model in which poor EF conferred risk for depression via dependent stress and subsequent RNT, highlighting these processes as risk mechanisms for depression.

Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis.

Psilocybin shows promise for treating neuropsychiatric disorders. However, insight into its acute effects on cognition is lacking. Given the significant role of executive functions in daily life and treatment efficacy, it is crucial to evaluate how psilocybin influences these cognitive domains. This meta-analysis aims to quantify the acute effects of psilocybin on executive functions and attention, while examining how dosage, timing of administration, cognitive domain, and task characteristics moderate these effects. A systematic review and multilevel meta-analysis were conducted on empirical studies assessing psilocybin's acute effects on working memory, conflict monitoring, response inhibition, cognitive flexibility, and attention. Effect sizes for reaction time (RT) and accuracy (ACC) were calculated, exploring the effects of timing (on-peak defined as 90-180min post-administration), dosage, cognitive function categories, and task sensitivity to executive functions as potential moderators. Thirteen studies (42 effect sizes) were included. In the acute phase, psilocybin increased RTs(Hedges' g = 1.13, 95% CI [0.57, 1.7])and did not affect ACC (Hedges' g = -0.45, 95% CI [-0.93, 0.034]). Effects on RT were dose dependent. Significant between-study heterogeneity was found for both RT and ACC. Task sensitivity to executive functions moderated RT effects. Publication bias was evident, but the overall effect remained significant after adjustment for this. Our meta-analysis shows that psilocybin impairs executive functions and results in a slowing down of RT. We discuss potential neurochemical mechanisms underlying the observed effects as well as implications for the safe use of psilocybin in clinical and experimental contexts.

Could physical activity promote indicators of physical and psychological health among children and adolescents? An umbrella review of meta-analyses of randomized controlled trials.

We performed an umbrella review to synthesize evidence on the effects of physical activity (PA) interventions on indicators of physical and psychological health among children and adolescents, including body mass index (BMI), blood pressure (BP), depressive symptoms, and cognitive function. PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched from inception through 31 July 2023. We included meta-analyses of randomized controlled trials exploring the effects of PA interventions on BMI, BP, depressive symptoms, or cognitive function in healthy or general children and adolescents. Standard Mean Difference (SMD) was calculated for continuous outcome indicators, while Relative Risk (RR) was calculated for categorical outcome indicators. A total of 21 meta-analyses were included. The evidence for the effects of PA interventions on reducing BMI [n = 68,368, SMD = - 0.04, 95% confidence interval (CI) = - 0.07 to - 0.01, P = 0.012, I2 = 46.6%], relieving diastolic BP (n = 8204, SMD = - 1.16, 95% CI =- 2.12 to - 0.20, P = 0.018, I2 = 83.1%), preventing depressive symptoms (n = 5146, SMD = - 0.21, 95% CI =- 0.31 to - 0.12, P < 0.001, I2 = 29.0%), and promoting cognitive function (n = 19,955, SMD = 0.40, 95% CI =0.27-0.54, P < 0.001, I2 = 88.0%) was all weak but significant (class IV evidence). Subgroup analyses demonstrated that school-based and after-school PA interventions, curricular PA interventions, and PA interventions emphasizing enjoyment were more effective in reducing BMI, while curricular PA and sports programs achieved greater executive function. PA interventions could weakly reduce BMI, relieve BP, prevent depressive symptoms, and promote cognitive function in general children and adolescents. Targeted interventions on PA should be a priority to promote physical and psychological health for children and adolescents, especially the curricular PA emphasizing enjoyment in the school settings.

Dude sponsored: how executive function and disclosures moderate the persuasive effects of sponsored online videos on young adults

PurposeThis study aims to examine how individual differences and contextual factors affect audience responses to sponsored video content. Specifically, this study tests whether executive function (EF, both hot and cool) skills in young adults influence persuasion knowledge and advertising responses. The study further tests the moderating role of disclosure presence and country of participants (US vs The Netherlands).Design/methodology/approachAn online experiment (N = 368) with a 2 (disclosure: present versus absent) × 2 (country: US versus The Netherlands) between subjects design featuring young adults (M age = 21.06; SDage = 3.06) is conducted.FindingsParticipants with more advanced cool EF showed a better understanding of the persuasive intent of the video, and hot EF was associated with higher brand recall. In addition, disclosures only enhance the understanding of persuasive intent of the video for people with less advanced levels of hot EF. Lastly, Dutch participants were more responsive toward the disclosure.Originality/valueThis study provides key insights regarding how young adults process sponsored content and the role that cognition plays in shaping responses.

The structure of executive functions in athletes: A latent variable approach.

The role of executive function (EF) in expert sport performance has become a popular topic in sport and exercise psychology research. Research in this area often adopts the unity/diversity framework of EF (i.e., inhibition, shifting, and updating). However, recent investigations into the suitability of this unity/diversity model, and other competing models (e.g., the nested model of EF), has questioned whether this model is suitable for across all populations (e.g., athletes). The aim of the present study was to use confirmatory factor analysis to outline the most suitable EF model in a sample of athletes. In total, 131 participants with varying levels of athletic expertise completed two inhibition, shifting, and updating tasks. All analyses were performed in RStudio. The results revealed the nested model of EF provided the best fit to the data indicating its suitability for athletes. Acceptable fit was also found for the unity/diversity mode of EF. Overall, the results suggest that, despite recent criticism of the nested model and unity/diversity framework of EF, such structures appear to be suitable for use with athletic populations.

Physical activity, cathepsin B, and cognitive health.

Regular physical activity (PA) is beneficial for cognitive health, and cathepsin B (CTSB) - a protease released by skeletal muscle during PA - acts as a potential molecular mediator of this association. PA-induced metabolic and mechanical stress appears to increase plasma/serum CTSB levels. CTSB facilitates neurogenesis and synaptic plasticity in brain regions (e.g., hippocampus and prefrontal cortex) that support performance in specific cognitive domains including memory, learning, and executive function. However, the evidence regarding the role of PA-induced changes in CTSB as a mediator of PA-induced cognitive health in humans is mixed. To guide future research, this article identifies key factors that may explain the observed heterogeneity in the findings from human studies and proposes a PA-CTSB-cognition model.

Examining the factor structure of the home learning environment.

The home learning environment (HLE) is an important context for fostering early development. Literature supports four subdomains of the HLE: home literacy, numeracy, executive function, and science environments. The current study examined the factor structure of the HLE with all four domain-specific established scales. Participants (N=913) were caregivers (primarily White; 78.1%) of children aged 2 to 6 years (M=4.28 years, SD=1.25). Data were collected from an online platform. Results suggested that the most appropriate structure was a seven-factor model (code-based and oral language literacy, informal and formal numeracy, core and practice science, and executive function). Caregivers reported engaging in literacy practices the most and engaging in science and numeracy activities the least. This study demonstrates that the HLE is a multidimensional structure.

Effect of leisure activities on cognitive and memory function in older adults: A systematic review and meta-analysis of randomized controlled trials.

Cognitive decline is an increasingly serious global health challenge. In recent years, an increasing number of non-traditional cognitive rehabilitation training (N-TCRT) interventions have been applied to improve cognitive function, however, Tthe existing evidence is restricted. The meta-analysis of this randomized controlled trial evaluated the efficacy of leisure activity interventions compared to TCRT control on cognitive function in older adults. A literature search was conducted on PubMed, Embase, Cochrane Central Register of Controlled Trials, and related databases through June 31, 2024. The risk of bias was assessed using the PEDro scale. A total of 23 included RCTs (n=1,293) utilized mahjong, poker, VR, and other games. Results show that leisure activities interventions improve global cognition function (MOCA, P<0.00001; MMSE, P<0.0001), memory function (DSB, P=0.002; DSF, P=0.03), executive function (TMT-A, P=0.0009; TMT-B, P=0.005) and quality of life (ADL, P<0.000001; WHOQOL-OLD, P<0.00001). In summary, leisure activities can improve some cognitive domains in older adults. (PROSPERO registration: CRD42024563951).

Preliminary validation of CCRacer serious game for assessing executive function after acquired brain injury.

Acquired brain injuries can profoundly impact executive functioning, yet traditional neuropsychological assessments often have limitations, such as being time-intensive, lacking ecological validity, or failing to engage patients effectively. To address these challenges, CCRacer, a serious game, was developed as a novel tool for assessing executive functions in clinical populations. This study evaluated the convergent and discriminant validity of CCRacer by applying it alongside established neuropsychological tests to a sample of 78 participants with acquired brain injury. Results revealed varying levels of convergent validity across tasks, with stronger correlations for measures of working memory (0.28-0.51) and planning (-0.46 to 0.34) and weaker correlations for inhibitory control (0.22). These findings suggest that CCRacer has the potential as a complementary tool in the neuropsychological assessment of an acquired brain injury, combining engaging and ecologically valid testing with the possibility of future use in cognitive training.

The Goal Processing Scale: cognitive correlates of an ecologically valid measure of executive functioning in mild traumatic brain injury

The Goal Processing Scale: cognitive correlates of an ecologically valid measure of executive functioning in mild traumatic brain injury

Maternal education and prenatal smoking associations with adolescent executive function are substantially confounded by genetics.

Twin studies have suggested extremely high estimates of heritability for adolescent executive function, with no substantial contributions from shared environment. However, developmental psychology research has found significant correlations between executive function outcomes and elements of the environment that would be shared in twins. It is unclear whether these seemingly contradictory findings are best explained by genetic confounding in developmental studies or limitations in twin studies, which can potentially underestimate shared environment. In this study, we use genetic and phenotypic data from 5,939 participants, 4,827 participant mothers, and 2,903 participant fathers in the Millennium cohort to examine the role of genetics in explaining common environmental associations with executive function, assessed by the spatial working memory (SWM) task and Cambridge Gambling task. Bivariate genome-wide complex trait analysis (GCTA) revealed that single-nucleotide polymorphism effects were the sole significant predictor of the association between SWM and both maternal education and prenatal smoking. maternal GCTA and trioGCTA also found no significant evidence of indirect genetic effects on SWM, indicating that genetic nurture is unlikely to explain the bivariate GCTA results. The Cambridge Gambling task showed no significant single-nucleotide polymorphism heritability, suggesting that genetic influences on hot executive function may differ significantly from those on cool executive function. This study supports the twin study claim that the working memory component of executive function is primarily a genetic trait with minimal influence from shared environment, emphasizing the importance of using genetically sensitive designs to ensure that genetic confounding does not falsely inflate estimates of environmental influences on traits. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Factor structure and measurement invariance of the Childhood Executive Functioning Inventory (CHEXI) across parents and teachers in Portuguese children

ABSTRACT The Childhood Executive Functioning Inventory (CHEXI) is a rating scale that evaluates everyday behaviors associated with executive functions in children. This study aimed to investigate the factor structure and the measurement invariance across parents and teachers of the CHEXI in a sample of 279 Portuguese typically developing children (6 to 12 years old, n = 160 girls and n = 119 boys). Most studies only analyzed the original two-factor model, and the few that investigated the four-factor model found a nearly identical fit between both factor structures. Confirmatory factor analysis was used to test five competing factor models and the four-factor models (slightly better than the two-factor model) demonstrated the most adequate fit to the data for both parents and teachers. The CHEXI showed adequate reliability and convergent validity with the BRIEF2. The measurement invariance of the four-factor model across parents and teachers was fully supported (configural, metric, and scalar invariance). Overall, the CHEXI showed adequate psychometric properties, suggesting that is a useful instrument to assess executive functioning based on reports of behaviors observed by parents and teachers in Portuguese typically developing children.

Fourteen weeks of β-alanine supplementation and HIIT did not improve serum BDNF concentrations and Stroop test performance.

This study aimed to investigate whether 14 weeks of β-alanine supplementation and high-intensity intermittent training improves brain-derived neurotrophic factor concentrations and cognitive aspects related to executive functions assessed by the Stroop test. Thirteen healthy and active men underwent a 4-week supplementation period (β-alanine: 6.4 g/d or a placebo) followed by 10-week supplementation combined with high-intensity intermittent training, totaling 14 weeks of intervention. Participants underwent a graded exercise test, while the blood samples for brain-derived neurotrophic factor analysis and the Stroop test (cognitive task) were assessed before and after a high-intensity intermittent exercise (10 runs of 1:1 min effort and a pause ratio at 130% of respiratory compensation point). These measurements were performed three times across the study being at baseline, after 4 weeks of supplementation (POST4weeks) and at the end of the 14 weeks of study (POST14weeks). Compared to baseline values, there were no improvements in brain-derived neurotrophic factor concentrations or Stroop test performance with either β-alanine or high-intensity intermittent training. Lactate peak concentrations in a high-intensity intermittent exercise session also did not differ between groups. However, high-intensity intermittent training did improve some cardiorespiratory parameters (i.e., intensity associated with V̇O2max p=0.01 and respiratory compensation point, p=0.01). In conclusion, β-alanine supplementation alone or associated with high-intensity intermittent training did not improve the brain-derived neurotrophic factor concentrations and Stroop test performance in healthy men.

Type 2 diabetes mellitus: A cross-sectional analysis of glycemic controls and brain health outcomes

In this cross-sectional analysis, we explored how fluctuations in glycemic levels impact executive functions and psychosocial outcomes in patients with type 2 diabetes mellitus (T2DM). The goal was to understand the relationship between glycemic control and both neuropsychological and psychosocial health. We stratified participants into well-controlled and poorly controlled groups based on glycated hemoglobin (HbA1c) levels and variability, including a healthy control group for comparison. The study consisted of neuropsychological tests and psychosocial assessments. Results indicated that the poorly controlled T2DM group experienced significant executive dysfunction and scored lower on the Tower of London, Wisconsin Card Sorting, and Digit Span Tests, reflecting a broader impact on quality of life and resilience. These findings support the importance of maintaining stable glycemic levels for better executive and psychosocial outcomes and highlight the need for regular neuropsychological and psychosocial assessments in diabetes care.

Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain in Mice.

Deep brain stimulation (DBS) using electrical stimulation of neuronal tissue in the basal forebrain to enhance release of the neurotransmitter acetylcholine is under consideration to improve executive function in patients with dementia. While some small studies indicate a positive response in the clinical setting, the relationship between DBS and acetylcholine pharmacokinetics is incompletely understood. We examined the cortical acetylcholine response to different stimulation parameters of the basal forebrain. 2-photon in vivo imaging was combined with deep brain stimulation in C57BL/6J mice. Stimulating electrodes were implanted in the subpallidal basal forebrain, and the ipsilateral somatosensory cortex was imaged. Acetylcholine activity was determined using the GRABACh-3.0 acetylcholine receptor sensor, and blood vessels were visualized with Texas red. Experiments manipulating stimulation frequency demonstrated that integrated acetylcholine induced fluorescence was insensitive to frequency with the same number of pulses, and that maximum peak levels were achieved with frequencies from 60 to 130 Hz. Altering pulse train length indicated that longer stimulation resulted in higher peaks and more activation with sublinear summation. The acetylcholinesterase inhibitor, donepezil, increased the peak response to 10s of stimulation at 60Hz, and the integrated response increased 57% with the 2 mg/kg dose, and 126% with the 4 mg/kg dose. Acetylcholine levels returned to baseline with a time constant of 14 to 18 seconds. Donepezil increases total acetylcholine receptor activation associated with DBS but did not change temporal kinetics. The long time constants observed in the cerebral cortex add to the evidence supporting volume and synaptic neurotransmission.

Clinical Interplay Between Autism Spectrum Disorder and Bipolar Disorder: A Narrative Review.

Autism Spectrum Disorder (ASD) and Bipolar Disorder (BD) present significant challenges in diagnosis due to their complex nature. This review aims to examine the interface and overlapping features of these conditions. We conducted a narrative review to examine clinical overlap, common psychiatric comorbidities, and shared neurobiological bases between ASD and BD. There is a notable convergence of symptoms in ASD and BD, including mood instability and emotional dysregulation; irritability, impulsivity, and aggressive behavior; deficits in social skills and social cognition; impairments in executive functions; sleep disturbances; problematic sexual behaviors; and sensory sensitivities. Common psychiatric comorbidities and shared neurobiological basis further underscore this potential interplay. Despite distinct clinical trajectories and diagnostic criteria, our findings indicate a significant overlap in symptoms and clinical presentations between ASD and BD. This complexity makes it challenging to identify the co-occurrence of ASD and BD, which can lead to difficulties in accurately diagnosing and managing both conditions simultaneously.

The role of Iowa gambling task performance in response to citalopram treatment for cocaine use disorder

ABSTRACT Background: Cocaine use disorder (CUD) is associated with executive functioning impairments linked to serotonergic function. Previous studies reported efficacy with the selective serotonin reuptake inhibitor citalopram in reducing cocaine use. Objectives: The current study explored moderation and mediation of citalopram effects on cocaine use by performance across executive function domains. Methods: We conducted a secondary analysis of a double-blind, placebo-controlled, randomized Bayesian adaptive trial investigating citalopram efficacy in CUD treatment-seeking adults. At baseline and mid-treatment, participants completed assessments of decision-making (Iowa Gambling Task; IGT), attention, response inhibition, and cognitive flexibility. Outcomes were longest duration of abstinence (LDA; count of consecutive cocaine-negative urine tests) and Treatment Effectiveness Score (TES; count of cocaine-negative urine tests from study midpoint to endpoint). Bayesian models estimated independent moderation and mediation effects of cognitive ability on the association between treatment (citalopram 40 mg vs. placebo) and LDA/TES. Results: Of the four assessments, only the IGT demonstrated concurrent moderation and mediation in the sample (N = 80; 82% males). Treatment effects on LDA (IRR = 1.02) and TES (IRR = 1.03) were strongest in participants with higher baseline IGT scores, which indicate less risky decision-making (posterior probabilities >93%). Models supported a positive indirect effect of treatment on TES (IRR = 1.12, posterior probability = 81.6%), with 52.3% of the total effect mediated by changes in IGT scores from baseline to mid-treatment. Conclusion: We found evidence for IGT as a moderator and mediator of citalopram’s effects on cocaine use. Decision-making ability may play a role in predicting who responds to citalopram and how.

Effects of oxytocin administration on non-social executive functions in humans: a preregistered systematic review and meta-analysis.

Oxytocin has received considerable research attention for its role in affiliative behaviors, particularly regarding its pro-social effects. More recent evidence has pointed to a broader role of oxytocin signaling, which includes non-social cognitive processes. However, meta-analytic data on oxytocin's effects on non-social cognition is currently limited. We registered plans for a systematic review and meta-analysis on the effects of oxytocin administration on non-social executive functions prior to data collection via a time-stamped protocol. We performed searches in PubMed, Europe PubMed Central, and the Bielefeld Academic Search Engine. We conducted a meta-analysis of 20 effect estimates from 13 eligible studies. Subgroup meta-analyses and a test for publication bias were also performed. We found no overall significant effect of oxytocin administration on non-social executive functions (p = 0.30; Hedges' g = 0.07). However, effect sizes across sub-categories of executive function varied, where the effect of oxytocin administration was the largest for cognitive flexibility (p = 0.02; Hedges' g = 0.2). Publication bias was assessed using Robust Bayesian Meta-Analysis, which yielded moderate support for the absence of publication bias (BFPB = 0.32). Our analysis suggests that oxytocin's effects may extend beyond social cognitive processing as data synthesis provided evidence supporting a role in non-social cognitive flexibility. The data and analysis output from this meta-analysis can be viewed in a point-and-click web application.

Utility of Parent and Teacher Behavior Ratings for Self-Regulatory Outcomes of Preschool Children: A Multi-Study Examination.

Despite frequent reliance on teacher and parent ratings of children's behavior for multi-informant assessment, agreement between teachers' and parents' ratings is low. This study examined the predictive utility of teacher and parent ratings for children's self-regulatory outcomes (i.e., executive function, continuous performance task) in four studies. Study 1 included 163 children ranging from 31 to 84 months of age (M = 55.58 months, SD = 8.43). Study 2 included 1,088 children ranging from 48 to 63 months of age (M = 55.15, SD = 3.65). Study 3 included 246 bilingual Spanish-speaking children ranging from 40 to 72 months of age (M = 56.66, SD = 6.06). Study 4 included 280 children ranging from 38 to 75 months of age (M = 55.92, SD = 4.16). Across studies, parents and teachers rated children's externalizing behaviors on the Conners' Rating Scale, the Strength and Weaknesses of ADHD-Symptoms and Normal Behavior Scale, or both; children completed a variety of performance-based self-regulation tasks. The strength of associations of parent and teacher ratings with self-regulatory outcomes was compared, and regression analyses determined the unique and overlapping variance accounted for by different raters. Teachers' ratings had larger associations with self-regulation than did parents' ratings across outcomes and studies-except for two instances in Study 4 where the associations for teachers' and parents' ratings were equal. These findings indicate that teachers supply more useful information than parents, possibly because teachers have better-informed expectations of children's behavior, and they raise questions about the utility of multi-informant assessment, at least with preschool children.