Daniels and Everson1 have recently reported that the intake of acetylsalicylic acid increases the urinary excretion of vitamin C in children. Such an action of this drug would be important but to us it seemed unlikely that acetylsalicylic acid had this effect. During a 4-months study of the vitamin C excretion of several subjects kept on a fairly constant intake of the vitamin the drug was taken on several occasions by various subjects without apparent effect on vitamin C excretion.2 During this time the output of vitamin C remained quite constant, except for intentionally produced variations. Although slight unexplained variations in excretion occasionally occurred, in no instance could they be related to administration of the drug, despite close observation to relate unexplained variations to such factors.The authors referred to above, state that acetylsalicylic acid “as such or combined with urine” does not react with the 2.6 dichlorophenolindophenol indicator commonly used. It; is not clear, however, ...