The effects of dietary EDTA (300 ppm) and cadmium (350 ppm) on absorption, excretion and tissue distribution of 65Zn were determined following a single oral dosing in zinc-deficient and normal calves and goats. The feeding of EDTA had no significant effect upon fecal excretion or tissue distribution of 65Zn. However, there was a marked increase in urinary 65Zn excretion among the EDTA-fed animals which persisted throughout the experimental period. Dietary cadmium decreased absorption and tissue concentration of 65Zn. When 65Zn was calculated as percentage of absorbed dose most tissues of cadmium-fed animals contained amounts comparable to those of other animals. However, livers of cadmium-fed calves, but not goats, had more 65Zn as a percentage of absorbed dose than livers of other animals. Cadmium had little effect on urinary excretion of 65Zn. In general the effects of dietary EDTA and of cadmium in zinc-deficient animals were comparable to those in normal animals.