Introduction: Human Milk is considered the ideal nutrition for all babies especially in preterm and in low birth-weight babies. When mother’s milk is not available, the WHO recommends Pasteurised Donor Human Milk (PDHM) as the next best infant feeding alternative. Methodology: This observational study was conducted in a tertiary level NICU in India to assess the impact of Human Milk Bank (HMB) on mortality and morbidities in VLBW and ELBW neonates. The primary outcome was to compare the incidence of definite and advanced NEC and secondary outcomes were to assess death, exclusive breastfeeding at discharge, feed interruption and growth in both the groups. Pre-Human Milk bank and Post-human Milk Bank data were collected for a period of 24 months each. Results: The incidence of Definite and Advanced NEC was significantly lower in Post-HMB group (2;1.76%) than in Pre-HMB (10; 9.4%) (p=0.00). 43.4% of babies in Pre-HMB group and 19.5% babies in post-HMB group had NEC (Any stage); p=0.00. Neonatal deaths were higher in the Pre-HMB group 32 (30.2%) than in post-HMB group 22 (19.5%); (p=0.066). The exclusive breastfeeding rate was significantly higher in the post-HMB group 72.6% as compared to 30.2% in the pre-HMB group (p=0.00). Feed interruptions were significantly lower in the post-HMB group 29 (25.7%) as compared to Pre-HMB group 56 (52.8%) (p=0.00). Time to reach full feeds was significantly lower in the post-HMB group Median (IQR) 13 (7.25 – 25.75) days as compared to 10 (5 – 17) days (p=0.007). Time to regain birth weight was significantly lower in the post-HMB group (14.72 + 5.61) as compared to pre-HMB group (11.00 + 4.19) (p=0.00) Conclusion: Establishment of Human Milk bank can be a worthwhile quality improvement project that NICUs can launch as part of comprehensive plans to enhance preterm care.
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