Epilepsy is a critical neurological condition characterized by the disturbance of the excitatory neuron network, resulting in recurrent seizures. It is a serious health problem requiring intensive attention. The present study was designed to use bibliometric analysis to assess scientific research output on pharmacogenetics in epilepsy and drug-resistant epilepsy in Morocco during 1969–2024. The main objective of this study was to analyze scientific production and research development and to introduce available solutions to manage the elevating burden of epilepsy. The strategy approach comprised a suitable search scheme to collect publications related to epilepsy using the Scopus database. All the documents retrieved were analyzed to determine several parameters, including the number of publications annually, type of documents, institution and author productivity, and relevant sources. Studies on pharmacogenetics and drug-resistant epilepsy in Morocco are limited. The findings revealed that the number of articles has increased during the last decade. Publications remain scarce, especially on pharmacogenetics and drug-resistant epilepsy, and the most widely available publications include articles on epilepsy, seizures, mental illness, and anticonvulsant agents. Based on the search strategy, a bibliometric analysis identified potential subjects for further study. Consequently, research on epilepsy is essential to fully understand the condition, but it remains insufficient, and further studies are required, particularly on the pharmacogenetics of epilepsy.