Abstract This Letter investigates the electron heat flux instability using the radial models of the magnetic field and plasma parameters in the inner heliosphere. Our results show that both the electron acoustic wave and the oblique whistler wave are unstable in the regime with large relative drift speed (ΔV e ) between electron beam and core populations. Landau-resonant interactions of electron acoustic waves increase the electron parallel temperature that would lead to suppressing the electron acoustic instability and amplifying the growth of oblique whistler waves. Therefore, we propose that the electron heat flux can effectively drive oblique whistler waves in an anisotropic electron velocity distribution function. This study also finds that lower-hybrid waves and oblique Alfvén waves can be triggered in the solar atmosphere, and that the former instability is much stronger than the latter. Moreover, we clarify that the excitation of lower-hybrid waves mainly results from the transit-time interaction of beaming electrons with resonant velocities v ∥ ∼ ω/k ∥, where ω and k ∥ are the wave frequency and parallel wavenumber, respectively. In addition, this study shows that the instability of quasi-parallel whistler waves can dominate the regime with medium ΔV e at the heliocentric distance nearly larger than 10 times of the solar radius.