Phyllodes tumors of the breast are rare fibro-epithelial tumors, representing 1% of primary breast tumors. Their diagnosis is histological. The aim of our work is to determine the epidemiological, clinical, histological, therapeutic, and prognostic characteristics of these tumors. This is a retrospective study conducted in the gynecology department at the MOULAY ISMAIL Meknes military hospital, over a period of 10 years, involving 20 patients who had histologically proven breast phyllodes tumors. The average age of onset of phyllodes tumors was 32 years, 80% of patients were multiparous. The mode of revelation was clinical, dominated by the increase in breast volume in 90% of patients, the right breast was the most affected by the tumor, and the QSE was the site of 60% of these tumors. The average tumor size was 6 cm. Confirmation of the diagnosis was histological after micro biopsy or lumpectomy, and conservative treatment was decided in 90% of cases while 10% benefited from radical treatment. Radiation therapy was reported in 2 women. The follow-up was marked by a favorable evolution in 16 cases, 2 cases of death were noted, while two women presented a local recurrence and were revised surgically. Phyllodes tumors of the breast mainly affect young women, and their treatment is based on surgery with a healthy excision margin greater than 1 cm. The evolution is marked by local recurrences, and most often lung or bone metastases. The prognosis is based on the histological characteristics of the tumor and on the quality of the surgical excision.