Excision Of Squamous Cell Carcinoma Research Articles

A bilateral orbital exenteration

A 44-year-old man developed within a few years a recurring squamous cell ca reinoma in both orbits. Despite surgery and radiotherapy it was necessary in the end to exenterate the left orbit and later on the right orbit as well. The patient is in a perfect state of health for more than five years now. It appears that excision of squamous cell carcinoma of the eyelid not only must have a wide margin but in particular, must be very deep.

Excision of selected intraoral cancers by use of sagittal inner table mandibulectomy.

The application of oral surgery osteotomy techniques, which are used in orthognathic surgery, to excision of squamous cell carcinomas in various oral cavity locations is described and illustrated in eight cases. These methods allow the full height of the inner table of the mandible to be removed as a margin for tumors which abut the lingual mucoperiosteum without radiologic evidence of bone erosion, while jaw continuity via the intact outer cortex is maintained. These techniques can also be used for marginal mandibulectomy and horizontal maxillectomy. Discussion includes criteria for selection of cases appropriate for such conservation surgery with respect to oncologic considerations, as well as complications encountered and their prevention.

Use of Submandibular Flap to Close Pharyngostomes and Other Defects of Lower Anterior Neck Region

We describe the use of a suprahyoid flap for reconstruction in the lower anterior neck. It has been most useful for immediately closing pharyngostomes and for resurfacing defects from the excision of squamous cell carcinoma of the larynx or other neoplasms involving the skin. This flap provides a good deal of viable tissue, it can easily be rotated without a delay procedure, and the donor area is closed by direct suture. We present our experience with 22 cases.

Oral contraceptives containing oestrogens.

<h3>Objectives:</h3> This paper describes the results of a retrospective study of surgical approaches and recurrence rates relating to patients with squamous cell carcinoma (SCC) of the vulva. The aim of this study was to analyze the histological margins in relation to recurrence rate and survival. <h3>Methods:</h3> A retrospective chart review of 93 cases of vulvar cancer. The data collected included clinicopathological and surgical characteristics and the following potential risk factors: pathological margin distance, less than 8 mm; stromal invasion depth, more than 2.5 mm; tumor size; and presence of benign or premalignant epithelial disorders. <h3>Results:</h3> Ninety-three patients (median age, 74 years) underwent modified radical vulvectomy, hemi-vulvectomy, or local wide excision for SCC of the vulva from 2000 to 2005. The tumor was radically removed in 80 patients (86%), although the histopathological margin was less than 8 mm in 50 patients (54%). Eighteen patients (23%) developed a local recurrence. The recurrence rate did not differ between patients in whom the margin distance was 8 mm or more and those in whom the margin distance was less than 8 mm, (23% and 22%, respectively). The median follow-up was 31 months (range, 2-90 months). <h3>Conclusions:</h3> Several studies showed that pathological margin distance of more than 8 mm is an important predictor for local recurrence. This finding was not confirmed in the present study.