A 61-year-old lady, with history of aortic and mitral valve regurgitation developed infective endocarditis due to acinetobacter following tooth extraction. While on antibiotic treatment, she developed pain and swelling of left calf. Duplex scan was done with a suspicion of deep vein thrombosis. It showed a leaking pseudo aneurysm of the peroneal artery, which was confirmed on angiography. Surgical repair of the defect on the peroneal artery with excision of pseudo aneurysm was done. She recovered on continued antibiotic therapy. Isolated pseudo aneurysm of peroneal artery following infective endocarditis is rare and mimics calf vein thrombosis. Surgical repair may give good results.