In the new situation of increasingly fierce conflict and dialogue, collision and integration of civilization, the spirit of cultural tolerance and the wisdom of cross-cultural communication represented by Pearl Buck have become an important spiritual wealth and contain great value of The Times. This study uses big data thinking and web crawler technology to collate and verify the connotation of Pearl Buck's cultural thought and explore the rules and methods of Pearl's cross-cultural communication. According to the communication theory, this paper clarifies the influential factors of Pearl S. Buck's cultural communication from five aspects: communicator, communication content, communication channel, communication object and communication effect, and establishes Pearl S. Buck's cultural communication model. Through diversified communication subjects, analysis and arrangement of objective, authentic and valuable story content, we focus on creating the communication function of new financial media such as short videos, social software, official account, and UP owners, and subdivide the communication audience. By strengthening the construction of cultural exchange bases, we can influence ordinary domestic people, overseas Chinese communities, and key influential overseas Chinese to learn about Pearl S. Buck culture, In the later period, the communication system of Pearl S. Buck's story was constantly improved through practical tests to enhance the global influence of Pearl S. Buck's culture.