This study investigated the impact of backpressure of anode and cathode on the performance of a high-temperature proton exchange membrane fuel cell stack consisting of 30 cells, initially operating at a current density of 0.4 A/cm², temperature of 160 ℃, and 0 bar with pure H2. Subsequently, the backpressure on both sides was varied from 0 bar to 1.5 bar, and the changes in stack performance were recorded throughout the testing period. Additionally, the impact of backpressure was also investigated with reformates (H2/CO2/CO/N2 = 69.4%/22.3%/1.40%/6.9%) as anode feed for the stack. The results showed that increase in operating backpressure improves the fuel cell performance. A stack voltage increase of 20 mV per cell and 40 mV per cell were achieved for the pure hydrogen operation and reformate gas operation respectively when increasing backpressure from 0 bar to 0.5 bar. This signifies potential to improve the system’s overall efficiency with only minor penalty in terms of auxiliary power loss to increase the back pressure.